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Osteoarthritis, Knee: clinical trials and information

Osteoarthritis is the most common form of arthritis. It involves breakdown of cartilage and changes in the bone and tissues of a joint, most often in the knees, hips, hands and spine, and can cause pain, stiffness and reduced movement.
6
Trials with Canadian sites
0
Recruiting in Canada
66
Registry records worldwide

Osteoarthritis, Knee clinical trials in Canada

6 trials, recruiting first
PhaseProvinces
3-point vs 6-point GNRFA for Chronic KOA
NCT05930756
WithdrawnNot applicableOntarioMcMaster University2025-08-09
Subchondroplasty® Knee RCT
NCT03112200
CompletedNot applicableOntarioZimmer Biomet2017-03-29
A Safety and Tolerability Study of JNJ-42160443 in Patients With Moderate to Severe, Chronic Knee Pain From Osteoarthritis
NCT01094262
TerminatedPhase 2Ontario, QuebecJohnson & Johnson Pharmaceutical Research & Development, L.L.C.2010-04-20
A Dose-ranging Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Osteoarthritis-related Pain
NCT00973141
TerminatedPhase 2British Columbia, Newfoundland and Labrador, Ontario, QuebecJohnson & Johnson Pharmaceutical Research & Development, L.L.C.2009-09-16
A Study to Evaluate Long-Term Safety of Multiple Doses of Tapentadol (CG5503) Prolonged-Release (PR) and Oxycodone Controlled-Release (CR) in Patients With Chronic Pain
NCT00361504
CompletedPhase 3Alberta, British Columbia, Nova Scotia, Ontario, Quebec, SaskatchewanJohnson & Johnson Pharmaceutical Research & Development, L.L.C.2006-11
Study Of "Continuous Use" Of Celecoxib Vs. "Usual or Intermittent Use"
NCT00139776
CompletedPhase 4Alberta, British Columbia, Newfoundland and Labrador, Ontario, Prince Edward Island, Quebec, SaskatchewanPfizer's Upjohn has merged with Mylan to form Viatris Inc.2005-07

Osteoarthritis, Knee clinical trials worldwide (outside Canada)

60 trials, 10 recruiting or not yet recruiting. Recruiting first.

