Epigenetics and Psychoneurologic Symptoms in Women With Breast Cancer
CompletedNCT01411943
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
This study examines the relationship among epigenetic alterations and the development and persistence of psychoneurologic symptoms (cognitive dysfunction, depressive symptoms, anxiety, fatigue, sleep disturbance, and pain) in women receiving chemotherapy for early stage breast cancer. The relationship among inflammatory markers and psychoneurologic symptoms will also be explored. It is hypothesized: 1. Chemotherapy triggers inflammatory activation, which in turn leads to the acquisition of genetic alterations. These alterations result in cellular changes and are modified over time. 2. Inflammatory activation and epigenetic alterations are related to the temporal development, severity, and persistence of psychoneurologic symptoms.
Study details
- Official title
- Epigenetic Factors Associated With Symptoms and Complications of Chronic Disorders
- Conditions
- Sponsor
- Virginia Commonwealth University
- Start date
- 2011-01
- Primary completion
- 2015-03
- Sex
- Female
- Age range
- from 21 Years to 81 Years
- Results posted
- No results posted in this snapshot
- Countries
- United States
- Total sites listed
- 2
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * At least 21 years of age * Diagnosed with stage I to IIIa Breast Cancer * Scheduled to receive chemotherapy Exclusion Criteria: * previous cancer history * previous chemotherapy history * dementia * active psychosis
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT01411943