Neuroscience Education on Osteoarthritis
Unknown statusNot applicableNCT02246088
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Osteoarthritis (OA) is a frequent chronic musculoskeletal pathology that usually causes great disability and significant healthcare costs. Substantial scientific evidence indicates a role for central sensitization in OA pain. Reconceptualization of pain through Neuroscience Education (NE) is an intervention that has already been used successfully in some chronic musculoskeletal pain conditions characterized by alteration on CNS pain processing or central sensitization (i.e. chronic low back pain, chronic fatigue syndrome, widespread pain and chronic whiplash associate disorders).There is compelling evidence that NE have a positive effect on pain, disability, catastrophization and physical performance for chronic musculoskeletal pain disorders, yet studies examining the value of NE for OA patients are essentially lacking. The primary aim of this study is to assess the effect of NE on pain, disability and physical performance in subjects with chronic OA knee pain waiting for replacement surgery. This will be the first time NE will be addressed specifically to OA pain. To investigate the benefits of NE on pain related to knee OA, the effect of a manual therapy intervention combined with NE (MT+NE) will be compared with this same manual intervention plus an educational program based on a traditional patho-anatomical or biomedical model (MT+E). The following secondary aims will be addressed as well: * Examining the effects of the two interventions on the mechanism of central sensitization in patients with knee OA; * Examining the effects of the two interventions on pain catastrophizing, illness perceptions and kinesiophobia in patients with knee OA; * Finally, it is aimed at identifying effect moderators for NE in patients with knee OA.
Study details
- Official title
- Effect of Neuroscience Education on Subjects With Chronic Knee Pain Related to Osteoarthritis : a Randomized Controlled Trial
- Conditions
- Interventions
- Procedure: MT + NE
- Procedure: MT + E
- Sponsor
- University of Valencia
- Collaborators
- Hospital de la Ribera
- Start date
- 2013-12
- Primary completion
- 2015-12
- Sex
- All
- Results posted
- No results posted in this snapshot
- Countries
- Spain
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: 1. An established diagnosis of knee OA according to American College of Rheumatology criteria and Kellgreen/Lawrence scale grades. 2. To be in a waiting list and scheduled to undergo primary knee arthroplasty. 3. To have sufficient Spanish language skills to comprehend all explanations and to complete the assessment tools. Exclusion Criteria: 1. Previous knee joint replacement surgery of the affected joint or any other lower limb surgery within the past 6 months. 2. Stated inability to attend or complete the proposed course of intervention and follow-up schedule. 3. Presence of co-morbidities associated with cognitive impairment. 4. Co-existing inflammatory, metabolic, neurological or severe medical conditions, defined as a diagnosis in the medical record severe enough that the patient cannot participate fully in the study procedures (i.e. cardiovascular disease). 5. Functional illiteracy.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT02246088