Repetitive Transcranial Magnetic Stimulation Associated With Manual Therapy in Knee Ostearthritis Pain
Unknown statusPhase 2NCT03076294
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
In this study, the investigators wondered whether the association between high frequency repetitive transcranial magnetic stimulation (hf-rTMS) and manual therapy (peripheral and central approach) is more effective in reducing pain levels and modulation of cortical activity of chronic knee ostearthritis pain subjects than manual therapy alone (usual peripheral approach). For this purpose, patients included will be submitted to one session with active or sham hf-rTMS followed by a protocol of manual therapy. Besides that another active group will have the sequence of interventions exchanged (manual therapy followed by hf-rTMS) in order to investigate whether this may influence in the final outcomes.
Study details
- Conditions
- Interventions
- Device: TMS
- Other: Manual therapy (MT)
- Sponsor
- Universidade Federal de Pernambuco
- Start date
- 2017-01
- Primary completion
- 2018-03
- Sex
- All
- Age range
- from 50 Years to 70 Years
- Results posted
- No results posted in this snapshot
- Countries
- Brazil
- Total sites listed
- 2
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Diagnosis of knee OA; * Absence of severe cognitive deficiency verified by the Mini Mental State Examination; * Meet the American College of Rheumatology criteria for idiopathic knee osteoarthritis. Exclusion Criteria: * Individuals diagnosed with osteoporosis, fibromyalgia or other neurological disease; * Had an opioid or corticosteroid injection in the last 30 days; * Modified chronic pain medication in the last month before participating in the study; * History of knee surgery in the last six months; * Obese; * Contraindications to the use of non-invasive brain stimulation, such as: metal implant on face or skull, history of seizure, cochlear implant.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT03076294