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Chronic Migraine: clinical trials and information

Migraine is a neurological condition with recurring headaches that are often throbbing and may come with nausea and sensitivity to light or sound. Chronic migraine usually refers to headache on 15 or more days a month for more than three months, with migraine features on at least eight of those days.
2
Trials with Canadian sites
0
Recruiting in Canada
34
Registry records worldwide

Chronic Migraine clinical trials in Canada

2 trials, recruiting first
PhaseProvinces
Pilot Study for a Machine Learning Test for Migraine
NCT05517200
Unknown statusOntarioHeadache Sciences Incorporated2022-09-03
Evaluation of Galcanezumab in the Prevention of Chronic Migraine
NCT02614261
CompletedPhase 3Eli Lilly and Company2015-11-30

Chronic Migraine clinical trials worldwide (outside Canada)

32 trials, 8 recruiting or not yet recruiting. Recruiting first.

PhaseCountries
Sequential, Multiple Assignment, Double Randomized Preference, Migraine Behavioral Trial
NCT06170281
Not yet recruitingNot applicableUnited StatesMayo Clinic2026-12
Effects of Online Mindfulness Therapy on Pain and Stress in Adults With Chronic Migraine and Adverse Childhood Experiences
NCT07033520
Not yet recruitingNot applicableColombiaFundación Cardiovascular de Colombia2025-07-01
Efficacy of Nerve Block Versus Botox in Chronic Migraine Management
NCT06684249
RecruitingNot applicableEgyptZagazig University2024-11-10
Responding With Evidence and Access for Childhood Headaches
NCT05889624
RecruitingNot applicableUnited StatesChildren's Hospital Medical Center, Cincinnati2023-08-22
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
NCT05754190
RecruitingUnited StatesBrown University2023-06-20
Gepant treAtments: EffectIveNess and tolERability (GAINER)
NCT05903027
RecruitingItalyUniversity of Florence2023-06-15
Determining the Utility of a Behavioral Intervention in Chronic Migraine
NCT05415020
RecruitingNot applicableUnited StatesMayo Clinic2022-06-29
Analysis of Headache Chronification With Imaging, Deep Phenotyping, and Proteomics
NCT03231241
RecruitingUnited StatesStanford University2014-12-12
Italian Real-life obServational Study on the effecTiveness, sAfety and Tolerability of Atogepant in Migraine Patients
NCT06414044
Active, not recruitingItalyUniversity of Florence2024-05-09
Effectiveness and Tolerability of Eptinezumab
NCT06409845
CompletedItalyUniversity of Florence2024-03-26
Ditan Acute tReatments: Effectiveness and Tolerability (DART)
NCT05903040
CompletedItalyUniversity of Florence2023-06-15
A Study of Remote Electrical Neuromodulation for Acute Procedural Pain
NCT05730556
TerminatedNot applicableUnited StatesMayo Clinic2023-02-13
A Study to Evaluate the Efficacy and Safety of TNX-1900 in Patients With Chronic Migraine
NCT05679908
CompletedPhase 2United StatesTonix Pharmaceuticals, Inc.2022-12-06
The Effect of Different Exercise Types on Migraine Frequency in Individuals With Migraine
NCT05568004
CompletedNot applicableTurkey (Türkiye)Ege University2022-11-28
Efficacy of GONB in Patients of Migraine
NCT05679765
CompletedPhase 4PakistanPain Medicine Department2022-04-01
Effectiveness of Multimodal Physical Therapy in Migraine
NCT05226559
Unknown statusNot applicableItalyNeuromed IRCCS2022-02-24
Examination of Muscle Stiffness, Tenderness and Pressure Pain Thresholds During a Cycle of Botulinum Toxin A Treatment in Chronic Migraine Patients
NCT05328687
CompletedDenmarkDanish Headache Center2021-05-01
Mind Body Balance for Pediatric Migraine
NCT04715685
Active, not recruitingNot applicableUnited StatesChildren's Hospital Medical Center, Cincinnati2021-03-09
Rate , Predictors and Outcome of Chronic Migraine
NCT05079659
Unknown statusEgyptAssiut University2021-01-01
A Study of Galcanezumab (LY2951742) in Participants 12 to 17 Years of Age With Chronic Migraine
NCT04616326
Active, not recruitingPhase 3Denmark, France, Germany, India and 7 moreEli Lilly and Company2020-11-25
miR-155 Expression in Episodic and Chronic Migraine
NCT05891808
Unknown statusItalyIRCCS National Neurological Institute "C. Mondino" Foundation2020-09-22
Osteopathic Manipulative Treatment and Migraine Headaches
NCT04976985
Unknown statusNot applicableUnited StatesSt. Luke's Hospital, Pennsylvania2018-10-02
Treatment of Cervical Pain in Chronic Migraine
NCT03453203
WithdrawnNot applicableUniversity Hospitals Cleveland Medical Center2018-04-29
Study to Evaluate the Efficacy of Intranasal Kinetic Oscillation Stimulation in the Preventive Treatment of Chronic Migraine
NCT03400059
CompletedNot applicableFinland, GermanyChordate Medical2018-03-22
Neurologic Signatures of Chronic Pain Disorders
NCT02747940
CompletedPhase 4TaiwanTaipei Veterans General Hospital, Taiwan2015-12
Anesthetic Blockades and Migraine
NCT02188394
CompletedPhase 2SpainCésar Fernández-de-las-Peñas2014-07
Duration of Benefit for OnabotulinumtoxinA in Treatment of Chronic Migraine
NCT02037425
CompletedPhase 4United StatesCady, Roger, M.D.2014-04
Assessment of LBR-101 In Chronic Migraine
NCT02021773
CompletedPhase 2United StatesTeva Branded Pharmaceutical Products R&D, Inc.2014-01-31
A Two-Arm Study Evaluation H.P. Acthar Injection Gel in Treatment of Chronic Migraines
NCT01813591
CompletedPhase 2United StatesDent Neuroscience Research Center2013-04
Use of the Tx360 Nasal Applicator in the Treatment of Chronic Migraine
NCT01709708
CompletedPhase 4United StatesTian Medical Inc.2012-09
Study Evaluated the Effectiveness of Milnacipran to Reduce Pain Levels in Individuals With Chronic Migraine
NCT01393522
CompletedNot applicableUnited StatesTimothy Smith2011-06
OnabotulinumtoxinA Injections in Chronic Migraine, Targeted to Sites of Pericranial Myofascial Pain
NCT03175263
CompletedUniversity Hospital, Limoges2008-09-01

About Chronic Migraine

What is Chronic Migraine?

Migraine is a neurological condition with recurring headaches that are often throbbing and may come with nausea and sensitivity to light or sound. Chronic migraine usually refers to headache on 15 or more days a month for more than three months, with migraine features on at least eight of those days.

How is Chronic Migraine usually assessed?

Diagnosis is usually based on the pattern of symptoms described in a history and a neurological examination. A headache diary is often used. Tests may be done to rule out other causes.

What kinds of treatments are studied for Chronic Migraine?

Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.

How can I find Chronic Migraine clinical trials in Canada?

This page lists 2 registry records for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.

Related conditions

Related interventions

Related US FDA drug labels

Labels whose indications text mentions this term. US labels, not Health Canada Product Monographs.

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.