The Effect of Diet on Chronic Inflammation and Related Disorders Following Spinal Cord Injury
CompletedPhase 3NCT02099890
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Brief summary (from the registry)
Spinal cord Injury (SCI) is a condition commonly associated with a state of chronic low-grade inflammation due to a variety of factors such heightened risk for infection and development of metabolic disorders. Many disorders which have been demonstrated to have an inflammatory basis have also been found to be at much higher prevalence following SCI. Such conditions include, but are not limited to, depression, cognitive impairment, neuropathic pain, and somatic/autonomic nerve function. The fact that such disorders have an inflammatory basis provides a unique opportunity to treat them with intervention strategies which target the immune system. Natural anti-inflammatory interventions including a diet consisting of foods and supplements with anti-inflammatory properties may be an effective option for treating inflammation in this population. As this treatment strategy will target the inflammatory basis of many disorders it would be expected to lead to a reduction in pro-inflammatory mediators thereby leading to more sustainable long-term immune improvements regarding enzyme function and protein balances. Despite this, surprisingly little research has focused on the use of anti-inflammatory foods for the treatment of chronic inflammatory conditions, and effects specific to SCI have been almost completely neglected. As such, the current study will focus on the daily intake of natural supplements with anti-inflammatory properties over a 3 month intervention and the effects on inflammation and associated disorders will be assessed. It is hypothesized that the supplementation will result in positive alterations in enzyme regulation and protein balances resulting in improvements in each of the outcome measures of interest.
Study details
- Official title
- Neural Consequences of Chronic Inflammation in Individuals With Spinal Cord Injury and the Influence of an Anti-inflammatory Diet
- Conditions
- Neuropathic Pain
- Depression
- Cognitive Impairment
- Somatic Neuropathy
- Autonomic Dysfunction
- Interventions
- Dietary supplement: Omega-3
- Dietary supplement: Vegetation Protein Powder
- Dietary supplement: InflanNox
- Dietary supplement: Anti-oxidant Network
- Dietary supplement: Chlorella
- Sponsor
- Brock University
- Collaborators
- Ontario Neurotrauma Foundation
- Start date
- 2014-09
- Primary completion
- 2015-02
- Sex
- All
- Age range
- from 18 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- Canada
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Individuals with Spinal Cord Injury over the age of 18 Exclusion Criteria: * Any allergies / food intolerances to any supplements used in the study. Any participants who are pregnant, breast feeding, diabetic, or have kidney disease will also be excluded.
Canadian sites (1)
| Facility | City | Province |
|---|---|---|
| Brock University | St. Catharines | Ontario |
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT02099890