Effects of Ranolazine and Exercise on Daily Physical Activity Trial
CompletedPhase 4NCT01948310
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The primary objective is to assess whether the increased angina threshold on ranolazine and subsequent higher training intensity will result in improved exercise tolerance and oxygen consumption; and greater than that observed with exercise training on placebo. The study team anticipates the chronic exercise improvements with ranolazine will be incrementally higher than the acute effects provided by ranolazine alone and demonstrated in previous trials. Key secondary objectives include the acute ranolazine and chronic exercise plus ranolazine effects on total daily energy expenditure (TDEE) and angina-related quality of life.
Study details
- Official title
- Effects of Ranolazine and Exercise on Daily Physical Activity Trial
- Conditions
- Sponsor
- Duke University
- Collaborators
- Gilead Sciences
- Start date
- 2013-12
- Primary completion
- 2016-10-10
- Sex
- All
- Results posted
- Yes, on ClinicalTrials.gov
- Countries
- United States
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Documented CAD diagnosis * Stable angina ≥ 3 months Exclusion Criteria: * Class III or IV heart failure * Myocardial Infarction or coronary revascularization procedure within 2 months * QT interval \> 500ms or prescribed medication known to prolong the QTc interval * Contraindicated Medications * Metformin dose \> 1700mg/day * Class Ia, Ic and III anti-arrhythmics * CYP3A inhibitors * Simvastatin \>20mg/day * Severe renal disease (\< 30ml/min creatinine clearance) * Currently on dialysis * Lack of transportation to the exercise and testing facilities * Implanted pacemaker that is not rate responsive
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT01948310