Drug: duloxetine: chronic pain clinical trials

Registry records that list "Drug: duloxetine" as an intervention. Being studied does not mean an intervention works or is approved.

Trials with Canadian sites

Recruiting in Canada

Registry records in total

Trials in Canada

No trial with a Canadian site lists this intervention in this snapshot.

Trials worldwide (outside Canada)

32 trials, 2 recruiting or not yet recruiting. Recruiting first.

		Phase	Countries
Personalized Analgesia Through Central Nervous System Engagement to Unlock Performance NCT07759336	Not yet recruiting	Phase 4	United States	Benedict Alter	2026-08
Algorithm-informed Decision-making to Advance Pain Treatment NCT07731750	Recruiting	Not applicable	United States	University of Michigan	2026-07-23
Duloxetine to Prevent Chronic Postsurgical Pain After Inguinal Hernia Repair in Patients at High Risk NCT06606067	Active, not recruiting	Phase 3	Spain	Parc de Salut Mar	2024-09-03
Pain Relieving Potentials of Combination of Oral Duloxetine and Intravenous Magnesium Sulphate in Post Mastectomy Pain NCT06087211	Completed	Not applicable	Egypt	National Cancer Institute, Egypt	2023-10-10
The BEST Trial: Biomarkers for Evaluating Spine Treatments NCT05396014	Completed	Phase 4	United States	University of North Carolina, Chapel Hill	2022-09-12
Duloxetine on Bone Metabolism NCT05550506	Unknown status		Turkey (Türkiye)	Cukurova University	2022-07-27
The Back Pain Consortium Research Program Study NCT04870957	Completed	Phase 4	United States	University of Michigan	2021-06-09
Duloxetine vs Pregabalin for Thoracotomy Pain NCT04782310	Unknown status	Phase 4	Egypt	Cairo University	2021-03-10
Pain Response Evaluation of a Combined Intervention to Cope Effectively NCT04395001	Completed	Phase 4	United States	Wake Forest University Health Sciences	2021-02-24
Duloxetine Combined With Intra-articular Injection of Corticosteroid and Hyaluronic Acid Reduces Pain in the Treatment of Knee Osteoarthritis Patients NCT04117893	Completed	Phase 4	China	Beijing Tiantan Hospital	2019-10-01
Comparing Effectiveness of Duloxetine and Desipramine in Patients With Chronic Pain: A Pragmatic Trial Using Point of Care Randomization NCT03548454	Completed	Phase 4	United States	Stanford University	2018-09-20
Effect of Combined Morphine and Duloxetine on Chronic Pain NCT03249558	Completed	Phase 4	United States	Massachusetts General Hospital	2018-03-12
Determination of the Antidepressant Duloxetine in Plasma to Improve the Knowledge of the Analgesic Action of Antidepressants on Chronic Neuropathic Pain NCT02846701	Completed	Phase 4		University Hospital, Strasbourg, France	2016-11-17
Shifting Pain Modulation From Pro-to Anti-nociceptive NCT02672202	Terminated	Not applicable		Rambam Health Care Campus	2016-02
A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity NCT02655354	Completed	Not applicable	United States	University of Washington	2015-10
Imaging Pain Relief in Osteoarthritis NCT02208778	Completed	Phase 4	United Kingdom	University of Nottingham	2014-12
A Study of Duloxetine (LY248686) in Participants With Chronic Osteoarthritis and Knee Pain in Japan NCT02248480	Completed	Phase 3	Japan	Eli Lilly and Company	2014-10
Does Duloxetine Reduce Chronic Pain After Total Knee Arthroplasty? NCT02307305	Unknown status	Phase 2	South Korea	Hanyang University Seoul Hospital	2014-08
Mechanistic Study of Duloxetine in Breast Cancer Patients With Chronic Pain NCT01912612	Completed	Phase 2	United States	University of Michigan Rogel Cancer Center	2013-10-30
An Open Label Extension Study of Duloxetine (LY248686) in Participants With Chronic Low Back Pain NCT01914666	Completed	Phase 3	Japan	Eli Lilly and Company	2013-09
A Study of Duloxetine in Participants With Chronic Pain Due to Osteoarthritis in China NCT01931475	Completed	Phase 3	China	Eli Lilly and Company	2013-09
A Study of Duloxetine (LY248686) in Participants With Chronic Low Back Pain NCT01855919	Completed	Phase 3	Japan	Eli Lilly and Company	2013-05
Duloxetine for the Treatment of Chronic Pelvic Pain NCT01451606	Terminated	Phase 4	United States	University of Maryland, Baltimore	2011-07-11
Comparison of the Efficacy of Duloxetine With Placebo in Patients With Chronic Low Back Pain With a Radicular Component NCT01166048	Completed	Phase 4	Austria	Medical University of Vienna	2010-05
Comparison of the Efficacy of Duloxetine With Placebo in Patients With Chronic Low Back Pain With a Radicular Component NCT01166048	Completed	Phase 4	Austria	Medical University of Vienna	2010-05
A Study for Patient With Chronic Low Back Pain NCT00767806	Completed	Phase 3	Brazil, Germany, Netherlands, Poland and 3 more	Eli Lilly and Company	2008-09
Three Way Interaction Between Gabapentin, Duloxetine, and Donepezil in Patients With Diabetic Neuropathy NCT00619983	Terminated	Phase 4	United States	Wake Forest University	2008-02
Duloxetine Treatment of Major Depression and Chronic Low Back Pain For Older Adults NCT00696293	Completed	Phase 4	United States	University of Pittsburgh	2007-05
Duloxetine Versus Placebo in Chronic Low Back Pain NCT00424593	Completed	Phase 3	Brazil, France, Germany, Mexico and 1 more	Eli Lilly and Company	2007-01
Open Label Study of Duloxetine for the Treatment of Phantom Limb Pain NCT00425230	Terminated	Not applicable	United States	Baylor College of Medicine	2007-01
Duloxetine Versus Placebo in Chronic Low Back Pain NCT00408876	Completed	Phase 3	United States	Eli Lilly and Company	2006-12
Imaging Study of Chronic Low Back Pain in Patients Taking Pain Medication NCT00388414	Completed	Not applicable	United States	Stanford University	2006-09

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.

Drug: duloxetine: chronic pain clinical trials

Trials in Canada

Trials worldwide (outside Canada)

Conditions studied with this intervention