Chronic Migraine: clinical trials and information
Chronic Migraine clinical trials in Canada
| Phase | Provinces | ||||
|---|---|---|---|---|---|
| Pilot Study for a Machine Learning Test for Migraine NCT05517200 | Unknown status | Ontario | Headache Sciences Incorporated | 2022-09-03 | |
| Evaluation of Galcanezumab in the Prevention of Chronic Migraine NCT02614261 | Completed | Phase 3 | Eli Lilly and Company | 2015-11-30 |
Chronic Migraine clinical trials worldwide (outside Canada)
32 trials, 8 recruiting or not yet recruiting. Recruiting first.
| Phase | Countries | ||||
|---|---|---|---|---|---|
| Sequential, Multiple Assignment, Double Randomized Preference, Migraine Behavioral Trial NCT06170281 | Not yet recruiting | Not applicable | United States | Mayo Clinic | 2026-12 |
| Effects of Online Mindfulness Therapy on Pain and Stress in Adults With Chronic Migraine and Adverse Childhood Experiences NCT07033520 | Not yet recruiting | Not applicable | Colombia | Fundación Cardiovascular de Colombia | 2025-07-01 |
| Efficacy of Nerve Block Versus Botox in Chronic Migraine Management NCT06684249 | Recruiting | Not applicable | Egypt | Zagazig University | 2024-11-10 |
| Responding With Evidence and Access for Childhood Headaches NCT05889624 | Recruiting | Not applicable | United States | Children's Hospital Medical Center, Cincinnati | 2023-08-22 |
| Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA NCT05754190 | Recruiting | United States | Brown University | 2023-06-20 | |
| Gepant treAtments: EffectIveNess and tolERability (GAINER) NCT05903027 | Recruiting | Italy | University of Florence | 2023-06-15 | |
| Determining the Utility of a Behavioral Intervention in Chronic Migraine NCT05415020 | Recruiting | Not applicable | United States | Mayo Clinic | 2022-06-29 |
| Analysis of Headache Chronification With Imaging, Deep Phenotyping, and Proteomics NCT03231241 | Recruiting | United States | Stanford University | 2014-12-12 | |
| Italian Real-life obServational Study on the effecTiveness, sAfety and Tolerability of Atogepant in Migraine Patients NCT06414044 | Active, not recruiting | Italy | University of Florence | 2024-05-09 | |
| Effectiveness and Tolerability of Eptinezumab NCT06409845 | Completed | Italy | University of Florence | 2024-03-26 | |
| Ditan Acute tReatments: Effectiveness and Tolerability (DART) NCT05903040 | Completed | Italy | University of Florence | 2023-06-15 | |
| A Study of Remote Electrical Neuromodulation for Acute Procedural Pain NCT05730556 | Terminated | Not applicable | United States | Mayo Clinic | 2023-02-13 |
| A Study to Evaluate the Efficacy and Safety of TNX-1900 in Patients With Chronic Migraine NCT05679908 | Completed | Phase 2 | United States | Tonix Pharmaceuticals, Inc. | 2022-12-06 |
| The Effect of Different Exercise Types on Migraine Frequency in Individuals With Migraine NCT05568004 | Completed | Not applicable | Turkey (Türkiye) | Ege University | 2022-11-28 |
| Efficacy of GONB in Patients of Migraine NCT05679765 | Completed | Phase 4 | Pakistan | Pain Medicine Department | 2022-04-01 |
| Effectiveness of Multimodal Physical Therapy in Migraine NCT05226559 | Unknown status | Not applicable | Italy | Neuromed IRCCS | 2022-02-24 |
| Examination of Muscle Stiffness, Tenderness and Pressure Pain Thresholds During a Cycle of Botulinum Toxin A Treatment in Chronic Migraine Patients NCT05328687 | Completed | Denmark | Danish Headache Center | 2021-05-01 | |
| Mind Body Balance for Pediatric Migraine NCT04715685 | Active, not recruiting | Not applicable | United States | Children's Hospital Medical Center, Cincinnati | 2021-03-09 |
| Rate , Predictors and Outcome of Chronic Migraine NCT05079659 | Unknown status | Egypt | Assiut University | 2021-01-01 | |
| A Study of Galcanezumab (LY2951742) in Participants 12 to 17 Years of Age With Chronic Migraine NCT04616326 | Active, not recruiting | Phase 3 | Denmark, France, Germany, India and 7 more | Eli Lilly and Company | 2020-11-25 |
| miR-155 Expression in Episodic and Chronic Migraine NCT05891808 | Unknown status | Italy | IRCCS National Neurological Institute "C. Mondino" Foundation | 2020-09-22 | |
| Osteopathic Manipulative Treatment and Migraine Headaches NCT04976985 | Unknown status | Not applicable | United States | St. Luke's Hospital, Pennsylvania | 2018-10-02 |
| Treatment of Cervical Pain in Chronic Migraine NCT03453203 | Withdrawn | Not applicable | University Hospitals Cleveland Medical Center | 2018-04-29 | |
| Study to Evaluate the Efficacy of Intranasal Kinetic Oscillation Stimulation in the Preventive Treatment of Chronic Migraine NCT03400059 | Completed | Not applicable | Finland, Germany | Chordate Medical | 2018-03-22 |
| Neurologic Signatures of Chronic Pain Disorders NCT02747940 | Completed | Phase 4 | Taiwan | Taipei Veterans General Hospital, Taiwan | 2015-12 |
| Anesthetic Blockades and Migraine NCT02188394 | Completed | Phase 2 | Spain | César Fernández-de-las-Peñas | 2014-07 |
| Duration of Benefit for OnabotulinumtoxinA in Treatment of Chronic Migraine NCT02037425 | Completed | Phase 4 | United States | Cady, Roger, M.D. | 2014-04 |
| Assessment of LBR-101 In Chronic Migraine NCT02021773 | Completed | Phase 2 | United States | Teva Branded Pharmaceutical Products R&D, Inc. | 2014-01-31 |
| A Two-Arm Study Evaluation H.P. Acthar Injection Gel in Treatment of Chronic Migraines NCT01813591 | Completed | Phase 2 | United States | Dent Neuroscience Research Center | 2013-04 |
| Use of the Tx360 Nasal Applicator in the Treatment of Chronic Migraine NCT01709708 | Completed | Phase 4 | United States | Tian Medical Inc. | 2012-09 |
| Study Evaluated the Effectiveness of Milnacipran to Reduce Pain Levels in Individuals With Chronic Migraine NCT01393522 | Completed | Not applicable | United States | Timothy Smith | 2011-06 |
| OnabotulinumtoxinA Injections in Chronic Migraine, Targeted to Sites of Pericranial Myofascial Pain NCT03175263 | Completed | University Hospital, Limoges | 2008-09-01 |
About Chronic Migraine
What is Chronic Migraine?
Migraine is a neurological condition with recurring headaches that are often throbbing and may come with nausea and sensitivity to light or sound. Chronic migraine usually refers to headache on 15 or more days a month for more than three months, with migraine features on at least eight of those days.
How is Chronic Migraine usually assessed?
Diagnosis is usually based on the pattern of symptoms described in a history and a neurological examination. A headache diary is often used. Tests may be done to rule out other causes.
What kinds of treatments are studied for Chronic Migraine?
Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.
How can I find Chronic Migraine clinical trials in Canada?
This page lists 2 registry records for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.
Related conditions
Related interventions
Related US FDA drug labels
Labels whose indications text mentions this term. US labels, not Health Canada Product Monographs.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.