Prediction and Characterization of Acute and Chronic Postoperative Pain
CompletedNCT01308385
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Despite enormous progress insufficient postoperative pain management remains a frequent problem in the early postoperative phase after surgery. Furthermore, the pain that persists after healing of the surgical wound is a large, but often unrecognized, clinical problem and it is estimated that 5-10% of those undergoing surgery will develop severe persistent pain leading to chronic disability and psychosocial distress. Conditioned Pain Modulation (CPM), also known as the phenomenon "pain-inhibits-pain", is a reduction in pain somewhere on the body in response to the application of a second painful stimulus outside the painful area. In recent years, the CPM has been identified as a psycho-physical measure with clinical relevance in characterizing the individual's ability to modulate pain and consequently the individual's disposition to acquire painful conditions. The purpose of this study is primarily to assess the relationship between CPM efficacy and clinical postoperative pain (postoperative pain intensity, use of analgesics, the intensity of secondary hyperalgesia and allodynia, and the incidence of persistent postoperative pain) associated with minimally invasive repair of pectus excavatum. In addition, the study aims at identifying other patient- and/or surgery-related factors affecting the course of postoperative pain. Hypothesis: \- The greater the positive difference between the experimental pressure pain threshold (kPa) measured before and after application of a second painful stimulus (Cold Pressor Test), the lower the risk of developing persistent postoperative pain. Secondary hypotheses * The greater the positive difference between the experimental pressure pain threshold (kPa) measured before and after application of a different experimental painful stimulus (Cold Pressor Test) lower the pain intensity in the early postoperative period. * The greater the positive difference between the experimental pressure pain threshold (kPa) measured before and after a…
Study details
- Official title
- Prediction and Characterization of Acute and Chronic Postoperative Pain - a Longitudinal Observational Study of the Relationship Between Experimental Pain Modulation and Clinical Postoperative Pain in Patients Undergoing Minimally Invasive Repair of Pectus Excavatum
- Conditions
- Pain
- Pain, Postoperative
- Funnel Chest
- Interventions
- Other: Conditioned pain modulation
- Sponsor
- University of Aarhus
- Start date
- 2011-04
- Primary completion
- 2012-10
- Sex
- All
- Age range
- from 15 Years
- Results posted
- No results posted in this snapshot
- Countries
- Denmark
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Patients undergoing minimally invasive repair of pectus excavatum * Age \> 15 years old Exclusion Criteria: * Previous thoracic surgery interventions * Disorders affecting the central or peripheral nervous system * Chronic pain (pain intensity assessed by numerical rating scale \> 3) * Inability to speak and understand Danish (instructions, questionnaires) * Inability to understand and participate in experimental pain modulation * Psychiatric disorders (ICD-10) * A history of frostbite in the non-dominant upper limb * Sores or cuts on non-dominant upper limb * Cardiovascular disease * A history of fainting and/or seizures * Fracture in non-dominant upper limb * Reynaud's phenomenon
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT01308385