Donepezil for Oxaliplatin-induced Neuropathy Peripheral Neuropathy: Proof of Concept Study
CompletedPhase 2NCT05254639
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The use of oxaliplatin in the treatment of colorectal or pancreas cancer induces (\>75% of patients) severe sensorimotor neuropathy decreasing the quality of life of cancer survivors. Today, no treatment remains univocal for these peripheral neuropathies. But preclinical works have demonstrated that donepezil (acetylcholinesterase inhibitor use for Alzheimer's disease) was able to prevent and treat neuropathic symptoms in oxaliplatin-treated rats. Present study aims to assess the therapeutic efficacy of donepezil on oxaliplatin-induced peripheral neuropathy (OIPN) in cancer survivors. Bibliographic data suggests an antineuropathic effect of donepezil in human and animal models. In clinic, a study have shown in healthy volunteers that donepezil (associated with gabapentin) reduced the pain threshold (better than gabapentin alone) caused by stimulation of the sural nerve, without severe adverse effect. Similarly, two studies in patients with neuropathic pain demonstrated that donepezil increases analgesic effect of gabapentin. Finally, a case report demonstrated an analgesic effect of donepezil in painful Alzheimer's disease patients. In animals, several studies demonstrated that donepezil induces analgesic and neuroprotective effects. Recently, a preclinical study demonstrated that donepezil induced antineuropathic effect in diabetic mice with neuropathic pain. Research unit INSERM U1107 (partner of the DONEPEZOX study) demonstrated the antineuropathic effects of donepezil in several animal models of chemotherapy-induced peripheral neuropathies, and very recently, a study have confirmed these results with oxaliplatin and cisplatin. These clinical and preclinical data have thus highlighted the potential beneficial effect of donepezil on neuropathic symptoms, without any significant adverse effects. Therefore the hypothesis is that the use of donepezil could reduce the symptoms of OIPN, limit the decrease in quality of life and the appearance of comorbidities (anxiety/…
Study details
- Official title
- Evaluation of the Efficacy of Donepezil in the Treatment of Oxaliplatin-induced Peripheral Neuropathy: Proof of Concept Study
- Conditions
- Digestive Oncology
- Supportive Care
- Interventions
- Drug: DONEPEZIL
- Drug: PLACEBO
- Sponsor
- University Hospital, Clermont-Ferrand
- Collaborators
- Federation Francophone de Cancerologie Digestive
- Start date
- 2022-06-02
- Primary completion
- 2024-01-24
- Sex
- All
- Age range
- from 18 Years
- Results posted
- No results posted in this snapshot
- Countries
- France
- Total sites listed
- 34
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Patient who received chemotherapy with oxaliplatin for all stage of colorectal or pancreas cancer, * QLQ-CIPN20 sensory score ≥30, * Diagnosis of chemotherapy-induced peripheral neuropathy treated or not by stable antineuropathic/analgesic treatment (opioids, pregabalin, gabapentin, duloxetine and other antidepressants or anticonvulsants) for at least 1 month, * Chemotherapy completed for at least 6 months, * Patients affiliated to the French national health insurance, * Written informed consent, * French language comprehension. Exclusion Criteria: * Cancer relapse or secondary cancer, * Lack of effective contraception in patients (female) of childbearing age, pregnant or breastfeeding women, women of childbearing age who have not taken a pregnancy test, * Patient with a chronic progressive disease with associated chronic pain (excluding oxaliplatin-induced peripheral neuropathy), * Diabetic patient (excluding non-insulin- or insulin-treated diabetes less than 5 years old) or presence of proven diabetic neuropathy, * Other types of neuropathies, * ALT / AST elevated more than 3 times the normal values, * Severe cardiovascular disease (as determined by clinician), bradycardia (\< 55 bpm), cardiac conduction disorders such as sinus disease or other supraventricular conduction abnormalities such as sino-auricular or atrioventricular block (assessed by electrocardiogram), * History of peptic ulcer disease or active peptic ulcer disease, * Asthma or chronic obstructive pulmonary disease, * Known allergy to donepezil or piperidine derivatives, * Known galactose intolerance, known Lapp lactase deficiency or known glucose or galactose malabsorption syndrome (rare hereditary diseases), * Drug interactions: CYP3A4 inhibitors (ketoconazole, itraconazole and erythromycin); CYP2D6 inhibitors (fluoxetine, quinidine) and enzymatic inducers (rifampicin, phenytoin, carbamazepine), * Known dependence on alcohol and/or drugs, * Known psychotic disorders, patient under antipsychotics, * Planned surgery during the trial, * Impossible to undergo the medical follow-up of the trial for geographical, social or psychological reasons, * Person under guardianship, curatorship, safeguard of justice or person deprived of liberty.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT05254639