MR(Magnetic Resonance) Imaging of Neurotransmitters in Chronic Pain
TerminatedNot applicableNCT01620775
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
This study is designed to assess: Hypothesis #1: That there is a significant central pain component in a distinct subset of patients diagnosed with knee osteoarthritis(KOA), Chronic low back pain(CLBP), painful diabetic neuropathy(PDN.) Hypothesis # 2: To establish a reliable strategy for differentiation of central pain predominant from peripheral pain predominant knee osteoarthritis(KOA), chronic low back pain(CLBP)and peripheral diabetic neuropathy(PDN) patients using clinical features, experimental pain testing and magnetic resonance(MR) Spectroscopy.
Study details
- Official title
- MR (Magnetic Resonance) Imaging of the Excitatory and Inhibitory Neurotransmitters in Chronic Pain
- Conditions
- Chronic Low Back Pain
- Diabetic Peripheral Neuropathy
- Knee Osteoarthritis
- Interventions
- Other: MRIs
- Other: Pain testing
- Sponsor
- University of Michigan
- Start date
- 2012-09
- Primary completion
- 2017-06-07
- Sex
- All
- Age range
- from 30 Years to 70 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- United States
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: \- Must be Right Handed. (Chronic Pain with knee osteoarthritis) * Diagnosed with: unilateral, symptomatic knee osteoarthritis based on American College of Rheumatology (ACR) criteria. * Have had a knee x-ray within the last 6 months. * Must have average pain intensity of 4 or greater on a 0 (no pain) to 10 (worst pain imaginable) scale. (Chronic Low Back Pain) * Have primary complaint of constant or intermittent back pain of at least 6 months duration. * Have a Roland Morris Disability Questionnaire score of \>7. (Diabetes Mellitus with Painful Peripheral Neuropathy) * Have a diagnosis of diabetes mellitus for at least 6 months. * Have a diagnosis of diabetic peripheral neuropathy. * Have had Electromyography(EMG) testing within the last 6 months. * Have a \>40 mm score on the short-form McGill Pain questionnaire. (Healthy controls) * Must be pain free * No history of neurological or psychiatric illness. * No diagnosis of Diabetes Mellitus. * No evidence of neuropathy on clinical assessment. Exclusion Criteria: * Being pregnant. * Have metal in the body or other contraindications to Magnetic Resonance Imaging (MRI). * Have a chronic pain condition unrelated to knee osteoarthritis, chronic low back pain or diabetes. * Have currently or a history of brain infection, stroke or tumor. * Have a risk factor for other non-diabetic neuropathies
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT01620775