Preventing Pain After Heart Surgery
CompletedPhase 4NCT01480765
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The use of pre-emptive analgesia to prevent pain following sternotomy for cardiac surgery
Study details
- Official title
- Prospective, Double-blinded, Randomised, Placebo Controlled Trial of Pre-emptive Analgesia to Prevent Pain Following Sternotomy for Cardiac Surgery.
- Conditions
- Pain
- Hyperalgesia
- Chronic Illness
- Neuropathic Pain
- Interventions
- Drug: Pregabalin
- Drug: Ketamine infusion
- Drug: Placebo capsules
- Drug: Placebo infusion
- Sponsor
- Barts & The London NHS Trust
- Start date
- 2011-12-12
- Primary completion
- 2013-03-07
- Sex
- All
- Age range
- from 18 Years to 80 Years
- Results posted
- No results posted in this snapshot
- Countries
- United Kingdom
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Informed Consent * First time sternotomy for all cardiac surgery * Patient aged 18 - 80 years Exclusion Criteria: * Emergency surgery (decision to operate taken on the day of surgery) * Previous sternotomy * Preoperative renal failure (eGFR \<60 ml/min) * History of chronic non-anginal pain * Chronic pain medication other than paracetamol and non-steroidal anti-inflammatory drugs * Concurrent use of oxycodone, lorazepam, or ethanol. * Concurrent use of any drugs for neuropathic pain e.g. antiepileptics, antidepressants * Allergy to pregabalin, gabapentin or ketamine * Pregnancy * Limited understanding of numerical scoring scales * Previous participation in other trials investigating analgesic agents or any IMP in previous three months
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT01480765