| Standard Versus Novel RFA for Chronic Knee Pain in Osteoarthritis NCT07674082 | Not yet recruiting | Not applicable | | Lawson Research Institute of St. Joseph's | 2026-07-20 |
| A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain NCT07641517 | Recruiting | Phase 2 | Puerto Rico, United States | Eli Lilly and Company | 2026-06-25 |
| Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty NCT06083480 | Recruiting | Phase 4 | United States | Vanderbilt University Medical Center | 2024-12-06 |
| Embo Registry; National Registry for Artery Embolization NCT06477965 | Recruiting | | United States | Vascular Solutions of North Carolina | 2024-07-15 |
| Effects of Including a Chronic Pain Neuroscience Education Program for Individuals With Knee OA NCT06187038 | Recruiting | Not applicable | Brazil | University of Nove de Julho | 2024-05-28 |
| Helping Osteoarthritis Patients to Walk With NSAID NCT05761015 | Recruiting | Phase 4 | France | University Hospital, Clermont-Ferrand | 2023-12-14 |
| Finding the Optimal Aim of Correction in Opening Wedge High Tibial Osteotomy NCT06134050 | Not yet recruiting | Not applicable | | Vestre Viken Hospital Trust | 2023-11 |
| Perfusion MRI-targeted Joint Embolization for Chronic Musculoskeletal Pain of the Shoulder, Hip and Knee NCT05700682 | Recruiting | | United States | Palo Alto Veterans Institute for Research | 2023-07-15 |
| Prospective Functional, Gait, and Outcome Comparison Study of Medial Pivot Versus Single Radius Design for Total Knee Arthroplasty NCT04814082 | Recruiting | Not applicable | United States | LifeBridge Health | 2021-02-01 |
| A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain NCT05986292 | Recruiting | Phase 2 | Puerto Rico, United States | Eli Lilly and Company | 2020-01-30 |
| Impact of Dexamethasone Route on Pain and Inflammation in iPACK With ACB for Knee Arthroplasty NCT07180953 | Completed | Phase 4 | Poland | Poznan University of Medical Sciences | 2025-09-13 |
| Positive Minds Strong Joints for Knee Osteoarthritis NCT06493903 | Active, not recruiting | Not applicable | United States | Boston University Charles River Campus | 2025-02-17 |
| Comparison Between Ultrasound-Guided Genicular Nerve Phenol Neurolysis and Intra-articular Steroid Injections NCT06000709 | Unknown status | Phase 4 | | University of Manitoba | 2023-10-20 |
| Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty) NCT05787821 | Active, not recruiting | | United States | Zimmer Biomet | 2023-06-28 |
| Comparing Pain Outcomes of Treatment Strategies for Osteoarthritis Knee Patients NCT05700253 | Unknown status | Not applicable | Singapore | Changi General Hospital | 2023-02 |
| Study of StimRouter for Chronic Knee OA Pain NCT05644639 | Completed | | United States | Bioventus LLC | 2022-10-18 |
| Understanding Pain Mechanisms in Knee Osteoarthritis NCT05561010 | Unknown status | Not applicable | | Nottingham University Hospitals NHS Trust | 2022-10 |
| Management of Knee Pain by Cooled Radiofrequency in Classical Anatomical Targets and Revised Targets NCT05363241 | Completed | Not applicable | Brazil | Universidade Federal de Alfenas | 2022-09-01 |
| A Study of the Feasibility of Using the Dietary Supplement "ARTNEO" in Patients With Osteoathritis NCT05975879 | Completed | Not applicable | Russia | NPO Petrovax | 2022-05-31 |
| Intra-articular Pulsed Radiofrequency in Chronic Knee Pain NCT06017674 | Completed | Not applicable | Turkey (Türkiye) | Başakşehir Çam & Sakura City Hospital | 2022-05-01 |
| A Telehealth Study of a Wearable Electroceutical & Sports Sleeve for Knee Osteoarthritis Pain Relief & Improved Function NCT04938271 | Unknown status | Not applicable | Israel | Healables Ltd. | 2021-11-22 |
| Study to Evaluate Intra-articular Resiniferatoxin to Treat Moderate to Severe Pain From Knee Osteoarthritis NCT04885972 | Unknown status | Phase 2 | United States | Sorrento Therapeutics, Inc. | 2021-11-15 |
| Phenol Neurolysis of Genicular Nerves for Osteoarthritic Knee Pain NCT04989660 | Unknown status | Phase 4 | United States | Kessler Foundation | 2021-11-01 |
| Predictive Values for the Outcome of Genicular Nerve Radiofrequency Ablation for Chronic Knee Pain NCT05222776 | Completed | | Turkey (Türkiye) | Diskapi Teaching and Research Hospital | 2021-11-01 |
| Study to Evaluate Resiniferatoxin in Patients With Knee Osteoarthritis Whose Total Knee Replacement Surgery is Delayed NCT04386980 | Withdrawn | Phase 3 | | Sorrento Therapeutics, Inc. | 2021-04 |
| A Phase 3 Study to Evaluate the Efficacy and Safety of Resiniferatoxin for Pain Due to Osteoarthritis of the Knee NCT04044742 | Withdrawn | Phase 3 | | Sorrento Therapeutics, Inc. | 2020-12 |
