Postoperative Painful Chronicization After Knee Replacement Surgery : Exploratory Study of BDNF's Kinetics
CompletedNot applicableNCT04604847
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Chronic pain is an extremely disabling disease. It is a major public health problem due to the lack of effective therapy. Chronic postoperative pain (CPOP) is defined by a painful symptomatology in the operated area unrelated to previous pain, present for more than 3 months, and without any link to surgical complication. The prevalence of chronicization of postoperative pain is 30% after total knee arthroplasty. Identification of clinical, biological and psychological profiles are crucial to prevent CPOP. A biologic factor, Brain Derived Neurotrophic Factor (BDNF) produced by a variety of cells is a key regulator of neuroplasticity. BDNF is increasingly studied in the mechanisms of cerebral sensitization and pain chronicization. The role of BDNF in pain of patients remains to be explored in a prospective study. The aim of this observational study is to compare the kinetics of BDNF after total knee arthroplasty in patients with and without CPOP. Patients will be included in the study at the preanesthetic consultation. Serum BDNF levels will be measured preoperatively, 48h postoperatively, 3 and 6 months after surgery.
Study details
- Official title
- Postoperative Painful Chronicization After Knee Replacement Surgery : Exploratory Study of BDNF's Kinetics
- Conditions
- Total Knee Arthroplasty
- Chronic Postoperative Pain
- Interventions
- Diagnostic test: blood test
- Sponsor
- University Hospital, Montpellier
- Collaborators
- Institut National de la Santé Et de la Recherche Médicale, France
- Start date
- 2020-12-04
- Primary completion
- 2024-03-19
- Sex
- All
- Age range
- from 18 Years
- Results posted
- No results posted in this snapshot
- Countries
- France
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Social security affiliation * Adult patients * Signed informed consent * Score ASA (American Society of Anesthesiology) 1-3 * Total knee arthroplasty Exclusion Criteria: * Patient unable to exercise consent * Pregnant women * Vulnerable people * Patients not included in the postoperative rehabilitation program * Patients unable to complete the pain assessment questionnaires * Chronic pain patients (other than knee arthrosis) * Neuropathic pain patients (beforehand) * Inflammatory diseases, progressive cancer, sepsis, immunosuppression known
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT04604847