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Osteoarthritis: clinical trials and information

Osteoarthritis is the most common form of arthritis. It involves breakdown of cartilage and changes in the bone and tissues of a joint, most often in the knees, hips, hands and spine, and can cause pain, stiffness and reduced movement.
7
Trials with Canadian sites
0
Recruiting in Canada
98
Registry records worldwide

Osteoarthritis clinical trials in Canada

7 trials, recruiting first
PhaseProvinces
Physiological Impact of Different Types of Osteoarthritis Education.
NCT06400329
CompletedNot applicableOntarioLisa Carlesso2024-08-15
Cryoneurolysis for TKA - a Pilot Study
NCT05286996
Unknown statusNot applicableOntarioUnity Health Toronto2022-12-01
Subchondroplasty® Knee RCT
NCT03112200
CompletedNot applicableOntarioZimmer Biomet2017-03-29
Detecting and Addressing Preclinical Disability
NCT01979081
CompletedOntarioMcMaster University2013-01
A Safety and Tolerability Study of JNJ-42160443 in Patients With Moderate to Severe, Chronic Knee Pain From Osteoarthritis
NCT01094262
TerminatedPhase 2Ontario, QuebecJohnson & Johnson Pharmaceutical Research & Development, L.L.C.2010-04-20
A Dose-ranging Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Osteoarthritis-related Pain
NCT00973141
TerminatedPhase 2British Columbia, Newfoundland and Labrador, Ontario, QuebecJohnson & Johnson Pharmaceutical Research & Development, L.L.C.2009-09-16
An Open-label Extension Study With Flexible Dosing of Extended-release (ER) Tapentadol (CG5503) to Treat Patients With Moderate to Severe Chronic Pain
NCT00487435
CompletedPhase 3British Columbia, Newfoundland and Labrador, Ontario, Prince Edward Island, Quebec, SaskatchewanJohnson & Johnson Pharmaceutical Research & Development, L.L.C.2007-06

Osteoarthritis clinical trials worldwide (outside Canada)

91 trials, 6 recruiting or not yet recruiting. Recruiting first.