| Generate and Test the Reliability of a PD Model of OXT on Pupillary Hippus as a Measure of CNS Activity NCT04427709 | Terminated | Phase 2 | United States | Wake Forest University Health Sciences | 2020-11-30 |
| ROMTECH PortableConnect Rehabilitation Device Usage Post Unilateral Total Knee Arthroplasty (TKA) NCT04497129 | Completed | Not applicable | United States | ROM Technologies, INC | 2020-08-17 |
| Effectiveness of Acupuncture Clinical Pathway NCT04490798 | Completed | | Spain | Hospital Son Llatzer | 2020-06-12 |
| Pulsed Radiofrequency and Osteoarthritic Chronic Knee Pain NCT04454710 | Completed | Not applicable | Italy | University of Rome Tor Vergata | 2020-01-01 |
| Effectiveness of a Walking Intervention on Impact Loading and Pain NCT04148807 | Unknown status | Not applicable | United States | Northeastern University | 2019-11-05 |
| Duloxetine Combined With Intra-articular Injection of Corticosteroid and Hyaluronic Acid Reduces Pain in the Treatment of Knee Osteoarthritis Patients NCT04117893 | Completed | Phase 4 | China | Beijing Tiantan Hospital | 2019-10-01 |
| A Novel Smartphone Application for "Smart" Knee Osteoarthritis Trials NCT04051489 | Completed | | Brazil | Universidade Federal de Sao Carlos | 2019-09-03 |
| Cryoneurolysis for the Management of Chronic Pain in Patients With Knee Osteoarthritis NCT03774121 | Completed | Not applicable | Denmark | Esbjerg Hospital - University Hospital of Southern Denmark | 2019-06-26 |
| Chronic Pain, Couples, & Physical Activity NCT04077164 | Terminated | | United States | Illinois Institute of Technology | 2019-04-09 |
| A Prospective Multicenter Longitudinal Cohort Study of the Mymobility Platform NCT03737149 | Completed | Not applicable | Australia, Italy, Netherlands, United States | Zimmer Biomet | 2018-10-22 |
| A Clinical Study to Test Efficacy and Safety of Repeat Doses of CNTX-4975-05 in Patients With Osteoarthritis Knee Pain NCT03660943 | Completed | Phase 3 | United States | Centrexion Therapeutics | 2018-09-09 |
| Ultrasound-guided Genicular Nerve Block With Phenol for the Treatment of Chronic Pain Due to Knee Osteoarthritis NCT03601533 | Unknown status | Not applicable | Brazil | Federal University of São Paulo | 2018-06-05 |
| Effects of tDCS in Elderly With Pain Due to Knee Osteoarthritis NCT03117231 | Completed | Not applicable | Brazil | Federal University of São Paulo | 2018-03-15 |
| A Phase 3 Efficacy and Safety Study of Intra-articular CNTX-4975-05 (Capsaicin) vs Placebo in Subjects With OA Knee Pain NCT03429049 | Completed | Phase 3 | United States | Centrexion Therapeutics | 2018-01-24 |
| Effects of Action Observation Therapy on Pain, Functional Level and Brain Hemodynamic in Patients With Knee Osteoarthritis NCT03245073 | Completed | Not applicable | Turkey (Türkiye) | Acibadem University | 2017-09-15 |
| AP-003-C Study to Confirm the Efficacy of Ampion™ in Adults With Pain Due to Severe Osteoarthritis of the Knee NCT03182686 | Completed | Phase 3 | United States | Ampio Pharmaceuticals. Inc. | 2017-06-19 |
| Radiofrequency For Chronic Knee Pain Post-Arthroplasty NCT02931435 | Completed | Not applicable | United States | Randall Brewer, MD, CPI | 2016-12 |
| Saphenous Nerve Radiofrequency for Knee Osteoarthritis Trial NCT02826850 | Unknown status | Phase 3 | Brazil | University of Sao Paulo General Hospital | 2016-09 |
| Intra-articular Lopain (MTX-071) Phase I/IIa Study in Chronic Osteoarthritic Knee Joint Pain NCT02566564 | Completed | Phase 1 | Belgium | Grünenthal GmbH | 2016-04 |
| Diagnostic Genicular Nerve Block Prior to Radiofrequency Ablation for Knee Osteoarthritis Pain NCT02578108 | Completed | Not applicable | United States | Northwestern University | 2015-10 |
| Long Term Safety and Efficacy Study of Tanezumab in Subjects With Osteoarthritis of the Hip or Knee NCT02528188 | Completed | Phase 3 | Australia, Brazil, Bulgaria, Colombia and 14 more | Pfizer | 2015-07-21 |
| Retrospective Study of the Results of Cooled Radiofrequency for Genicular Nerves Neurotomy in 40 Consecutive Patients With Osteoarthritis of the Knee and Painful Knee Arthroplasty NCT03343808 | Completed | | | Hospital Son Espases | 2015-01-08 |
| Efficacy of Cooled and Monopolar Radiofrequency Ablation of the Geniculate Nerves for the Treatment of Chronic Osteoarthritic Knee Pain NCT02260869 | Terminated | Not applicable | United States | Millennium Pain Center | 2015-01 |
| Effect of Cranial Stimulation and Acupuncture on Pain, Functional Capability and Cerebral Function in Osteoarthritis NCT01747070 | Completed | Not applicable | Brazil | Hospital de Clinicas de Porto Alegre | 2014-03 |