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Knee Osteoarthritis: clinical trials and information

Osteoarthritis is the most common form of arthritis. It involves breakdown of cartilage and changes in the bone and tissues of a joint, most often in the knees, hips, hands and spine, and can cause pain, stiffness and reduced movement.
5
Trials with Canadian sites
0
Recruiting in Canada
102
Registry records worldwide

Knee Osteoarthritis clinical trials in Canada

5 trials, recruiting first
PhaseProvinces
Brain MRI for Knee OA
NCT05986513
Unknown statusNot applicableOntarioToronto Rehabilitation Institute2023-09-01
Intra-Operative Adductor Canal Blocks
NCT05601427
CompletedNot applicableOntarioOttawa Hospital Research Institute2023-03-22
Opioid Reduction in Orthopaedic Surgery (OREOS) - Knees
NCT04968132
CompletedNot applicableOntarioKim Madden2022-03-09
Neurophysiological Mechanisms Involved in Knee Osteoarthritis
NCT03556423
CompletedQuebecUniversité de Sherbrooke2018-07-01
Subchondroplasty® Knee RCT
NCT03112200
CompletedNot applicableOntarioZimmer Biomet2017-03-29

Knee Osteoarthritis clinical trials worldwide (outside Canada)

97 trials, 19 recruiting or not yet recruiting. Recruiting first.