PhaseCountries
Standard Versus Novel RFA for Chronic Knee Pain in Osteoarthritis
NCT07674082
Not yet recruitingNot applicableLawson Research Institute of St. Joseph's2026-07-20
A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain
NCT07641517
RecruitingPhase 2Puerto Rico, United StatesEli Lilly and Company2026-06-25
Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty
NCT06083480
RecruitingPhase 4United StatesVanderbilt University Medical Center2024-12-06
Embo Registry; National Registry for Artery Embolization
NCT06477965
RecruitingUnited StatesVascular Solutions of North Carolina2024-07-15
Effects of Including a Chronic Pain Neuroscience Education Program for Individuals With Knee OA
NCT06187038
RecruitingNot applicableBrazilUniversity of Nove de Julho2024-05-28
Helping Osteoarthritis Patients to Walk With NSAID
NCT05761015
RecruitingPhase 4FranceUniversity Hospital, Clermont-Ferrand2023-12-14
Finding the Optimal Aim of Correction in Opening Wedge High Tibial Osteotomy
NCT06134050
Not yet recruitingNot applicableVestre Viken Hospital Trust2023-11
Perfusion MRI-targeted Joint Embolization for Chronic Musculoskeletal Pain of the Shoulder, Hip and Knee
NCT05700682
RecruitingUnited StatesPalo Alto Veterans Institute for Research2023-07-15
Prospective Functional, Gait, and Outcome Comparison Study of Medial Pivot Versus Single Radius Design for Total Knee Arthroplasty
NCT04814082
RecruitingNot applicableUnited StatesLifeBridge Health2021-02-01
A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
NCT05986292
RecruitingPhase 2Puerto Rico, United StatesEli Lilly and Company2020-01-30
Impact of Dexamethasone Route on Pain and Inflammation in iPACK With ACB for Knee Arthroplasty
NCT07180953
CompletedPhase 4PolandPoznan University of Medical Sciences2025-09-13
Positive Minds Strong Joints for Knee Osteoarthritis
NCT06493903
Active, not recruitingNot applicableUnited StatesBoston University Charles River Campus2025-02-17
Comparison Between Ultrasound-Guided Genicular Nerve Phenol Neurolysis and Intra-articular Steroid Injections
NCT06000709
Unknown statusPhase 4University of Manitoba2023-10-20
Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)
NCT05787821
Active, not recruitingUnited StatesZimmer Biomet2023-06-28
Comparing Pain Outcomes of Treatment Strategies for Osteoarthritis Knee Patients
NCT05700253
Unknown statusNot applicableSingaporeChangi General Hospital2023-02
Study of StimRouter for Chronic Knee OA Pain
NCT05644639
CompletedUnited StatesBioventus LLC2022-10-18
Understanding Pain Mechanisms in Knee Osteoarthritis
NCT05561010
Unknown statusNot applicableNottingham University Hospitals NHS Trust2022-10
Management of Knee Pain by Cooled Radiofrequency in Classical Anatomical Targets and Revised Targets
NCT05363241
CompletedNot applicableBrazilUniversidade Federal de Alfenas2022-09-01
A Study of the Feasibility of Using the Dietary Supplement "ARTNEO" in Patients With Osteoathritis
NCT05975879
CompletedNot applicableRussiaNPO Petrovax2022-05-31
Intra-articular Pulsed Radiofrequency in Chronic Knee Pain
NCT06017674
CompletedNot applicableTurkey (Türkiye)Başakşehir Çam & Sakura City Hospital2022-05-01
A Telehealth Study of a Wearable Electroceutical & Sports Sleeve for Knee Osteoarthritis Pain Relief & Improved Function
NCT04938271
Unknown statusNot applicableIsraelHealables Ltd.2021-11-22
Study to Evaluate Intra-articular Resiniferatoxin to Treat Moderate to Severe Pain From Knee Osteoarthritis
NCT04885972
Unknown statusPhase 2United StatesSorrento Therapeutics, Inc.2021-11-15
Phenol Neurolysis of Genicular Nerves for Osteoarthritic Knee Pain
NCT04989660
Unknown statusPhase 4United StatesKessler Foundation2021-11-01
Predictive Values for the Outcome of Genicular Nerve Radiofrequency Ablation for Chronic Knee Pain
NCT05222776
CompletedTurkey (Türkiye)Diskapi Teaching and Research Hospital2021-11-01
Study to Evaluate Resiniferatoxin in Patients With Knee Osteoarthritis Whose Total Knee Replacement Surgery is Delayed
NCT04386980
WithdrawnPhase 3Sorrento Therapeutics, Inc.2021-04
A Phase 3 Study to Evaluate the Efficacy and Safety of Resiniferatoxin for Pain Due to Osteoarthritis of the Knee
NCT04044742
WithdrawnPhase 3Sorrento Therapeutics, Inc.2020-12
Generate and Test the Reliability of a PD Model of OXT on Pupillary Hippus as a Measure of CNS Activity
NCT04427709
TerminatedPhase 2United StatesWake Forest University Health Sciences2020-11-30
ROMTECH PortableConnect Rehabilitation Device Usage Post Unilateral Total Knee Arthroplasty (TKA)
NCT04497129
CompletedNot applicableUnited StatesROM Technologies, INC2020-08-17
