Breast Cancer: clinical trials and information

Cancer-related pain can come from a tumour pressing on bones, nerves or organs, or from cancer treatments such as surgery, chemotherapy or radiation. It can be short-term or long-lasting.

Trials with Canadian sites

Recruiting in Canada

Registry records worldwide

Breast Cancer clinical trials in Canada

7 trials, recruiting first

		Phase	Provinces
Chronic Cancer Pain Management Program NCT06101849	Completed	Not applicable	Ontario	Hamilton Health Sciences Corporation	2024-01-03
Prevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery (PLAN) NCT04874038	Active, not recruiting	Phase 3	Alberta, Newfoundland and Labrador, Nova Scotia, Ontario, Quebec	University Health Network, Toronto	2021-09-22
Intercostobrachial Nerve Sparing to Reduce Post-Surgical Pain NCT03421522	Unknown status	Not applicable	Ontario	McMaster University	2019-10-15
The Effect of an Inter-Disciplinary Program, Including MBSR, in Breast Cancer Survivors With Chronic Neuropathic Pain NCT02125006	Completed	Not applicable	Ontario	Ottawa Hospital Research Institute	2013-10
The Effect of Soy Protein on Post- Breast Cancer Surgery Pain NCT01047774	Terminated	Phase 2	Quebec	Dr. Yoram Shir	2010-03
Postoperative Analgesia Impact of Narcotic Free Anesthesia NCT01544959	Completed	Not applicable	Quebec	Université de Sherbrooke	2010-01
Reducing Pain and Disability After Breast Cancer Surgery NCT01089933	Completed	Not applicable	Ontario	Ottawa Hospital Research Institute	2009-09

Breast Cancer clinical trials worldwide (outside Canada)

53 trials, 6 recruiting or not yet recruiting. Recruiting first.