PhaseCountries
IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success
NCT07494838
Not yet recruitingNot applicableUnited StatesLucas R. Cusumano, MD2026-12-30
Effects of Music During Walking on Pain and Muscle Activation in People With Chronic Pain Due to Knee Osteoarthritis
NCT07537114
Not yet recruitingNot applicableBoston University Charles River Campus2026-11
Validating Blinding Maintenance of a Sham-Sensitization Control Design for Sensitization Acupuncture Trials
NCT07868224
Not yet recruitingNot applicableChinaJiangxi University of Traditional Chinese Medicine2026-10-10
Effect of Inspiratory Muscle Training on Knee Osteoarthritis Pain
NCT07698418
Not yet recruitingNot applicableThe Hong Kong Polytechnic University2026-09-01
The Effect of Lipedema on Knee Osteoarthritis
NCT07575555
RecruitingTurkey (Türkiye)Izmir Democracy University2026-07-07
Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain
NCT07639060
RecruitingUnited StatesYale University2026-06-20
Nerve to Vastus Medialis Branches in Chronic Knee Pain
NCT07703293
RecruitingTurkey (Türkiye)Diskapi Teaching and Research Hospital2026-05-20
Sonographic Thigh Adjustment Ratio and Subcutaneous Fat Thickness as Predictors of Genicular Nerve Block Response in Knee Osteoarthritis
NCT07712419
RecruitingTurkey (Türkiye)Gaziosmanpasa Research and Education Hospital2026-05-15
Efficacy and Safety of Endovenous Ablation for Relief of Knee Pain in Elderly Patients With Lower Extremity Varicose Veins: A Prospective Observational Study
NCT07239284
Not yet recruitingChengdu University of Traditional Chinese Medicine2025-12-10
Perineural Prolotherapy in Chronic Knee Osteoarthritis Pain.
NCT07245121
RecruitingNot applicableGreeceNational and Kapodistrian University of Athens2025-11-24
Knee Pain Relief After Endovenous Treatment for Lower Limb Varicose Veins: A Prospective Observational Study
NCT07163312
Not yet recruitingChengdu University of Traditional Chinese Medicine2025-10-01
"Bimodal vs Unimodal High-Intensity Pulsed Electromagnetic Field Therapy in Older Adults With Knee Osteoarthritis"
NCT07198750
RecruitingNot applicableMexicoHospital Civil de Guadalajara2025-09-15
BioPoly® Partial Resurfacing Knee Implant IDE
NCT06915363
RecruitingNot applicableUnited StatesBioPoly LLC2025-03-17
Pulsed Radiofrequency Therapy vs Canal Adductor Blockade in Knee Osteoarthritis
NCT05962463
RecruitingSloveniaUniversity Medical Centre Ljubljana2024-10-09
Upper and Lower Extremity Exercise and Exercise-Induced Hypoalgesia in Knee Osteoarthritis
NCT06105788
RecruitingNot applicableUnited StatesUniversity of Texas, El Paso2023-11-15
The Effect of RF Genicular Nerve Block Applied in the Preoperative Period on Fast-track Total Knee Arthroplasty
NCT06239649
RecruitingTurkey (Türkiye)Pamukkale University2023-10-19
Diet Interventions: Remitted and Evaluated as Complementary Treatments for Pain
NCT05785884
RecruitingNot applicableUnited StatesUniversity of Alabama at Birmingham2023-02-01
Focused Extracorporeal Shockwave Therapy for Knee Arthritis
NCT05596591
RecruitingNot applicableUnited StatesKessler Foundation2022-10-13
Prospective Functional, Gait, and Outcome Comparison Study of Medial Pivot Versus Single Radius Design for Total Knee Arthroplasty
NCT04814082
RecruitingNot applicableUnited StatesLifeBridge Health2021-02-01
Effectiveness of Exercise Plus Pain Neuroscience Education on Brain Function in Knee Osteoarthritis
NCT06482970
Unknown statusNot applicableUniversidad Santo Tomas, Chile2025-03-15
Prevalence and Characteristics of Widespread Pain in People With Knee Osteoarthritis
NCT06854237
Active, not recruitingSwedenVastra Gotaland Region2025-02-06
Genicular Artery Embolization (GAE) for Osteoarthritic Knee Pain
NCT04472091
WithdrawnNot applicableUnited StatesAndrew Picel2025-01-15
Two-level ESPB in Total Knee Arthroplasty
NCT06470542
CompletedPhase 4PolandPoznan University of Medical Sciences2024-11-07
Dexamethasone vs. Dexmedetomidine for ESPB in Pain Management After Knee Arthroplasty
NCT06470100
CompletedPhase 4PolandPoznan University of Medical Sciences2024-08-13
Dexamethasone for iPACK Block With ACB in Total Knee Arthroplasty
NCT06470204
CompletedPhase 4PolandPoznan University of Medical Sciences2024-08-13
ESPB vs iPACK+ACB in Total Knee Arthroplasty
NCT06302218
Unknown statusPhase 4PolandPoznan University of Medical Sciences2024-04-01
Erector Spinae Plane Block Vs. IPACK Block with Adductor Canal Block for Total Knee Arthroplasty
NCT06233630
CompletedPhase 4PolandPoznan University of Medical Sciences2024-03-30
NLR and PLR Levels Following IPACK Block in Knee Arthroplasty
