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Migraine: clinical trials and information

Migraine is a neurological condition with recurring headaches that are often throbbing and may come with nausea and sensitivity to light or sound. Chronic migraine usually refers to headache on 15 or more days a month for more than three months, with migraine features on at least eight of those days.
4
Trials with Canadian sites
1
Recruiting in Canada
66
Registry records worldwide

Migraine clinical trials in Canada

4 trials, recruiting first
PhaseProvinces
Evaluation of a Mind-Body Based Approach for Chronic Pain Treatment
NCT07143396
Not yet recruitingNot applicableBritish ColumbiaUniversity of the Fraser Valley2025-10
Pilot Study for a Machine Learning Test for Migraine
NCT05517200
Unknown statusOntarioHeadache Sciences Incorporated2022-09-03
Evaluation of a Mind-body Based Application for the Treatment of Chronic/Persistent Pain.
NCT05090683
CompletedNot applicableBritish ColumbiaUniversity of the Fraser Valley2021-10-15
Efficacy and Safety of Erenumab in Pediatric Subjects With Chronic Migraine
NCT03832998
CompletedPhase 3Alberta, OntarioAmgen2019-09-05

Migraine clinical trials worldwide (outside Canada)

62 trials, 13 recruiting or not yet recruiting. Recruiting first.

