Osteoarthritis: clinical trials and information
Osteoarthritis clinical trials in Canada
| Phase | Provinces | ||||
|---|---|---|---|---|---|
| Physiological Impact of Different Types of Osteoarthritis Education. NCT06400329 | Completed | Not applicable | Ontario | Lisa Carlesso | 2024-08-15 |
| Cryoneurolysis for TKA - a Pilot Study NCT05286996 | Unknown status | Not applicable | Ontario | Unity Health Toronto | 2022-12-01 |
| Subchondroplasty® Knee RCT NCT03112200 | Completed | Not applicable | Ontario | Zimmer Biomet | 2017-03-29 |
| Detecting and Addressing Preclinical Disability NCT01979081 | Completed | Ontario | McMaster University | 2013-01 | |
| A Safety and Tolerability Study of JNJ-42160443 in Patients With Moderate to Severe, Chronic Knee Pain From Osteoarthritis NCT01094262 | Terminated | Phase 2 | Ontario, Quebec | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | 2010-04-20 |
| A Dose-ranging Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Osteoarthritis-related Pain NCT00973141 | Terminated | Phase 2 | British Columbia, Newfoundland and Labrador, Ontario, Quebec | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | 2009-09-16 |
| An Open-label Extension Study With Flexible Dosing of Extended-release (ER) Tapentadol (CG5503) to Treat Patients With Moderate to Severe Chronic Pain NCT00487435 | Completed | Phase 3 | British Columbia, Newfoundland and Labrador, Ontario, Prince Edward Island, Quebec, Saskatchewan | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | 2007-06 |
Osteoarthritis clinical trials worldwide (outside Canada)
91 trials, 6 recruiting or not yet recruiting. Recruiting first.
| Phase | Countries | ||||
|---|---|---|---|---|---|
| Ketogenic Diet to Reduce Osteoarthritis Pain in MCI NCT07417891 | Not yet recruiting | Not applicable | United States | University of Kansas Medical Center | 2026-06-01 |
| Integrated Healthy Lifestyle and Pain Care for People With Musculoskeletal Conditions Living in Rural Areas. NCT07173335 | Recruiting | Not applicable | Australia | University of Sydney | 2025-09-17 |
| "Bimodal vs Unimodal High-Intensity Pulsed Electromagnetic Field Therapy in Older Adults With Knee Osteoarthritis" NCT07198750 | Recruiting | Not applicable | Mexico | Hospital Civil de Guadalajara | 2025-09-15 |
| A Mobile Intervention to Reduce Pain and Improve Health-III NCT06623669 | Recruiting | Phase 2 | United States | Wake Forest University | 2025-08-14 |
| The Beat Pain Better Trial NCT06932887 | Recruiting | Phase 3 | United States | University of Utah | 2025-05-28 |
| The PROACTIVE Study for Black Elders NCT06512727 | Recruiting | Not applicable | United States | University of Florida | 2025-05-07 |
| Genicular Embolization Using Doxycycline Sclerotherapy NCT07024654 | Withdrawn | Phase 2 | Campbell Clinic | 2026-06 | |
| Assessing Central Aspects of Pain NCT06518278 | Active, not recruiting | United Kingdom | University of Nottingham | 2024-10-23 | |
| Sequential Genicular Nerve Ablation Prior to Geniculate Artery Embolization in Knee Pain NCT06514755 | Completed | Not applicable | Egypt | Zagazig University | 2024-09-29 |
| Cemented vs Cementless Persona Keel RCT NCT05630053 | Active, not recruiting | Not applicable | United States | Zimmer Biomet | 2023-07-25 |
| Transcatheter Arterial Micro-Embolization (TAME) Using Nexsphere-F in Patients With Chronic Pain in Elbow or Wrist NCT06207851 | Unknown status | Not applicable | South Korea | Next Biomedical Co., Ltd. | 2023-07-13 |
| The Living With a Long-Term Condition Study NCT06072287 | Unknown status | United Kingdom | King's College London | 2023-06-28 | |
| A Randomized Controlled Trial for Partial Knee Arthroplasty NCT05037734 | Withdrawn | Not applicable | United States | Zimmer Biomet | 2023-06 |
| Pain Management In Knee Osteoarthritis NCT05844319 | Unknown status | Not applicable | Turkey (Türkiye) | Istanbul University | 2023-05-01 |