NCT06304298
CompletedPhase 4PolandPoznan University of Medical Sciences2024-03-30
Physical Therapy vs Remote Exercise for Knee Pain Due to Osteoarthritis (OA)
NCT06167304
TerminatedNot applicableUnited StatesIcahn School of Medicine at Mount Sinai2024-01-29
Ultrasound-Guided Adductor Canal Block for Total Knee Arthroplasty Surgery
NCT06084403
CompletedNot applicableTurkey (Türkiye)Bursa City Hospital2023-12-20
Genicular Artery Embolization Vs Observation for Symptomatic Knee Osteoarthritis
NCT04682652
Active, not recruitingNot applicableUnited StatesUniversity of California, Los Angeles2023-08-01
Transcutaneous Pulsed Radiofrequency Application Plus Genicular Nerve Block Versus Intraarticular Hyaluronic Acid Injection for Management of Chronic Pain in Knee Osteoarthritis.
NCT06710782
CompletedNot applicableEgyptTanta University2023-08-01
Maximizing Patient Goal Attainment
NCT05652270
Active, not recruitingNot applicableUnited StatesDartmouth-Hitchcock Medical Center2023-05-30
Pain Management In Knee Osteoarthritis
NCT05844319
Unknown statusNot applicableTurkey (Türkiye)Istanbul University2023-05-01
P4ACE Trial for Persons With Chronic Knee Pain
NCT05623683
CompletedNot applicableDenmarkNorthwestern University2023-04-20
Prevention, Management and Rehabilitation of Knee Osteoarthritis at the Workplace
NCT05822401
Unknown statusNot applicableNational Research Centre for the Working Environment, Denmark2023-04-11
Evaluation of the Effect of a Food Supplement Based on Hydrolyzed Collagen on Joint Function.
NCT05917925
Unknown statusNot applicableSpainFrancisco Javier Martínez Noguera2023-04-01
Central Sensitization in Total Knee Arthroplasty Patients with Persistent Pain
NCT05575310
CompletedSpainUniversity of Barcelona2023-01-01
Clinial Application of Park et al.(The Knee 27 (2020) 1577-1584)'s Study
NCT05202847
WithdrawnNot applicableGangnam Severance Hospital2022-12-07
The Relationship of the Medial Longitudinal Arch Height With Clinical Features of Knee Osteoarthritis
NCT05656014
CompletedTurkey (Türkiye)Gazi University2022-12-07
Arthritis Ease Study
NCT05721352
CompletedPhase 1, Phase 2United StatesArizona State University2022-09-15
Evaluation of the Effect of the AI500™ SINGLE-DOSE GEL Medical Device in Patients With Reduced Knee Function
NCT05886608
CompletedNot applicableItalyContrad Swiss SA2022-08-30
Comparison of Conventional and Cooled Radiofrequency of the Genicular Nerves in Patients With Chronic Knee Pain
NCT05407610
Unknown statusNot applicableBelgium, NetherlandsZiekenhuis Oost-Limburg2022-07-07
Can Simplified and More Detailed Instructions Affect Post-Operative Narcotic Consumption
NCT03534102
WithdrawnPhase 4United StatesBrigham and Women's Hospital2022-06-06
Selective Nerve Ablation for Chronic Knee Pain: A Retrospective Study
NCT07835672
CompletedPolandMichał Bartoszewicz2022-06-01
A Study of the Feasibility of Using the Dietary Supplement "ARTNEO" in Patients With Osteoathritis
NCT05975879
CompletedNot applicableRussiaNPO Petrovax2022-05-31
The Effect of PEMF for Patients With Knee OA
NCT05548712
Unknown statusNot applicableHong KongChinese University of Hong Kong2022-05-05
The Effect of Physical Therapy Modalities and Kinesio Taping in Patients With Knee Osteoarthritis
NCT05211544
Unknown statusNot applicableTurkey (Türkiye)Abant Izzet Baysal University2022-01-21
Dorsal Root Ganglion Stimulation for the Treatment of Arthritic Knee Pain
NCT05103527
Active, not recruitingNot applicableUnited StatesKenneth B Chapman2022-01-01
Lyophilized and Micronized Particulate Human Amniotic and Umbilical Cord (TTAX03) for KL Grade 3-4 Knee OA
NCT05079035
CompletedPhase 2United StatesBioTissue Holdings, Inc2021-12-06

About Knee Osteoarthritis

What is Knee Osteoarthritis?

Osteoarthritis is the most common form of arthritis. It involves breakdown of cartilage and changes in the bone and tissues of a joint, most often in the knees, hips, hands and spine, and can cause pain, stiffness and reduced movement.

How is Knee Osteoarthritis usually assessed?

Clinicians usually assess osteoarthritis through a history, physical examination of the joint and, in some cases, X-rays. Blood tests may help rule out other types of arthritis.

What kinds of treatments are studied for Knee Osteoarthritis?

Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.

How can I find Knee Osteoarthritis clinical trials in Canada?

This page lists 5 registry records for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.

Related conditions

Related interventions

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.