Does Duloxetine Reduce Chronic Pain After Total Knee Arthroplasty?

Brief summary (from the registry)

Range from 24% to 44%, with a prevalence of neuropathic-type pain from 6% to 20%-cause impairment in quality of life and functional capacity after total knee arthroplasty(TKA). Duloxetine (cymbalta) is a selective serotonin and nor-epinephrine reuptake inhibitor shown to be effective in treating chronic pain. Serotonin and norepinephrine in the brain and spinal cord are believed to both mediate core mood symptoms and help regulate the perception of pain. Its effects on depression and anxiety symptoms, as well as its effect on pain perception, may be due to increasing the activity of serotonin and norepinephrine in the central nervous system. Approved for the acute and maintenance treatment of major depressive disorder, the acute treatment of generalized anxiety disorder, the management of diabetic peripheral neuropathic pain and the management of fibromyalgia, all in adults (18+). Investigators will compare the neuropathic pain following TKA in duloxetine group (n=84) with those in non-duloxetine group (n=84). Investigators will classify the participants in to 2 groups (duloxetine and non-duloxetine group) randomly, and primarily evaluate the degree of neuropathic pain using the S-LANSS pain scale (preoperatively and postoperatively 3 and 6 months). All participants will receive postoperative pain control after TKA using the same pain control regimen except duloxetine.

Study details

Official title

Does Duloxetine Reduce Chronic Pain After Total Knee Arthroplasty?

Conditions

• Neuropathic Pain

Interventions

• Drug: Duloxetine
• Drug: celecoxib, naproxen/esomeprazole, acetaminophen/tramadol, oxycodone/naloxone

Sponsor

Hanyang University Seoul Hospital

Start date

2014-08

Primary completion

2016-12

Sex

All

Age range

from 50 Years to 75 Years

Results posted

No results posted in this snapshot

Countries

South Korea

Total sites listed

1

Eligibility criteria