PhaseCountries
Ketogenic Diet to Reduce Osteoarthritis Pain in MCI
NCT07417891
Not yet recruitingNot applicableUnited StatesUniversity of Kansas Medical Center2026-06-01
Integrated Healthy Lifestyle and Pain Care for People With Musculoskeletal Conditions Living in Rural Areas.
NCT07173335
RecruitingNot applicableAustraliaUniversity of Sydney2025-09-17
"Bimodal vs Unimodal High-Intensity Pulsed Electromagnetic Field Therapy in Older Adults With Knee Osteoarthritis"
NCT07198750
RecruitingNot applicableMexicoHospital Civil de Guadalajara2025-09-15
A Mobile Intervention to Reduce Pain and Improve Health-III
NCT06623669
RecruitingPhase 2United StatesWake Forest University2025-08-14
The Beat Pain Better Trial
NCT06932887
RecruitingPhase 3United StatesUniversity of Utah2025-05-28
The PROACTIVE Study for Black Elders
NCT06512727
RecruitingNot applicableUnited StatesUniversity of Florida2025-05-07
Genicular Embolization Using Doxycycline Sclerotherapy
NCT07024654
WithdrawnPhase 2Campbell Clinic2026-06
Assessing Central Aspects of Pain
NCT06518278
Active, not recruitingUnited KingdomUniversity of Nottingham2024-10-23
Sequential Genicular Nerve Ablation Prior to Geniculate Artery Embolization in Knee Pain
NCT06514755
CompletedNot applicableEgyptZagazig University2024-09-29
Cemented vs Cementless Persona Keel RCT
NCT05630053
Active, not recruitingNot applicableUnited StatesZimmer Biomet2023-07-25
Transcatheter Arterial Micro-Embolization (TAME) Using Nexsphere-F in Patients With Chronic Pain in Elbow or Wrist
NCT06207851
Unknown statusNot applicableSouth KoreaNext Biomedical Co., Ltd.2023-07-13
The Living With a Long-Term Condition Study
NCT06072287
Unknown statusUnited KingdomKing's College London2023-06-28
A Randomized Controlled Trial for Partial Knee Arthroplasty
NCT05037734
WithdrawnNot applicableUnited StatesZimmer Biomet2023-06
Pain Management In Knee Osteoarthritis
NCT05844319
Unknown statusNot applicableTurkey (Türkiye)Istanbul University2023-05-01
A Chronic Pain Master Protocol (CPMP): A Study of LY3857210 In Participants With Osteoarthritis Pain
NCT05620563
CompletedPhase 2Puerto Rico, United StatesEli Lilly and Company2022-11-22
A MAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers and PHN Patients.
NCT06218784
Unknown statusPhase 1AustraliaiN Therapeutics Co., Ltd.2022-11-11
Investigating RELEARN Neurofeedback as Treatment for Chronic Musculoskeletal Pain
NCT05335486
WithdrawnPhase 2, Phase 3DenmarkRedo-Neurosystems2022-10-05
Evolution of the State of Health of Patients Undergoing Surgery for Osteoarticular Surgery
NCT05527860
Unknown statusFranceUniversity Hospital, Strasbourg, France2022-08-08
A Study of the Feasibility of Using the Dietary Supplement "ARTNEO" in Patients With Osteoathritis
NCT05975879
CompletedNot applicableRussiaNPO Petrovax2022-05-31
Intra-articular Pulsed Radiofrequency in Chronic Knee Pain
NCT06017674
CompletedNot applicableTurkey (Türkiye)Başakşehir Çam & Sakura City Hospital2022-05-01
Quest to Analyze One Thousand Humans Meditating
NCT06583395
Enrolling by invitationUnited StatesTobias Moeller-Bertram2021-12-05
Chronic Pain Master Protocol (CPMP): A Study of LY3526318 in Participants With Osteoarthritis
NCT05080660
CompletedPhase 2Puerto Rico, United StatesEli Lilly and Company2021-10-12
Persona Ti-Nidium Post-Market Clinical Follow-up
NCT04817969
Active, not recruitingNot applicableUnited StatesZimmer Biomet2021-06-01
Trichomylin® Safety, Tolerability & Pharmacokinetics in Healthy Adults and First in Human Osteoarthritis Pain Evaluation
NCT04867057
CompletedPhase 1AustraliaZYUS Life Sciences Inc.2021-04-19
Chronic Pain Master Protocol (CPMP): A Study of LY3556050 in Participants With Osteoarthritis
NCT04627038
CompletedPhase 2Puerto Rico, United StatesEli Lilly and Company2020-11-12
A SAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers
NCT05496205
CompletedPhase 1AustraliaiN Therapeutics Co., Ltd.2020-09-30
Chronic Pain Master Protocol (CPMP): A Study of LY3016859 in Participants With Osteoarthritis
NCT04456686
CompletedPhase 2Puerto Rico, United StatesEli Lilly and Company2020-07-01
Low Dose Naltrexone for Chronic Pain in Osteoarthritis and Inflammatory Arthritis
NCT04115020
WithdrawnPhase 2United StatesBrigham and Women's Hospital2020-01
Effectiveness of Curcumin-based Food Supplement in Reducing Pain and Inflammatory Component in Osteoarthritis
