Migraine: clinical trials and information
Migraine clinical trials in Canada
| Phase | Provinces | ||||
|---|---|---|---|---|---|
| Evaluation of a Mind-Body Based Approach for Chronic Pain Treatment NCT07143396 | Not yet recruiting | Not applicable | British Columbia | University of the Fraser Valley | 2025-10 |
| Pilot Study for a Machine Learning Test for Migraine NCT05517200 | Unknown status | Ontario | Headache Sciences Incorporated | 2022-09-03 | |
| Evaluation of a Mind-body Based Application for the Treatment of Chronic/Persistent Pain. NCT05090683 | Completed | Not applicable | British Columbia | University of the Fraser Valley | 2021-10-15 |
| Efficacy and Safety of Erenumab in Pediatric Subjects With Chronic Migraine NCT03832998 | Completed | Phase 3 | Alberta, Ontario | Amgen | 2019-09-05 |
Migraine clinical trials worldwide (outside Canada)
62 trials, 13 recruiting or not yet recruiting. Recruiting first.
| Phase | Countries | ||||
|---|---|---|---|---|---|
| Sequential, Multiple Assignment, Double Randomized Preference, Migraine Behavioral Trial NCT06170281 | Not yet recruiting | Not applicable | United States | Mayo Clinic | 2026-12 |
| EMBRACE-OBS: Single-Site Observational Registry of Patient-Reported Outcomes Following MMA Embolization for Migraine NCT07652034 | Recruiting | United States | Cortex Neurovascular | 2026-09-01 | |
| Migraine is Associated With Altered Mechanical Pain Sensitivity. This Study Investigates Mechanical Pain Sensitivity, Headache Burden, and Quality of Life in Episodic and Chronic Migraine, Comparing Pressure Algometry and Algopeg® and Assessing Mechanosensitivity of Peripheral Nerves. NCT07559565 | Not yet recruiting | Austria | Bernhard Taxer | 2026-06-01 | |
| Dietary Intervention for Migraine Relief NCT07360405 | Not yet recruiting | Not applicable | United States | American University | 2026-01 |
| Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of Knee Osteoarthritis(OA) NCT07347028 | Recruiting | Not applicable | China | Beijing Tiantan Hospital | 2025-10-01 |
| New Methods for Evaluating Preventive Migraine Treatment NCT07071506 | Recruiting | Not applicable | Denmark | University of Aarhus | 2025-06-19 |
| Bilateral Middle Meningeal Artery Lidocaine Infusion for Chronic Debilitating Migraines NCT07061847 | Recruiting | Phase 2 | United States | Northwell Health | 2025-03-10 |
| Real-world Prospective Study on the Use of Anti-CGRP Drugs in Migraine NCT07159750 | Recruiting | Argentina, Chile, Colombia, Croatia and 9 more | Hospital Universitari Vall d'Hebron Research Institute | 2024-01-02 | |
| Responding With Evidence and Access for Childhood Headaches NCT05889624 | Recruiting | Not applicable | United States | Children's Hospital Medical Center, Cincinnati | 2023-08-22 |
| Gepant treAtments: EffectIveNess and tolERability (GAINER) NCT05903027 | Recruiting | Italy | University of Florence | 2023-06-15 | |
| Overlapping Pain Trajectory Study NCT05752396 | Recruiting | United States | Children's Hospital Medical Center, Cincinnati | 2023-03-01 | |
| Molecular Phenotyping of Migraine Patients According to Sex and Age Through CGRP Quantification NCT06674772 | Recruiting | Spain | Hospital Universitari Vall d'Hebron Research Institute | 2022-11-29 | |
| Determining the Utility of a Behavioral Intervention in Chronic Migraine NCT05415020 | Recruiting | Not applicable | United States | Mayo Clinic | 2022-06-29 |
| Vibratory Stimulation for the Treatment of Chronic Pain NCT04069572 | Suspended | Not applicable | United States | Stanford University | 2026-09 |
| Pericranial and General Sensitivity in Patients With Primary Headache NCT07514208 | Enrolling by invitation | Spain | Universitat Internacional de Catalunya | 2026-03-31 | |
| App-based Breathing Program for Migraine Relief NCT07297901 | Enrolling by invitation | Not applicable | United States | Arizona State University | 2025-12-15 |
| Evaluation of a Wearable Device for Acute Treatment of Migraines NCT07015125 | Completed | Not applicable | United States | Hinge Health, Inc | 2025-06-09 |
| Head Awareness in Chronic Migraine Patients NCT06857383 | Completed | Cyprus, Turkey (Türkiye) | Bozok University | 2025-01-02 | |
| Mindfulness-Based Intervention for Adolescents With Chronic Migraine NCT06414109 | Completed | Not applicable | United States | University of Colorado, Denver | 2024-06-04 |
| Long-term Atogepant in Real-world Practice NCT07699549 | Completed | Spain | Fundación de Investigación Biomédica - Hospital Universitario de La Princesa | 2024-06-01 | |
| Italian Real-life obServational Study on the effecTiveness, sAfety and Tolerability of Atogepant in Migraine Patients NCT06414044 | Active, not recruiting | Italy | University of Florence | 2024-05-09 | |
| A Dose-finding Trial With Lu-AG09222 in Adults With Migraine Who Have Not Been Helped by Prior Preventive Treatments NCT06323928 | Completed | Phase 2 | Bulgaria, Czechia, Denmark, France and 10 more | H. Lundbeck A/S | 2024-04-01 |
| Effectiveness and Tolerability of Eptinezumab NCT06409845 | Completed | Italy | University of Florence | 2024-03-26 | |
| Impementation of the Exercise Recommendations for the Treatment of Primary Headaches: A Qualitative Approach to the Headache Units in Catalonia NCT06127888 | Unknown status | Spain | Fundació Universitària del Bages | 2024-03-20 | |
| Vagal Nerve Stimulation and Pain Frequency, Intensity in Chronic Migraine NCT06191016 | Unknown status | Not applicable | Pakistan | Riphah International University | 2023-12-26 |