PhaseCountries
Sequential, Multiple Assignment, Double Randomized Preference, Migraine Behavioral Trial
NCT06170281
Not yet recruitingNot applicableUnited StatesMayo Clinic2026-12
EMBRACE-OBS: Single-Site Observational Registry of Patient-Reported Outcomes Following MMA Embolization for Migraine
NCT07652034
RecruitingUnited StatesCortex Neurovascular2026-09-01
Migraine is Associated With Altered Mechanical Pain Sensitivity. This Study Investigates Mechanical Pain Sensitivity, Headache Burden, and Quality of Life in Episodic and Chronic Migraine, Comparing Pressure Algometry and Algopeg® and Assessing Mechanosensitivity of Peripheral Nerves.
NCT07559565
Not yet recruitingAustriaBernhard Taxer2026-06-01
Dietary Intervention for Migraine Relief
NCT07360405
Not yet recruitingNot applicableUnited StatesAmerican University2026-01
Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of Knee Osteoarthritis(OA)
NCT07347028
RecruitingNot applicableChinaBeijing Tiantan Hospital2025-10-01
New Methods for Evaluating Preventive Migraine Treatment
NCT07071506
RecruitingNot applicableDenmarkUniversity of Aarhus2025-06-19
Bilateral Middle Meningeal Artery Lidocaine Infusion for Chronic Debilitating Migraines
NCT07061847
RecruitingPhase 2United StatesNorthwell Health2025-03-10
Real-world Prospective Study on the Use of Anti-CGRP Drugs in Migraine
NCT07159750
RecruitingArgentina, Chile, Colombia, Croatia and 9 moreHospital Universitari Vall d'Hebron Research Institute2024-01-02
Responding With Evidence and Access for Childhood Headaches
NCT05889624
RecruitingNot applicableUnited StatesChildren's Hospital Medical Center, Cincinnati2023-08-22
Gepant treAtments: EffectIveNess and tolERability (GAINER)
NCT05903027
RecruitingItalyUniversity of Florence2023-06-15
Overlapping Pain Trajectory Study
NCT05752396
RecruitingUnited StatesChildren's Hospital Medical Center, Cincinnati2023-03-01
Molecular Phenotyping of Migraine Patients According to Sex and Age Through CGRP Quantification
NCT06674772
RecruitingSpainHospital Universitari Vall d'Hebron Research Institute2022-11-29
Determining the Utility of a Behavioral Intervention in Chronic Migraine
NCT05415020
RecruitingNot applicableUnited StatesMayo Clinic2022-06-29
Vibratory Stimulation for the Treatment of Chronic Pain
NCT04069572
SuspendedNot applicableUnited StatesStanford University2026-09
Pericranial and General Sensitivity in Patients With Primary Headache
NCT07514208
Enrolling by invitationSpainUniversitat Internacional de Catalunya2026-03-31
App-based Breathing Program for Migraine Relief
NCT07297901
Enrolling by invitationNot applicableUnited StatesArizona State University2025-12-15
Evaluation of a Wearable Device for Acute Treatment of Migraines
NCT07015125
CompletedNot applicableUnited StatesHinge Health, Inc2025-06-09
Head Awareness in Chronic Migraine Patients
NCT06857383
CompletedCyprus, Turkey (Türkiye)Bozok University2025-01-02
Mindfulness-Based Intervention for Adolescents With Chronic Migraine
NCT06414109
CompletedNot applicableUnited StatesUniversity of Colorado, Denver2024-06-04
Long-term Atogepant in Real-world Practice
NCT07699549
CompletedSpainFundación de Investigación Biomédica - Hospital Universitario de La Princesa2024-06-01
Italian Real-life obServational Study on the effecTiveness, sAfety and Tolerability of Atogepant in Migraine Patients
NCT06414044
Active, not recruitingItalyUniversity of Florence2024-05-09
A Dose-finding Trial With Lu-AG09222 in Adults With Migraine Who Have Not Been Helped by Prior Preventive Treatments
NCT06323928
CompletedPhase 2Bulgaria, Czechia, Denmark, France and 10 moreH. Lundbeck A/S2024-04-01
Effectiveness and Tolerability of Eptinezumab
NCT06409845
CompletedItalyUniversity of Florence2024-03-26
Impementation of the Exercise Recommendations for the Treatment of Primary Headaches: A Qualitative Approach to the Headache Units in Catalonia
NCT06127888
Unknown statusSpainFundació Universitària del Bages2024-03-20
Vagal Nerve Stimulation and Pain Frequency, Intensity in Chronic Migraine
NCT06191016
Unknown statusNot applicablePakistanRiphah International University2023-12-26
The Living With a Long-Term Condition Study
NCT06072287
Unknown statusUnited KingdomKing's College London2023-06-28
Ditan Acute tReatments: Effectiveness and Tolerability (DART)
NCT05903040
CompletedItalyUniversity of Florence2023-06-15
The Effect of Different Exercise Types on Migraine Frequency in Individuals With Migraine
NCT05568004
CompletedNot applicableTurkey (Türkiye)Ege University2022-11-28
Effectiveness of Multimodal Physical Therapy in Migraine
NCT05226559
Unknown statusNot applicableItalyNeuromed IRCCS2022-02-24
Quest to Analyze One Thousand Humans Meditating
NCT06583395
Enrolling by invitationUnited StatesTobias Moeller-Bertram2021-12-05
Presence of Signs of Central Sensitization in Episodic and Chronic Migraine
NCT05162664
CompletedNot applicableBelgiumUniversity Ghent2021-10-15
Prevalence of Chronic Abdominal Pain in Migraneurs
NCT05086562
Unknown statusGermanyCharite University, Berlin, Germany2021-09-01
Chronic Pain and Conditioned Pain Modulation After on Line-behavioral Approach
NCT04859374
Unknown statusNot applicableFondazione I.R.C.C.S. Istituto Neurologico Carlo Besta2021-09
Pain Control in Episodic and Chronic Migraine
NCT06599905
CompletedNot applicableItalyIRCCS National Neurological Institute "C. Mondino" Foundation2021-06-15
Enfacement Illusion and Chronic Migraine Pain
NCT04904458
Unknown statusNot applicableItalyIRCCS National Neurological Institute "C. Mondino" Foundation2021-04-30
Mind Body Balance for Pediatric Migraine
NCT04715685
Active, not recruitingNot applicableUnited StatesChildren's Hospital Medical Center, Cincinnati2021-03-09
EMG Biofeedback Treatment for Chronic Low Back Pain, Cancer Pain and Migraines
NCT04607460
CompletedNot applicableUnited StatesBrigham and Women's Hospital2020-12-03
miR-155 Expression in Episodic and Chronic Migraine
NCT05891808
Unknown statusItalyIRCCS National Neurological Institute "C. Mondino" Foundation2020-09-22
Study of Quality of Life in Subjects With Chronic or High-frequency Episodic Migraine and Associated Comorbidities Treated With Erenumab
NCT04114630
WithdrawnPhase 3SpainNovartis Pharmaceuticals2019-10-30
Assessment of Prolonged Safety and tOLerability of in Migraine Patients in a Long-term OpeN-label Study
NCT04084314
CompletedPhase 4GermanyNovartis Pharmaceuticals2019-09-30
Study of Efficacy and Safety of Erenumab in Adult Chronic Migraine Patients
NCT03867201
CompletedPhase 3China, India, Malaysia, Philippines and 5 moreNovartis Pharmaceuticals2019-08-26
Head-to-head Study of Erenumab Against Topiramate in Patients With Episodic and Chronic Migraine
NCT03828539
CompletedPhase 4GermanyNovartis Pharmaceuticals2019-02-22
Predictive Role of MIDAS Reduction at 3 Months for Erenumab Treatment
NCT05442008
CompletedItalyIRCCS National Neurological Institute "C. Mondino" Foundation2018-12-01
A Study Investigating the Efficacy of GON Blocks.
NCT04017741
CompletedPhase 4United KingdomBarts & The London NHS Trust2018-02-14
(Botox) Mechanisms of Action in Altering the Molecular Environment in Which Pain Fibers Exist
NCT03381261
CompletedPhase 4United StatesMassachusetts General Hospital2017-12-01
Mindfulness and Migraine Research Study
NCT02824250
CompletedNot applicableUnited StatesCalifornia Pacific Medical Center Research Institute2017-03-09
Ticagrelor Therapy for RefrACTORy Migraine Study
NCT02518464
CompletedPhase 4United StatesColumbia University2015-10
Molecular and Functional PET-fMRI Measures of Analgesia in Migraine
NCT01970943
CompletedNot applicableUnited StatesMassachusetts General Hospital2012-09-01
Effect of Osteopathic Manipulative Treatment for Patients With Chronic Headache
NCT01332864
CompletedPhase 4United StatesWestern University of Health Sciences2011-03
Migraine--Investigational Treatment of Migraine With Noninvasive Brain Stimulation. (tDCS- Migraine)
NCT00521196
CompletedNot applicableUnited StatesBeth Israel Deaconess Medical Center2007-07

About Migraine

What is Migraine?

Migraine is a neurological condition with recurring headaches that are often throbbing and may come with nausea and sensitivity to light or sound. Chronic migraine usually refers to headache on 15 or more days a month for more than three months, with migraine features on at least eight of those days.

How is Migraine usually assessed?

Diagnosis is usually based on the pattern of symptoms described in a history and a neurological examination. A headache diary is often used. Tests may be done to rule out other causes.

What kinds of treatments are studied for Migraine?

Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.

How can I find Migraine clinical trials in Canada?

This page lists 4 registry records for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.

Related conditions

Related interventions

Related US FDA drug labels

Labels whose indications text mentions this term. US labels, not Health Canada Product Monographs.

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.