Depression: clinical trials and information
"Depression" is the term study registrants used on ClinicalTrials.gov. Registry labels are not always standard medical terms, and close variants of the same label appear as separate entries. In this snapshot the term appears on 96 chronic pain registry records worldwide.
5
Trials with Canadian sites
0
Recruiting in Canada
96
Registry records worldwide
Depression clinical trials in Canada
5 trials, recruiting first
| Phase | Provinces | ||||
|---|---|---|---|---|---|
| Meditation Versus Education for Improving Depression in Chronic Pain, a Randomized Controlled Trial NCT04039568 | Completed | Not applicable | Ontario | Mount Sinai Hospital, Canada | 2019-10-30 |
| Pain Self-management Program for Older Adults NCT03512522 | Completed | Not applicable | Saskatchewan | University of Regina | 2018-02-23 |
| Patient-Centred Innovations for Persons With Multimorbidity - Quebec NCT02789800 | Completed | Not applicable | Quebec | Université de Sherbrooke | 2016-04-22 |
| Patient-Centred Innovations for Persons With Multimorbidity - Ontario NCT02742597 | Completed | Not applicable | Ontario | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 2016-01-12 |
| The Effect of Diet on Chronic Inflammation and Related Disorders Following Spinal Cord Injury NCT02099890 | Completed | Phase 3 | Ontario | Brock University | 2014-09 |
Depression clinical trials worldwide (outside Canada)
91 trials, 10 recruiting or not yet recruiting. Recruiting first.
| Phase | Countries | ||||
|---|---|---|---|---|---|
| Virtual Reality-Based Hypnotherapy for Pain, Sleep, and Mood in Spinal Cord Injury NCT07846410 | Not yet recruiting | Not applicable | Turkey (Türkiye) | Istanbul Physical Medicine Rehabilitation Training and Research Hospital | 2026-10 |
| Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid Depression NCT06419439 | Recruiting | Phase 2 | United States | VA Office of Research and Development | 2025-12-03 |
| Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia NCT06644573 | Not yet recruiting | Phase 1 | United States | Nyree Penn | 2025-11-01 |
| Mindfulness-based Cognitive Therapy vs the Health Enhancement Program for Chronic Pain and Depression; The Quiet Focus Study NCT07118722 | Recruiting | Not applicable | United States | Massachusetts General Hospital | 2025-09-01 |
| Effects of Online Mindfulness Therapy on Pain and Stress in Adults With Chronic Migraine and Adverse Childhood Experiences NCT07033520 | Not yet recruiting | Not applicable | Colombia | Fundación Cardiovascular de Colombia | 2025-07-01 |
| Equipping Patients Using Interventions for Pain and Depression NCT06500780 | Recruiting | Not applicable | United States | Indiana University | 2024-08-13 |
| Psilocybin in Chronic Low Back Pain and Depression NCT06355414 | Recruiting | Phase 1 | United States | Johns Hopkins University | 2024-04-22 |
| Personalized Brain Stimulation to Treat Chronic Concussive Symptoms NCT06073886 | Recruiting | Phase 2 | United States | University of California, Los Angeles | 2024-03-06 |
| Evaluating the Impact of Focused Muscle Contraction Therapy in U.S. Veterans NCT05094297 | Recruiting | Not applicable | United States | University of Illinois at Chicago | 2021-10-01 |
| Evaluation of the PACE/PACENET BHL Clinical Program NCT02463266 | Recruiting | United States | University of Pennsylvania | 2014-03 | |
| Screening and Referral Practices for Anxiety and Depression Among Patients With Chronic Neck, Shoulder and Low Back Pain Within Physiotherapy Practices NCT07177547 | Active, not recruiting | Belgium | Ana Catarina Navarro Ramalho | 2025-05-05 | |
| Digital Implementation of the German S3 Clinical Practice Guideline for Multimorbidity NCT06831994 | Active, not recruiting | Not applicable | Germany | Universitätsklinikum Hamburg-Eppendorf | 2025-02-26 |
| Propofol-Enhanced Assessment of Ketamine for Chronic Pain and Depression NCT06317636 | Active, not recruiting | Phase 4 | United States | Stanford University | 2025-01-28 |
| Mindfulness-based Cognitive Therapy for the Chronic Pain-depression Co-morbidity Among Older Black Adults in the Community; The Quiet Focus Open Pilot NCT07336342 | Completed | Not applicable | United States | Massachusetts General Hospital | 2024-11-15 |