		Phase	Countries
Ultrasound Guided Pecs Block and Ketamine Infusion for Preventing Chronic Pain in Patients Undergoing Breast Cancer Surgery NCT07197684	Not yet recruiting	Not applicable		Aga Khan University	2026-03-16
Dosing Physical Activity Among Older Cancer Survivors Who Experience Chronic Pain: a Micro-randomized Trial NCT07227077	Recruiting	Not applicable	United States	Medical College of Wisconsin	2026-02-07
Impact of Cognitive Impairment on Chronic Pain in Breast Cancer NCT07877376	Recruiting		France	Nadine ATTAL	2026-01-09
Opioid-free Anaesthesia in Breast Cancer Surgery NCT06404983	Recruiting	Not applicable	Greece	University of Ioannina	2022-12-28
Long-term Outcomes of Lidocaine Infusions for Post-Operative Pain (LOLIPOP) Trial NCT05072314	Recruiting	Phase 3	Australia, Hong Kong, New Zealand, United Kingdom	Monash University	2022-07-27
A Study to Reduce Persistent Post-mastectomy Pain Using Opioid-free Anesthesia NCT05146778	Recruiting	Not applicable	South Korea	Gangnam Severance Hospital	2021-12-16
Development and Assessment of the 8-item Chronic Pain Acceptance Questionnaire to Measure Disease Acceptance in Women With Breast Cancer NCT07328321	Completed		Italy	G. d'Annunzio University	2025-01-13
The Effect of Ultrasonography-guided Fascial Plane Blocks in Breast Cancer Surgery Patients NCT06419504	Completed		Turkey (Türkiye)	Antalya Training and Research Hospital	2024-05-17
Mirtazapine for Acute and Chronic Post Mastectomy Pain NCT06499090	Completed	Early phase 1	Egypt	Assiut University	2024-03-01
Rhomboid Intercostal Plane Block on Chronic Pain Incidence and Acute Pain Scores After Mastectomy NCT06019325	Completed	Not applicable	Turkey (Türkiye)	Muğla Sıtkı Koçman University	2023-09-07
Clinical Classification of Pain in Breast Cancer Survivors NCT04219072	Completed		Turkey (Türkiye)	Kutahya Health Sciences University	2023-07-01
Investigation of the Efficiency of Pain Neuroscience Education in Patients With Chronic Pain After Breast Cancer Surgery NCT06052085	Unknown status	Not applicable	Turkey (Türkiye)	Hacettepe University	2023-02-15
Web-based Pain Coping Skills Training for Breast Cancer Survivors With AI-Associated Arthralgia NCT05703178	Active, not recruiting	Phase 3	United States	Northwestern University	2023-01-19
Pain Neuroscience Education and Therapeutic Exercise as a Treatment for Breast Cancer Survivors Living With Sequelae NCT05452499	Completed	Not applicable	Mexico	Universidad Autónoma de Yucatán	2022-09-05
Optimizing Psychological Treatment for Pain After Breast Cancer NCT05444101	Unknown status	Not applicable	Denmark	University of Aarhus	2022-09-01
Impact of Regional Anesthesia on Chronic Post-operative Pain NCT05876390	Enrolling by invitation		Italy	Niguarda Hospital	2022-09-01
Can Chronic Post-surgical Pain be Reduced by Preserving Intercostobrachial Nerve During Axillary Lymph Node Dissection? : A Randomized Controlled Trial NCT05198622	Unknown status	Not applicable	Pakistan	Shaukat Khanum Memorial Cancer Hospital & Research Centre	2022-01-30
Predicting Chronic Pain Following Breast Surgery NCT04967352	Unknown status		United States	University of California, San Diego	2021-07-19
Effect of Perioperative CBT on Chronic Persistent Postsurgical Pain Among Breast Cancer Patients NCT04924010	Completed	Not applicable	Ireland	Mater Misericordiae University Hospital	2021-05-31
Sulfasalazine in Decreasing Opioids Requirements in Breast Cancer Patients NCT03847311	Completed	Phase 2	United States	University of Arizona	2021-05-03
Optimizing Psychological Treatment for Pain After Breast Cancer: A Pilot Study NCT04841928	Completed	Not applicable	Denmark	University of Aarhus	2021-03-01
Analgesic Effect of Resistance Training for Breast Cancer Survivors NCT04509284	Completed	Not applicable	Denmark	Aalborg University	2020-08-10
The Impact of Pecs Blocks on Postmastectomy Pain Syndrome NCT04586751	Completed	Not applicable	Cyprus, Greece	Aretaieion University Hospital	2020-08-01
Preoperative Regional Nerve Block for Acute and Chronic Post-Operative Pain Following Mastectomy NCT04019834	Completed	Early phase 1	United States	University of Alabama at Birmingham	2020-07-06
Effects of Manual Therapy on Chronic Pain and Functionality of Breast Cancer Survivors NCT04084600	Terminated	Not applicable	Brazil	University of the State of Santa Catarina	2019-11-01
Exploring the Link Between Cancer Genetics and PPSP NCT04007861	Unknown status			Institute of Cancer Research, United Kingdom	2019-07
