Changes in Affective Pain Processing in Human Volunteers
CompletedNot applicableNCT04280796
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The experience of pain is more than the conscious perception of nociceptive signals. Emotional and motivational aspects accompany pain, leading to its aversiveness and motivation for avoidance. In chronic pain, a negative hedonic shift has been proposed that is characterized by disproportionally increased emotional-motivational compared to sensory-discriminative pain responses. Such a negative hedonic shift is, for example, mirrored in very high comorbidity rates of chronic pain and affective disorders such as depression and anxiety. The aim of this study is to develop methods that allow the differentiation of sensory-discriminative and emotional-motivational pain response and to characterize mechanisms of the negative hedonic shift.
Study details
- Official title
- Mechanisms of Emotional-motivational Pain Processing in Health and Disease
- Conditions
- Interventions
- Behavioral: psychophysical tasks
- Behavioral: cognitive task
- Sponsor
- susanne becker
- Collaborators
- Swiss National Science Foundation
- Organization
- Balgrist University Hospital
- Start date
- 2020-09-21
- Primary completion
- 2023-11-01
- Sex
- All
- Age range
- from 18 Years to 60 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- Switzerland
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
For Healthy participants Inclusion Criteria: * good overall health status * sufficient knowledge of German or English to follow instructions * ability to give written informed consent Exclusion Criteria: * pain longer than \>3 consecutive days and on more than 30 days within the last 12 months * major psychiatric or neurological disorders, and substance abuse * consumption of alcohol, illegal drugs, and analgesic drug within 24 hours before testing For chronic pain patients Inclusion Criteria: * unspecific musculoskeletal chronic pain * sufficient knowledge of German or English to follow instructions * ability to give written informed consent Exclusion Criteria: * major psychiatric or neurological disorders, excluding depression and anxiety, and substance abuse * consumption of alcohol, illegal drugs, and analgesic drugs within 24 hours before testing
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT04280796