| A Chronic Pain Master Protocol (CPMP): A Study of LY3857210 In Participants With Osteoarthritis Pain NCT05620563 | Completed | Phase 2 | Puerto Rico, United States | Eli Lilly and Company | 2022-11-22 |
| A MAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers and PHN Patients. NCT06218784 | Unknown status | Phase 1 | Australia | iN Therapeutics Co., Ltd. | 2022-11-11 |
| Investigating RELEARN Neurofeedback as Treatment for Chronic Musculoskeletal Pain NCT05335486 | Withdrawn | Phase 2, Phase 3 | Denmark | Redo-Neurosystems | 2022-10-05 |
| Evolution of the State of Health of Patients Undergoing Surgery for Osteoarticular Surgery NCT05527860 | Unknown status | France | University Hospital, Strasbourg, France | 2022-08-08 | |
| A Study of the Feasibility of Using the Dietary Supplement "ARTNEO" in Patients With Osteoathritis NCT05975879 | Completed | Not applicable | Russia | NPO Petrovax | 2022-05-31 |
| Intra-articular Pulsed Radiofrequency in Chronic Knee Pain NCT06017674 | Completed | Not applicable | Turkey (Türkiye) | Başakşehir Çam & Sakura City Hospital | 2022-05-01 |
| Quest to Analyze One Thousand Humans Meditating NCT06583395 | Enrolling by invitation | United States | Tobias Moeller-Bertram | 2021-12-05 | |
| Chronic Pain Master Protocol (CPMP): A Study of LY3526318 in Participants With Osteoarthritis NCT05080660 | Completed | Phase 2 | Puerto Rico, United States | Eli Lilly and Company | 2021-10-12 |
| Persona Ti-Nidium Post-Market Clinical Follow-up NCT04817969 | Active, not recruiting | Not applicable | United States | Zimmer Biomet | 2021-06-01 |
| Trichomylin® Safety, Tolerability & Pharmacokinetics in Healthy Adults and First in Human Osteoarthritis Pain Evaluation NCT04867057 | Completed | Phase 1 | Australia | ZYUS Life Sciences Inc. | 2021-04-19 |
| Chronic Pain Master Protocol (CPMP): A Study of LY3556050 in Participants With Osteoarthritis NCT04627038 | Completed | Phase 2 | Puerto Rico, United States | Eli Lilly and Company | 2020-11-12 |
| A SAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers NCT05496205 | Completed | Phase 1 | Australia | iN Therapeutics Co., Ltd. | 2020-09-30 |
| Chronic Pain Master Protocol (CPMP): A Study of LY3016859 in Participants With Osteoarthritis NCT04456686 | Completed | Phase 2 | Puerto Rico, United States | Eli Lilly and Company | 2020-07-01 |
| Low Dose Naltrexone for Chronic Pain in Osteoarthritis and Inflammatory Arthritis NCT04115020 | Withdrawn | Phase 2 | United States | Brigham and Women's Hospital | 2020-01 |
| Effectiveness of Curcumin-based Food Supplement in Reducing Pain and Inflammatory Component in Osteoarthritis NCT04207021 | Unknown status | Not applicable | KOS Care SRL - Istituto di Riabilitazione Santo Stefano | 2019-12-18 | |
| Manual Therapy and Strengthening for the Hip in Older Adults With Chronic Low Back Pain NCT04009837 | Completed | Not applicable | United States | University of Delaware | 2019-11-01 |
| Chronic Pain, Couples, & Physical Activity NCT04077164 | Terminated | United States | Illinois Institute of Technology | 2019-04-09 | |
| Audio-visual Stimulation: Sleep Dose Response NCT03569865 | Completed | Not applicable | United States | University of Washington | 2019-03-15 |
| Predicting Successful Outcome of Interdisciplinary Biopsychosocial Rehabilitation in Osteoarthritis NCT05661760 | Unknown status | Netherlands | Maastricht University | 2019-01-01 | |
| Subgroups of Older Adults With Back Pain and Multiple Chronic Conditions NCT03632122 | Completed | United States | University of Washington | 2018-07-01 | |
| Low Dose Naltrexone for Chronic Pain From Arthritis NCT03008590 | Completed | Phase 2 | United States | VA Office of Research and Development | 2018-05-01 |
| Evaluate the Efficacy and Safety of Fasinumab in Patients With Moderate-to-Severe Chronic Low Back Pain and Osteoarthritis of the Hip or Knee NCT03285646 | Terminated | Phase 3 | United States | Regeneron Pharmaceuticals | 2017-10-30 |
