Reconsolidation Therapy With Propranolol as a Treatment for Chronic Pain
CompletedPhase 2NCT05085782
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Brief summary (from the registry)
The primary aim of this study is to document the feasibility and acceptability of an intervention consisting of pain neuroscience education and reconsolidation therapy with propranolol in adults suffering from chronic pain (chronic low back pain or fibromyalgia). The secondary aim of the study is to estimate the effect size of the intervention on pain and function one month post-intervention, and to obtain data for sample-size calculation for a subsequent randomized controlled trial.
Study details
- Official title
- Reconsolidation Therapy With Propranolol as a Novel Treatment for Chronic Pain : a Placebo-controlled Feasibility Study
- Conditions
- Interventions
- Drug: Propranolol Hydrochloride
- Drug: Placebo
- Behavioral: Reactivation procedure
- Behavioral: Pain neuroscience education
- Sponsor
- Université de Sherbrooke
- Start date
- 2022-02-07
- Primary completion
- 2024-12-30
- Sex
- All
- Age range
- from 18 Years to 65 Years
- Results posted
- No results posted in this snapshot
- Countries
- Canada
- Total sites listed
- 2
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * French speaking * Suffering from \[chronic low back pain OR fibromyalgia\] for \>6 months * Average pain at least 4/10 * Central sensitization (assessed via a standardized physiotherapy evaluation and the Central Sensitization Inventory) Exclusion Criteria: * Health condition for which propranolol is contra-indicated * Medication with which co-administration of propranolol is contra-indicated * Severe or uncontrolled neurological/psychiatric condition (including post-traumatic stress disorder, substance abuse, suicidal ideation, etc.) * Surgery of the lower-back in the last 3 years * Litigation surrounding the painful condition
Canadian sites (2)
| Facility | City | Province |
|---|---|---|
| CRCHUS: Centre de recherche du centre hospitalier universitaire de Sherbrooke | Sherbrooke | Quebec |
| Centre de recherche sur le vieillissement (CdRV) | Sherbrooke | Quebec |
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT05085782