Impact of Pregabalin in Chronic Users vs. a Perioperative Limited Prescription on Oxycodone Requirement
CompletedNCT02866396
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Spinal surgery is associated with intense pain and associated to a history of preoperative chronic pain. Pregabalin is licensed to treat chronic neuropathic pain, particularly when high dose of opioid are required. Preoperative pain is associated with high postoperative pain scores and opioid requirement promoting persistent hyperalgesic state. The investigators will evaluate the postoperative opioid consumption and pain scores in patients scheduled for lumbar surgery and taking pregabalin since more than 15 days and compare with preoperative pregabalin-free patient that will receive pregabalin only during surgery.
Study details
- Official title
- Postoperative Oxycodone Consumption After Spinal Surgery in Pregabalin-treated Patients Compared to a 48-h Perioperative Administration: a Prospective, Observational Study
- Conditions
- Interventions
- Drug: Pregabalin
- Other: Naive patient
- Sponsor
- Christophe Aveline, MD
- Collaborators
- Rennes University Hospital
- Organization
- Private Hospital Sevigne
- Start date
- 2016-09
- Primary completion
- 2017-09
- Sex
- All
- Age range
- from 18 Years to 85 Years
- Results posted
- No results posted in this snapshot
- Countries
- France
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * American Society Anesthesiologist Physical status (ASA) 1-3 * Age ≥18 years old * Spinal surgery: discectomy, posterior or transforaminal lumbar interbody fusion limited to 2 levels, lumbar disk prosthesis * Able to participate personality, has given free and inform consent in French * Affiliated of beneficiary of a system of social security Exclusion Criteria: * Age less than 18 years or higher than 85 years old * Refusal to participate or provide written consent * Surgery with a combined anterior and posterior approach * Emergency surgery, reintervention, spine fracture, metastasis * Tricyclic antidepressant use * Pregabalin use for other indication: other neuropathy, epilepsy, generalized anxiety disorder * Pregnancy * Lack of understanding of NRS and/or DN4 scores * Hypersensibility or contraindication to levobupivacaine, paracetamol, nefopam, ketoprofen and/or oxycodone * Participation in another clinical study
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT02866396