Management of Knee Pain by Cooled Radiofrequency in Classical Anatomical Targets and Revised Targets
CompletedNot applicableNCT05363241
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Osteoarthritis (OA) is a chronic and progressive disease that results from characteristic pathological changes in the tissues of the entire joint, resulting in failure in the component parts. OA is one of the most common causes of disability in adults due to pain and altered joint function, impacting patients' quality of life. Treatment is based on decreasing pain and improving function, involving non-pharmacological, pharmacological, and surgical management. First-line treatment involves non-pharmacological and pharmacological measures. When OA is very advanced, total joint replacement surgery is recommended. However, for patients refractory to conservative treatment and unwilling or unable to undergo arthroplasty, few options remain. Recently, several studies involving minimally invasive procedures are being recommended. Among them is the cooled radiofrequency technique, causing neurotomy by thermal activity, thus reducing the patient's perception of pain. The classical therapeutic target for this technique are the genicular nerves of the knee. However, more recent studies have shown that these classical targets do not provide complete pain relief and have suggested new therapeutic targets, comprising besides the genicular nerves, the recurrent peroneal nerve and the infra-patellar branch of the saphenous nerve. In order to validate these revised targets, new studies need to be done. Therefore, the aim of the present study is to evaluate the efficacy of the cooled radiofrequency procedure using classical and revised targets, and to compare pain intensity, knee function, quality of life, analgesic consumption and adverse effects of both techniques. Key words: Osteoarthritis of the knee. Sensory nerve denervation. Classical targets. Revised targets.
Study details
- Official title
- Comparison of Genicular Nerve Denervation by Cooled Radiofrequency Using Classical and Revised Anatomical Targets for Pain Management of Osteoarthritis of the Knee Osteoarthritis: Clinical Study
- Interventions
- Procedure: Cooled radiofrequency in classical targets (CRF-CT)
- Procedure: Cooled radiofrequency in revised targets (CRF-RT)
- Sponsor
- Universidade Federal de Alfenas
- Collaborators
- SINPAIN LTDA
- Start date
- 2022-09-01
- Primary completion
- 2024-05-31
- Sex
- All
- Age range
- from 40 Years
- Results posted
- No results posted in this snapshot
- Countries
- Brazil
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Patients of both genders aged 40 years or older; * Patients diagnosed with knee OA through X-rays and MRI (Alhback classification 2 or 3); * Patients with chronic knee pain for more than 3 months at the time of inclusion; * Patients with moderate to severe knee pain (score of 5 or more on the visual analog scale) * Patients who are literate, can read and write, and have a good understanding of written and verbal language. Exclusion Criteria: * Patients younger than 40 years old, even if diagnosed with knee OA; * Patients not diagnosed through imaging tests with OA; * Patients who have undergone previous knee surgery in the last 3 months before inclusion; * Patients who have received intra-articular corticosteroid injection in the last 3 months before inclusion; * Patients with uncontrolled neurological or psychiatric disease; * Patients with uncontrolled diabetes; * Pregnant patients; * Cancer diagnosed patients; * Patients with lumbar radiculopathy; * Patients on continuous anticoagulant therapy; * Patients who are not literate, can not read and write, and have not a good understanding of written and verbal language.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT05363241