| Phase II Trial of Nu-V3 Non-Invasive Nerve Stimulation Device for Chronic Pain, Anxiety, Depression, Sleeplessness NCT05394545 | Suspended | Not applicable | United States | Nu-Life Solutions | 2024-03-20 |
| TCI-Massage Clinical Trial NCT07482358 | Active, not recruiting | Not applicable | United States | The Center for Victims of Torture, United States | 2024-02-01 |
| MOTIVATE to Improve Outcomes for Older Veterans With Musculoskeletal Pain and Depression NCT05220202 | Completed | Not applicable | United States | VA Office of Research and Development | 2023-09-20 |
| Equity Using Interventions for Pain and Depression - Pilot Study NCT05695209 | Completed | Not applicable | United States | Indiana University | 2023-06-22 |
| Repetitive Transcranial Magnetic Stimulation and Acceptance and Commitment Therapy NCT05427201 | Completed | Not applicable | United States | VA Office of Research and Development | 2023-05-22 |
| Pain Reduction Through Empowered Recovery (PRIME) Study NCT05619510 | Terminated | Not applicable | United States | Johns Hopkins University | 2023-03-31 |
| A Behavioral Intervention for Depression and Chronic Pain in Primary Care (Relief-Hybrid) NCT04290845 | Withdrawn | Not applicable | United States | Weill Medical College of Cornell University | 2023-02 |
| The Impact of Comorbid Chronic Pain on Older Adults With Depression in Behavioral Activation NCT05646628 | Unknown status | United Kingdom | Teesside University | 2022-11-28 | |
| What Concept of Manual Therapy is More Effective? NCT05559021 | Completed | Not applicable | Spain | Universidad Europea de Madrid | 2022-10-20 |
| VR Mindfulness Study NCT05592782 | Withdrawn | Not applicable | University of California, Los Angeles | 2022-10 | |
| Effects of Physical-Psychological Integrative Intervention on SCI Patient: a Pilot Randomized Controlled Trial NCT05535400 | Completed | Not applicable | Hong Kong | The Hong Kong Polytechnic University | 2022-09-20 |
| Transcranial Direct Current Stimulation Treatment for Warriors Experiencing Chronic Pain NCT05254379 | Completed | Not applicable | United States | Emory University | 2022-03-02 |
| EaseVRx-8w+ for the Treatment of Chronic Lower Back Pain NCT05263037 | Active, not recruiting | Not applicable | United States | AppliedVR Inc. | 2022-01-31 |
| Optimizing Mental Health in Orthopedic Care NCT05194722 | Completed | Not applicable | United States | Washington University School of Medicine | 2022-01-06 |
| Compassion Meditation vs. Health Education for Veterans NCT04651296 | Completed | Phase 2 | United States | VA Office of Research and Development | 2022-01-04 |
| Quest to Analyze One Thousand Humans Meditating NCT06583395 | Enrolling by invitation | United States | Tobias Moeller-Bertram | 2021-12-05 | |
| More Individualized Care: Assessment and Recovery Through Engagement NCT05122676 | Completed | Not applicable | United States | Kaiser Permanente | 2021-11-10 |
| The Relationship of Disability With Depression, Anxiety and Sleep Quality in Patients With Coccygodynia NCT05047380 | Unknown status | Turkey (Türkiye) | Cumhuriyet University | 2021-08-01 | |
| UK Prevalence of Mental Health After SCI NCT06618404 | Completed | United Kingdom | University of Reading | 2021-05-01 | |
| A Depression and Opioid Pragmatic Trial in Pharmacogenetics (DCRI Coordinating Center) NCT04445792 | Completed | Not applicable | United States | Duke University | 2021-02-24 |
| A Group Therapy Based on the Bio-psycho-social Treatment Approach for Women With Chronic Pelvic and Chronic Belly Pain NCT04057664 | Terminated | Switzerland | Swiss Paraplegic Research, Nottwil | 2020-09-01 | |
| Wellness Through Mobile Health NCT04640090 | Completed | Not applicable | United States | Washington University School of Medicine | 2020-08-12 |
| One-day Life Skills Workshop for Veterans With TBI, Pain, and Psychopathology: Evaluating Efficacy and Mechanism of Change NCT04143243 | Completed | Not applicable | United States | VA Office of Research and Development | 2020-07-01 |
| Evaluating the Impact of Focused Muscle Contraction Therapy in Retire APF Players NCT04822311 | Completed | Not applicable | United States | University of Illinois at Chicago | 2019-10-24 |
| Arts & Health Education to Improve Health, Resilience, and Well-Being NCT04154579 | Terminated | Not applicable | United States | Lisa Gallagher | 2019-07-01 |