| Trial Outcomes for Massage: Caregiver-Assisted vs. Therapist-Treated NCT03100539 | Completed | Not applicable | United States | VA Office of Research and Development | 2017-05-01 |
| Virtual Environment Rehabilitation for Patients With Motor Neglect Trial NCT03887962 | Unknown status | Not applicable | United Kingdom | Cambridge University Hospitals NHS Foundation Trust | 2017-05-01 |
| A Study to Investigate the Genetic Variation of Dopamine Pathway in Patients With Chronic Pain NCT02989792 | Completed | Not applicable | Belgium, France | Tools4Patient | 2017-02-08 |
| Effects of tDCS and tUS on Pain Perception in OA of the Knee NCT02723929 | Active, not recruiting | United States | Spaulding Rehabilitation Hospital | 2016-09 | |
| Mindfulness for Osteoarthritis-related Knee Pain NCT02595099 | Completed | Not applicable | University of Nottingham | 2016-05-20 | |
| Optimizing Chronic Pain Treatment With Enhanced Neuroplastic Responsiveness NCT02681081 | Completed | Not applicable | United States | University of Florida | 2016-02 |
| Study to Evaluate the Safety and Efficacy of CNTX-4975 in Subjects With Chronic, Moderate to Severe Osteoarthritis Knee Pain NCT02558439 | Completed | Phase 2 | United States | Centrexion Therapeutics | 2015-08 |
| fMRI and Central Sensitization in Chronic Knee Osteoarthritis. A Pre and Post TKR Study NCT03126279 | Unknown status | United Kingdom | University of Nottingham | 2015-08 | |
| A Proof of Concept Study to Investigate the Effect of a New Treatment in Patient With Chronic Pain NCT02459197 | Completed | Not applicable | Belgium, France | Tools4Patient | 2015-06 |
| Acupuncture Approaches for Chronic Pain NCT02456727 | Completed | Not applicable | United States | Albert Einstein College of Medicine | 2015-05 |
| PatientSpot Formerly Known as ArthritisPower NCT03840928 | Unknown status | United States | Global Healthy Living Foundation | 2015-04-01 | |
| Effects of tDCS and tUS on Pain Perception in OA of the Knee NCT02330315 | Completed | Not applicable | United States | Spaulding Rehabilitation Hospital | 2015-03 |
| Imaging Pain Relief in Osteoarthritis NCT02208778 | Completed | Phase 4 | United Kingdom | University of Nottingham | 2014-12 |
| Audio-visual Stimulation for Sleep Promotion in Older Adults With Osteoarthritis Pain NCT03441191 | Completed | Not applicable | University of Washington | 2014-10-01 |
About Osteoarthritis
What is Osteoarthritis?
Osteoarthritis is the most common form of arthritis. It involves breakdown of cartilage and changes in the bone and tissues of a joint, most often in the knees, hips, hands and spine, and can cause pain, stiffness and reduced movement.
How is Osteoarthritis usually assessed?
Clinicians usually assess osteoarthritis through a history, physical examination of the joint and, in some cases, X-rays. Blood tests may help rule out other types of arthritis.
What kinds of treatments are studied for Osteoarthritis?
Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.
How can I find Osteoarthritis clinical trials in Canada?
This page lists 7 registry records for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.
Related conditions
Related interventions
- Drug: placebo (15)
- Drug: JNJ-42160443 (7)
- Drug: Buprenorphine transdermal patch (4)
- Drug: Buprenorphine transdermal delivery system (2)
- Drug: HZT-501 (2)
- Drug: Fentanyl (2)
- Drug: duloxetine (2)
- Dietary supplement: Placebo (2)
- Procedure: acupuncture (1)
- Drug: Buprenorphine (1)
- Drug: Tramadol (1)
- Drug: Ibuprofen (1)
- Drug: Oxycodone/Naloxone (1)
- Drug: Sugar pill (1)
- Drug: Tapentadol PR (1)
- Drug: Tapentadol (1)
- Device: TENS (1)
- Device: transcranial direct current stimulation (1)
- Drug: Remifentanil (1)
- Device: Transcranial Direct Current Stimulation (tDCS) (1)
Related US FDA drug labels
Labels whose indications text mentions this term. US labels, not Health Canada Product Monographs.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.