Neurologic Signatures of Chronic Pain Disorders
CompletedPhase 4NCT02747940
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
"Brain signatures" as objective measures of acute pain have been characterized with functional magnetic resonance image and machine learning technology. As compared to acute pain, chronic pain leads to greater socioeconomic burden. However, measures for chronic pain remain subjective and suboptimal, and the brain signatures for chronic pain are largely unknown. Chronic migraine and fibromyalgia are two prototypes primary chronic pain disorders with high disability and intractability with prevalence of around 2% for both diseases. These two chronic pain disorders have shared clinical presentations (abnormal pain sensitivity, mood and sleep disorders), pathophysiology (central sensitization) and medical treatment (anti-depressants), despite different body parts are involved (head vs. whole body). The present integrated project aims to characterize both common and disease-specific brain signatures of chronic pain by investigating these two chronic pain disorders. Our findings may shed some light on the key mechanisms of pain chronification, and may pave the way for the optimization of diagnosis and prognostication, as well as formulation of personalized medicine in chronic pain, so as to improve life quality of these patients and to reduce socioeconomic loss. The present project includes three interdisciplinary sub-projects (plus one animal study, not listed here): A: Clinical studies for chronic migraine and fibromyalgia: endophenotypes and pain chronification B: Functional neuroimaging of chronic pain: multimodal quantitative analysis of brain connectomes C. Data stream mining technology for multimodal physiological signals of chronic pain: real-time tracking and clinical correlation The specific aims of the present projects include: 1. Identification of common and disease-specific brain signatures for chronic pain (sub-projects A, B, C) 2. Investigation of clinical indicators with predictive values by machine learning analysis of big data (sub-projects A, B, C) 3. E…
Study details
- Official title
- Neurologic Signatures of Chronic Pain Disorders
- Conditions
- Interventions
- Drug: flunarizine and/or pregabalin
- Sponsor
- Taipei Veterans General Hospital, Taiwan
- Collaborators
- Ministry of Science and Technology of the People´s Republic of China
- Start date
- 2015-12
- Primary completion
- 2019-12
- Sex
- All
- Age range
- from 20 Years to 70 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- Taiwan
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Control: devoid of any systemic or neurological diseases * Chronic migraine: by ICHD-III (International Classification of Headache Disorder) criteria * Fibromyalgia: by ACR (American College of Rheumatology) 2010 criteria Exclusion Criteria: * history of major systemic illness, including uncontrolled hypertension, diabetes, chronic renal insufficiency, autoimmune diseases or malignancies * history of neurological disorders which might affect sensation such as previous stroke or peripheral neuropathy * history of substance abuse (except painkillers) * heavy smokers (with a daily consumption \>20 cigarettes) * pregnancy or lactation * any contraindication for magnetic resonance imaging (MRI) * and any obvious infection or inflammation over a period of at least 1 month before the study.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT02747940