Chronic Pain Risk Associated With Menstrual Period Pain
CompletedPhase 4NCT02214550
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The purpose of this study is to determine if some women with dysmenorrhea (painful periods) are at higher future risk of developing chronic pelvic pain (CPP) and if oral contraceptives (OC) can be used to reverse this chronic pain risk. Investigators will examine whether dysmenorrhea produces CPP via repetitive cross organ sensitization (COS) episodes. The use of cyclical OCs to eliminate dysmenorrhea is expected to reduce COS and decrease the risk of developing CPP.
Study details
- Official title
- Deciphering the Hormonal and Nociceptive Mechanisms Underlying Bladder Pain
- Conditions
- Cystitis, Interstitial
- Dysmenorrhea
- Migraine Disorders
- Pelvic Pain
- Endometriosis
- Visceral Pain
- Chronic Pain
- Interventions
- Drug: cyclic microgestin 1/20
- Drug: continuous microgestin 1/20
- Sponsor
- Endeavor Health
- Collaborators
- National Institutes of Health (NIH); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Start date
- 2014-07
- Primary completion
- 2020-11
- Sex
- Female
- Age range
- from 18 Years to 45 Years
- Healthy volunteers
- true
- Results posted
- Yes, on ClinicalTrials.gov
- Countries
- United States
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: All * Reproductive age women (18-45) For dysmenorrhea and D+COS group only: * Participants must have had regular (22-45 day) menstrual cycles over at least a two month period preceding testing Exclusion Criteria: All * presence of active pelvic or abdominal malignancies (primary or metastatic) * active genitourinary infection in the last four weeks * unable to read or comprehend the informed consent in English * unwilling to undergo pelvic examination/testing * presence of hypertension or risk for developing hypertension, and For dysmenorrhea and D+COS group only: * absence of regular menses (including current pregnancy, recent pregnancy, or active breast feeding) unwilling to take either cyclic or combined OCs * unwilling to withdraw from OCs for two months prior to the sensory testing study visit.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT02214550