Phase II Study of STA-2 in Patients With Chronic Stable Angina

Inclusion criteria: 1. Male or female aged \> 20; 2. Patients who had effort-induced angina which was relieved by rest or nitroglycerin, or who had catheterization-documented coronary artery disease or previous myocardial infarction ≥ 3 months before screening; 3. Patients who manifested positive ETT (exercise tolerance testing) (defined as ST-segment depression ≥ 1 mm compared with at rest, with or without limiting angina) at screening (Day -7); 4. Patients who manifested positive ETT (exercise tolerance testing) (defined as ST-segment depression ≥ 1 mm compared with at rest, with or without limiting angina) on the day of enrollment (Day 0). ETT performance between Day -7 and Day 0 were required not differ by \>20% in total exercise time; 5. Female patient who was in the post-menopausal stage or of childbearing potential who: * used adequate contraception since last menstruation and no plan for conception during the study; * was non-lactating; * had negative pregnancy test (urine) within 14 days prior to the study; 6. Able to provide written informed consent. Exclusion criteria: 1. Patients with pre-excitation, conduction abnormalities, pacemaker rhythm, unstable angina or myocardial infarction within the preceding 3 months; 2. Patients with heart failure (New York Heart Association class III or IV), uncorrected valvular or congenital heart disease, patients who needed digoxin, isosorbide mononitrate, nitroglycerin sustained release preparation, theophylline, class I antiarrhythmic agents, digitalis, or monoamine oxidase inhibitors, as judged by the investigator; 3. Patients with any EKG abnormalities preventing the interpretation of ischemia (complete left bundle branch block); 4. Patients with Chronic Obstructive Pulmonary Disease (COPD) requiring bronchodilators; 5. Patients with hepatic failure (defined as aspartate transaminase (AST) and/or alanine transaminase (ALT) \> 3X the upper limit of normal values), and/or renal failure (defined as serum creatinine \> 3 mg/dL); 6. Patients with severe gastrointestinal illness as judged by the investigator; 7. Patient with any conditions that interfered the performance of exercise tolerance test as judged by investigator (e.g., knee/ankle arthropathy, Parkinsonism, stroke).