Effectiveness of Blood Flow Restriction Exercise Therapy to Reduce Pain in Knee Osteoarthritis Patients
Unknown statusNot applicableNCT04917952
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Resistance training of knee extensor muscles is being used in physiotherapy management in knee osteoarthritis (OA) to improve pain and physical function. Blood flow restriction (BFR) has been suggested to improve pain and increase muscle strength in healthy subjects and certain diseases. Although there are clinical studies suggesting improvements in knee osteoarthritis symptoms after 4-12 weeks of exercise with BFR, the acute effects of the intervention have not been known. This study aims to assess the effectiveness of low load exercise therapy combined with BFR on acute pain reduction and within 24 hours post-intervention on people with knee OA compared to a placebo group. This study will take place in Athens, Greece, as part of the postgraduate MSc program of the Physiotherapy department of the University of West Attica.
Study details
- Official title
- Effectiveness of Blood Flow Restriction (BFR) Exercise Therapy to Reduce Pain in Knee Osteoarthritis (OA) Patients. A Double-blinded Randomised Clinical Trial
- Conditions
- Interventions
- Device: Blood Flow Restriction (BFR)
- Device: Sham Blood Flow Restriction (sham BFR)
- Sponsor
- University of West Attica
- Start date
- 2021-06
- Primary completion
- 2021-08
- Sex
- All
- Results posted
- No results posted in this snapshot
- Total sites listed
- 0
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Current osteoarthritis clinical diagnosis according to either European League Against Rheumatism (EULAR) or American College of Rheumatology (ACR) criteria * VAS/NRS Knee pain ≥3/10 during activity Exclusion Criteria: * Previous experience with BFR * Has followed knee exercise or kinesiotherapy program in the past 3 months * New medicines in the past 3 months * Any lower limb surgery in the past 6 months * Knee arthroplasty surgery (Knee replacement) * Any active healing process affecting walking (fracture, sprain, strain, etc.) * Diagnosed with rheumatologic/neurologic disease affecting functionality * Diagnosed or history of heart or vascular diseases * Diagnosed with respiratory/metabolic disease * Personal history of cancer * Cognitive problems * Pregnancy (only for female participants) * Any other indication not to participate in exercise
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT04917952