GS-6615 in Adults With Chronic Stable Angina and Coronary Artery Disease

Inclusion Criteria: * Able to perform a standardized treadmill exercise protocol * At least a 3 month history of chronic stable angina triggered by physical effort and relieved by rest and/or short-acting nitroglycerin * Coronary artery disease (CAD) documented by one or more of the following: * Angiographic evidence (either invasive or noninvasive) of ≥ 50% stenosis of one or more major coronary arteries * History of myocardial infarction (MI) documented by positive creatine kinase-myocardial band (CK-MB) enzymes, troponins, or electrocardiogram (ECG) changes * Noninvasive imaging stress test diagnostic of CAD (eg, nuclear perfusion scan, stress echocardiogram, stress cardiac magnetic resonance scan) * Stable antianginal treatment with up to 2 antianginal agents Exclusion Criteria: * Inability to exercise or having exercise limitation due to other co-morbidities that may interfere with ability to perform required exercise tolerance testing (ETT) * Presence of electrocardiographic or other abnormalities that interfere with ECG interpretation or may cause a false positive stress test * History of heart failure as defined by New York Heart Association Class III-IV and/or known left ventricular ejection fraction ≤ 45% * History of severe disabling angina as defined by Canadian Cardiovascular Society Class IV * Myocardial infarction, acute coronary syndrome or coronary revascularization within 3 months prior to screening, or planned coronary revascularization during the study period * Stroke or transient ischemic attack within 6 months prior to screening * Chronic persistent atrial fibrillation * Uncontrolled hypertension (seated systolic blood pressure (SBP) \> 160 mm Hg or diastolic blood pressure (DBP) \> 110 mm Hg) * Body mass index (BMI) ≥ 36 kg/m\^2