Molecular and Functional PET-fMRI Measures of Analgesia in Migraine

Inclusion Criteria: * Migraine patients with aura with acute episodic migraine meeting the IHS Classification ICHD-II criteria, 3-14 migraines per month. * History of episodic migraine for at least 3 years * Ages 21-50 * Male or Female * Right Handed Matched healthy subjects will also be recruited. Exclusion Criteria: * Other significant disease (systemic or CNS) * Pregnancy * Claustrophobia * Weight \>235 lbs (limit of MRI table) * Significant drug including alcohol history (\> 7 glasses of alcohol per week) * Beck Depression Inventory II (BDI-II) score \> 25 (moderate to severe depression) * Any metal implants incompatible with MRI (including dental bridges, crowns, retainers, orthodontic devices e.g. braces, IUDs, aneurysm clips or other devices, tattoos containing metallic ink, cardiac pacemakers, prosthetic hear valves, other prostheses, neurostimulator devices, implanted infusion pumps, exposure to shrapnel or metal filings, cochlear implants, etc.) * Previous significant research related exposure to ionizing radiation. * History of allergy or adverse reaction to opioids * Significant medical history of such as seizure disorder, diabetes, alcoholism, cardiac disease including coronary artery disease, psychiatric problems; drug addiction, respiratory problems, liver disease, etc. * Positive drug of abuse screen (excluding medications currently prescribed for their clinical condition, e.g. opioids, benzodiazepines, etc.) * Patients with migraine \<72 hours prior to the experiments will not be included to ensure inter-ictal state. * Opioids or preventative medication such as topiramate, SSRIs etc.