| Pain Neuroscience Education for Depression NCT04023435 | Completed | Not applicable | United States | St. Ambrose University | 2019-06-01 |
| MOCHI: An RCT of Mindfulness as Treatment for Chronic Pelvic Pain in AD Women NCT04104542 | Completed | Not applicable | United States | University of Missouri, Kansas City | 2019-06-01 |
| Opioid Treatment and Recovery Through a Safe Pain Management Program NCT03889418 | Completed | Not applicable | United States | Ochsner Health System | 2019-04-01 |
| Improving Outcomes for Older Veterans With Chronic Back Pain and Depression NCT03896035 | Completed | Not applicable | United States | VA Office of Research and Development | 2019-03-28 |
| Music Therapy and Dialysis: A Pilot Investigation Into the Effectiveness of Patient-Selected Music Interventions on Physiological, Psychological, and Quality-of-Life Outcomes NCT03925168 | Completed | Not applicable | United States | Tulane University | 2019-03-08 |
| Outcomes Mandate National Integration With Cannabis as Medicine NCT03944447 | Unknown status | Phase 2 | United States | OMNI Medical Services, LLC | 2018-12-01 |
| Efficacy of a Blended Low Intensity Internet-delivered Psychological Program in Patients With Multimorbidity in Primary Care. NCT03426709 | Completed | Not applicable | Spain | Javier Garcia Campayo | 2018-11-26 |
| Determination of Chronic Pain, Anxiety, Depression and Perceived Stress in Adults With Temporomandibular Disorders NCT05183503 | Enrolling by invitation | Poland | Wroclaw Medical University | 2018-11-01 | |
| Impact of Modifiable Psychosocial Factors on Veterans' Long-term Trajectories of Functioning and Quality of Life NCT03615222 | Completed | United States | VA Office of Research and Development | 2018-10-01 | |
| Health Literacy Assessment and Intervention to Reduce Disparities: FLIGHT/VIDAS II NCT02922439 | Completed | Not applicable | United States | Nova Southeastern University | 2018-08-21 |
| Subgroups of Older Adults With Back Pain and Multiple Chronic Conditions NCT03632122 | Completed | United States | University of Washington | 2018-07-01 |
About Depression
What is Depression?
"Depression" is the term study registrants used on ClinicalTrials.gov. Registry labels are not always standard medical terms, and close variants of the same label appear as separate entries. In this snapshot the term appears on 96 chronic pain registry records worldwide.
How is Depression usually assessed?
Assessment of chronic pain generally involves a clinician taking a detailed history, a physical examination and, where relevant, tests to look for underlying causes. Pain rating scales and questionnaires about function, sleep and mood are often used. The approach depends on the person and the condition.
What kinds of treatments are studied for Depression?
Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.
How can I find Depression clinical trials in Canada?
This page lists 5 registry records for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.
Related interventions
- Drug: placebo (3)
- Behavioral: Health Education (2)
- Procedure: pain therapy (1)
- Procedure: psychosocial assessment and care (1)
- Behavioral: Cognitive behavioral therapy (1)
- Device: rTMS (1)
- Device: Sham rTMS (1)
- Other: Observation (1)
- Behavioral: Education (1)
- Other: Standard Care (1)
- Drug: Oxycodone (1)
- Drug: morphine (1)
- Other: Health Education (1)
- Other: Questionnaire Administration (1)
- Drug: duloxetine (1)
- Drug: Diphenhydramine (1)
- Other: Acupuncture (1)
- Behavioral: Music Therapy (1)
- Behavioral: Mindfulness Based Stress Reduction (1)
- Other: dry needling (1)
Related US FDA drug labels
Labels whose indications text mentions this term. US labels, not Health Canada Product Monographs.
- Morphine sulfate solution
- Morphine sulfate oral solution (10 mg per 5 mL and 20 mg per 5 mL)
- Morphine sulfate solution
- Oxycodone Hydrochloride Solution USP, 100 mg per 5 mL ( )
- Oxycodone Hydrochloride Oral Solution USP, 100 mg per 5 mL ( 20 mg/mL )
- Morphine sulfate oral solution (10 mg per 5 mL and 20 mg per 5 mL)
- Oxycodone hydrochloride oral solution 100 mg/5 mL ( 20 mg/mL )
- Morphine sulfate oral solution 100 mg per 5 mL (20 mg/mL)
- Morphine sulfate oral solution (10 mg per 5 mL and 20 mg per 5 mL)
- FDA drug label fb100a73
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.