Chronic Pain and Minor Breast Cancer Surgery NCT03912948	Completed		France	Institut Claudius Regaud	2019-04-01
The Effects of Anesthetics on Persistent Pain Following Breast Cancer Surgery NCT03782896	Completed		South Korea	Samsung Medical Center	2018-12-31
Acupressure for Pain and Opioid Use Among Breast Cancer Patients NCT03655600	Terminated	Not applicable	United States	University of Michigan	2018-09-17
Serratus Plane Block in Preventing Postoperative Pain of Mastectomy NCT03615430	Completed	Not applicable	China	Feng Xia	2018-08-01
The Sequelae of Mastectomy and Quadrantectomy Respect to the Reaching Movement in Breast Cancer Survivors NCT04145739	Completed	Not applicable	Italy	University of Roma La Sapienza	2018-04-23
The Recovery of Reaching Movement in Breast Cancer Survivors: Two Different Rehabilitative Protocols in Comparison NCT04166279	Completed	Not applicable	Italy	University of Roma La Sapienza	2018-01-08
Evaluation And Risk Assessment For Persistent Postsurgical Pain After Breast Surgery NCT03408717	Active, not recruiting		Singapore, United States	KK Women's and Children's Hospital	2018-01-03
Paravertebral Block and Reduction in Opioid Consumption After Mastectomy NCT07817797	Completed	Not applicable	Tunisia	University Tunis El Manar	2018-01-01
Effect of a Topical Ketamine on Acute and Chronic Pain, Dose Finding NCT03165149	Completed	Phase 2, Phase 3	Egypt	Assiut University	2017-06-01
Evaluation of Persistent Postsurgical Pain After Breast Surgery With a Pectoral Nerves Block (Pecs) Type II NCT03116048	Completed	Not applicable	Belgium	GZA Ziekenhuizen Campus Sint-Augustinus	2017-05-02
Genetic, Neurophysiological and Psychological Predictive Factors of Chronic Neuropathic Pain After Surgery for Breast Cancer NCT02944721	Withdrawn	Not applicable	France	Hopital Foch	2016-11
Enhancing Management of Chronic Pain and Symptoms Among Women Treated for Breast Cancer (Lymph-Flow) NCT02462226	Completed	Not applicable	United States	NYU Langone Health	2015-05-01
Persistent Post-Surgical Pain in Women With BrCA NCT02266082	Completed		United States	University of Florida	2015-05
Pillars4Life Trial NCT02465892	Completed	Not applicable	United States	Duke University	2015-05
Effect of Chemotherapy on Pain Sensitivity and Patient-reported Symptoms NCT01983982	Completed		United States	University of Michigan	2013-11
The Effectiveness of Mindfulness on Chronic Pain in Breast Cancer Survivors NCT01674881	Completed	Not applicable	Denmark	University of Aarhus	2012-09
Pilot Functional Imaging Study to Evaluate Mechanisms Underlying Chronic Pain in Breast Cancer Patients NCT01639417	Completed		United States	Lynn Henry	2012-05
Prediction of Pain After Breast Cancer Surgery With EEG NCT01392248	Terminated		Netherlands	Maastricht University Medical Center	2011-07
Epigenetics and Psychoneurologic Symptoms in Women With Breast Cancer NCT01411943	Completed		United States	Virginia Commonwealth University	2011-01
Cancer in Patients With Gabapentin (GPRD) NCT01236053	Completed			GlaxoSmithKline	2010-06
Chronic Post Breast Surgery Pain NCT00847067	Terminated	Not applicable	United States	Mayo Clinic	2009-02
Nurse-Provided Care or Standard Care in Treating Patients With Stage I, Stage II, or Stage III Breast Cancer NCT00903305	Withdrawn	Not applicable		City of Hope Medical Center	2008-07
Persistent Pain After Reconstruction Following Mastectomy NCT01738048	Completed		Denmark	Copenhagen University Hospital, Rigshospitalet	2008-01
Chronic Pain in Women Who Have Undergone Surgery for Stage I, Stage II, or Stage III Breast Cancer NCT00971919	Unknown status		United Kingdom	Aberdeen Royal Infirmary	2007-03

About Breast Cancer

What is Breast Cancer?

Cancer-related pain can come from a tumour pressing on bones, nerves or organs, or from cancer treatments such as surgery, chemotherapy or radiation. It can be short-term or long-lasting.

How is Breast Cancer usually assessed?

Cancer care teams usually assess pain regularly using rating scales and questions about where it is, how it feels and how it affects daily life.

What kinds of treatments are studied for Breast Cancer?

Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.

How can I find Breast Cancer clinical trials in Canada?

This page lists 7 registry records for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.

Sources

Related conditions

Related interventions

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.