NCT04207021
Unknown statusNot applicableKOS Care SRL - Istituto di Riabilitazione Santo Stefano2019-12-18
Manual Therapy and Strengthening for the Hip in Older Adults With Chronic Low Back Pain
NCT04009837
CompletedNot applicableUnited StatesUniversity of Delaware2019-11-01
Chronic Pain, Couples, & Physical Activity
NCT04077164
TerminatedUnited StatesIllinois Institute of Technology2019-04-09
Audio-visual Stimulation: Sleep Dose Response
NCT03569865
CompletedNot applicableUnited StatesUniversity of Washington2019-03-15
Predicting Successful Outcome of Interdisciplinary Biopsychosocial Rehabilitation in Osteoarthritis
NCT05661760
Unknown statusNetherlandsMaastricht University2019-01-01
Subgroups of Older Adults With Back Pain and Multiple Chronic Conditions
NCT03632122
CompletedUnited StatesUniversity of Washington2018-07-01
Low Dose Naltrexone for Chronic Pain From Arthritis
NCT03008590
CompletedPhase 2United StatesVA Office of Research and Development2018-05-01
Evaluate the Efficacy and Safety of Fasinumab in Patients With Moderate-to-Severe Chronic Low Back Pain and Osteoarthritis of the Hip or Knee
NCT03285646
TerminatedPhase 3United StatesRegeneron Pharmaceuticals2017-10-30
Trial Outcomes for Massage: Caregiver-Assisted vs. Therapist-Treated
NCT03100539
CompletedNot applicableUnited StatesVA Office of Research and Development2017-05-01
Virtual Environment Rehabilitation for Patients With Motor Neglect Trial
NCT03887962
Unknown statusNot applicableUnited KingdomCambridge University Hospitals NHS Foundation Trust2017-05-01
A Study to Investigate the Genetic Variation of Dopamine Pathway in Patients With Chronic Pain
NCT02989792
CompletedNot applicableBelgium, FranceTools4Patient2017-02-08
Effects of tDCS and tUS on Pain Perception in OA of the Knee
NCT02723929
Active, not recruitingUnited StatesSpaulding Rehabilitation Hospital2016-09
Mindfulness for Osteoarthritis-related Knee Pain
NCT02595099
CompletedNot applicableUniversity of Nottingham2016-05-20
Optimizing Chronic Pain Treatment With Enhanced Neuroplastic Responsiveness
NCT02681081
CompletedNot applicableUnited StatesUniversity of Florida2016-02
Study to Evaluate the Safety and Efficacy of CNTX-4975 in Subjects With Chronic, Moderate to Severe Osteoarthritis Knee Pain
NCT02558439
CompletedPhase 2United StatesCentrexion Therapeutics2015-08
fMRI and Central Sensitization in Chronic Knee Osteoarthritis. A Pre and Post TKR Study
NCT03126279
Unknown statusUnited KingdomUniversity of Nottingham2015-08
A Proof of Concept Study to Investigate the Effect of a New Treatment in Patient With Chronic Pain
NCT02459197
CompletedNot applicableBelgium, FranceTools4Patient2015-06
Acupuncture Approaches for Chronic Pain
NCT02456727
CompletedNot applicableUnited StatesAlbert Einstein College of Medicine2015-05
PatientSpot Formerly Known as ArthritisPower
NCT03840928
Unknown statusUnited StatesGlobal Healthy Living Foundation2015-04-01
Effects of tDCS and tUS on Pain Perception in OA of the Knee
NCT02330315
CompletedNot applicableUnited StatesSpaulding Rehabilitation Hospital2015-03
Imaging Pain Relief in Osteoarthritis
NCT02208778
CompletedPhase 4United KingdomUniversity of Nottingham2014-12
Audio-visual Stimulation for Sleep Promotion in Older Adults With Osteoarthritis Pain
NCT03441191
CompletedNot applicableUniversity of Washington2014-10-01

About Osteoarthritis

What is Osteoarthritis?

Osteoarthritis is the most common form of arthritis. It involves breakdown of cartilage and changes in the bone and tissues of a joint, most often in the knees, hips, hands and spine, and can cause pain, stiffness and reduced movement.

How is Osteoarthritis usually assessed?

Clinicians usually assess osteoarthritis through a history, physical examination of the joint and, in some cases, X-rays. Blood tests may help rule out other types of arthritis.

What kinds of treatments are studied for Osteoarthritis?

Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.

How can I find Osteoarthritis clinical trials in Canada?

This page lists 7 registry records for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.

Related conditions

Related interventions

Related US FDA drug labels

Labels whose indications text mentions this term. US labels, not Health Canada Product Monographs.

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.