| The Living With a Long-Term Condition Study NCT06072287 | Unknown status | United Kingdom | King's College London | 2023-06-28 | |
| Ditan Acute tReatments: Effectiveness and Tolerability (DART) NCT05903040 | Completed | Italy | University of Florence | 2023-06-15 | |
| The Effect of Different Exercise Types on Migraine Frequency in Individuals With Migraine NCT05568004 | Completed | Not applicable | Turkey (Türkiye) | Ege University | 2022-11-28 |
| Effectiveness of Multimodal Physical Therapy in Migraine NCT05226559 | Unknown status | Not applicable | Italy | Neuromed IRCCS | 2022-02-24 |
| Quest to Analyze One Thousand Humans Meditating NCT06583395 | Enrolling by invitation | United States | Tobias Moeller-Bertram | 2021-12-05 | |
| Presence of Signs of Central Sensitization in Episodic and Chronic Migraine NCT05162664 | Completed | Not applicable | Belgium | University Ghent | 2021-10-15 |
| Prevalence of Chronic Abdominal Pain in Migraneurs NCT05086562 | Unknown status | Germany | Charite University, Berlin, Germany | 2021-09-01 | |
| Chronic Pain and Conditioned Pain Modulation After on Line-behavioral Approach NCT04859374 | Unknown status | Not applicable | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | 2021-09 | |
| Pain Control in Episodic and Chronic Migraine NCT06599905 | Completed | Not applicable | Italy | IRCCS National Neurological Institute "C. Mondino" Foundation | 2021-06-15 |
| Enfacement Illusion and Chronic Migraine Pain NCT04904458 | Unknown status | Not applicable | Italy | IRCCS National Neurological Institute "C. Mondino" Foundation | 2021-04-30 |
| Mind Body Balance for Pediatric Migraine NCT04715685 | Active, not recruiting | Not applicable | United States | Children's Hospital Medical Center, Cincinnati | 2021-03-09 |
| EMG Biofeedback Treatment for Chronic Low Back Pain, Cancer Pain and Migraines NCT04607460 | Completed | Not applicable | United States | Brigham and Women's Hospital | 2020-12-03 |
| miR-155 Expression in Episodic and Chronic Migraine NCT05891808 | Unknown status | Italy | IRCCS National Neurological Institute "C. Mondino" Foundation | 2020-09-22 | |
| Study of Quality of Life in Subjects With Chronic or High-frequency Episodic Migraine and Associated Comorbidities Treated With Erenumab NCT04114630 | Withdrawn | Phase 3 | Spain | Novartis Pharmaceuticals | 2019-10-30 |
| Assessment of Prolonged Safety and tOLerability of in Migraine Patients in a Long-term OpeN-label Study NCT04084314 | Completed | Phase 4 | Germany | Novartis Pharmaceuticals | 2019-09-30 |
| Study of Efficacy and Safety of Erenumab in Adult Chronic Migraine Patients NCT03867201 | Completed | Phase 3 | China, India, Malaysia, Philippines and 5 more | Novartis Pharmaceuticals | 2019-08-26 |
| Head-to-head Study of Erenumab Against Topiramate in Patients With Episodic and Chronic Migraine NCT03828539 | Completed | Phase 4 | Germany | Novartis Pharmaceuticals | 2019-02-22 |
| Predictive Role of MIDAS Reduction at 3 Months for Erenumab Treatment NCT05442008 | Completed | Italy | IRCCS National Neurological Institute "C. Mondino" Foundation | 2018-12-01 | |
| A Study Investigating the Efficacy of GON Blocks. NCT04017741 | Completed | Phase 4 | United Kingdom | Barts & The London NHS Trust | 2018-02-14 |
| (Botox) Mechanisms of Action in Altering the Molecular Environment in Which Pain Fibers Exist NCT03381261 | Completed | Phase 4 | United States | Massachusetts General Hospital | 2017-12-01 |
| Mindfulness and Migraine Research Study NCT02824250 | Completed | Not applicable | United States | California Pacific Medical Center Research Institute | 2017-03-09 |
| Ticagrelor Therapy for RefrACTORy Migraine Study NCT02518464 | Completed | Phase 4 | United States | Columbia University | 2015-10 |
| Molecular and Functional PET-fMRI Measures of Analgesia in Migraine NCT01970943 | Completed | Not applicable | United States | Massachusetts General Hospital | 2012-09-01 |
| Effect of Osteopathic Manipulative Treatment for Patients With Chronic Headache NCT01332864 | Completed | Phase 4 | United States | Western University of Health Sciences | 2011-03 |
| Migraine--Investigational Treatment of Migraine With Noninvasive Brain Stimulation. (tDCS- Migraine) NCT00521196 | Completed | Not applicable | United States | Beth Israel Deaconess Medical Center | 2007-07 |
About Migraine
What is Migraine?
Migraine is a neurological condition with recurring headaches that are often throbbing and may come with nausea and sensitivity to light or sound. Chronic migraine usually refers to headache on 15 or more days a month for more than three months, with migraine features on at least eight of those days.
How is Migraine usually assessed?
Diagnosis is usually based on the pattern of symptoms described in a history and a neurological examination. A headache diary is often used. Tests may be done to rule out other causes.
What kinds of treatments are studied for Migraine?
Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.
How can I find Migraine clinical trials in Canada?
This page lists 4 registry records for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.
Related conditions
Related interventions
Related US FDA drug labels
Labels whose indications text mentions this term. US labels, not Health Canada Product Monographs.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.