Effectiveness of Acupuncture Clinical Pathway
NCT04490798
CompletedSpainHospital Son Llatzer2020-06-12
Pulsed Radiofrequency and Osteoarthritic Chronic Knee Pain
NCT04454710
CompletedNot applicableItalyUniversity of Rome Tor Vergata2020-01-01
Effectiveness of a Walking Intervention on Impact Loading and Pain
NCT04148807
Unknown statusNot applicableUnited StatesNortheastern University2019-11-05
Duloxetine Combined With Intra-articular Injection of Corticosteroid and Hyaluronic Acid Reduces Pain in the Treatment of Knee Osteoarthritis Patients
NCT04117893
CompletedPhase 4ChinaBeijing Tiantan Hospital2019-10-01
A Novel Smartphone Application for "Smart" Knee Osteoarthritis Trials
NCT04051489
CompletedBrazilUniversidade Federal de Sao Carlos2019-09-03
Cryoneurolysis for the Management of Chronic Pain in Patients With Knee Osteoarthritis
NCT03774121
CompletedNot applicableDenmarkEsbjerg Hospital - University Hospital of Southern Denmark2019-06-26
Chronic Pain, Couples, & Physical Activity
NCT04077164
TerminatedUnited StatesIllinois Institute of Technology2019-04-09
A Prospective Multicenter Longitudinal Cohort Study of the Mymobility Platform
NCT03737149
CompletedNot applicableAustralia, Italy, Netherlands, United StatesZimmer Biomet2018-10-22
A Clinical Study to Test Efficacy and Safety of Repeat Doses of CNTX-4975-05 in Patients With Osteoarthritis Knee Pain
NCT03660943
CompletedPhase 3United StatesCentrexion Therapeutics2018-09-09
Ultrasound-guided Genicular Nerve Block With Phenol for the Treatment of Chronic Pain Due to Knee Osteoarthritis
NCT03601533
Unknown statusNot applicableBrazilFederal University of São Paulo2018-06-05
Effects of tDCS in Elderly With Pain Due to Knee Osteoarthritis
NCT03117231
CompletedNot applicableBrazilFederal University of São Paulo2018-03-15
A Phase 3 Efficacy and Safety Study of Intra-articular CNTX-4975-05 (Capsaicin) vs Placebo in Subjects With OA Knee Pain
NCT03429049
CompletedPhase 3United StatesCentrexion Therapeutics2018-01-24
Effects of Action Observation Therapy on Pain, Functional Level and Brain Hemodynamic in Patients With Knee Osteoarthritis
NCT03245073
CompletedNot applicableTurkey (Türkiye)Acibadem University2017-09-15
AP-003-C Study to Confirm the Efficacy of Ampion™ in Adults With Pain Due to Severe Osteoarthritis of the Knee
NCT03182686
CompletedPhase 3United StatesAmpio Pharmaceuticals. Inc.2017-06-19
Radiofrequency For Chronic Knee Pain Post-Arthroplasty
NCT02931435
CompletedNot applicableUnited StatesRandall Brewer, MD, CPI2016-12
Saphenous Nerve Radiofrequency for Knee Osteoarthritis Trial
NCT02826850
Unknown statusPhase 3BrazilUniversity of Sao Paulo General Hospital2016-09
Intra-articular Lopain (MTX-071) Phase I/IIa Study in Chronic Osteoarthritic Knee Joint Pain
NCT02566564
CompletedPhase 1BelgiumGrünenthal GmbH2016-04
Diagnostic Genicular Nerve Block Prior to Radiofrequency Ablation for Knee Osteoarthritis Pain
NCT02578108
CompletedNot applicableUnited StatesNorthwestern University2015-10
Long Term Safety and Efficacy Study of Tanezumab in Subjects With Osteoarthritis of the Hip or Knee
NCT02528188
CompletedPhase 3Australia, Brazil, Bulgaria, Colombia and 14 morePfizer2015-07-21
Retrospective Study of the Results of Cooled Radiofrequency for Genicular Nerves Neurotomy in 40 Consecutive Patients With Osteoarthritis of the Knee and Painful Knee Arthroplasty
NCT03343808
CompletedHospital Son Espases2015-01-08
Efficacy of Cooled and Monopolar Radiofrequency Ablation of the Geniculate Nerves for the Treatment of Chronic Osteoarthritic Knee Pain
NCT02260869
TerminatedNot applicableUnited StatesMillennium Pain Center2015-01
Effect of Cranial Stimulation and Acupuncture on Pain, Functional Capability and Cerebral Function in Osteoarthritis
NCT01747070
CompletedNot applicableBrazilHospital de Clinicas de Porto Alegre2014-03

About Osteoarthritis, Knee

What is Osteoarthritis, Knee?

Osteoarthritis is the most common form of arthritis. It involves breakdown of cartilage and changes in the bone and tissues of a joint, most often in the knees, hips, hands and spine, and can cause pain, stiffness and reduced movement.

How is Osteoarthritis, Knee usually assessed?

Clinicians usually assess osteoarthritis through a history, physical examination of the joint and, in some cases, X-rays. Blood tests may help rule out other types of arthritis.

What kinds of treatments are studied for Osteoarthritis, Knee?

Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.

How can I find Osteoarthritis, Knee clinical trials in Canada?

This page lists 6 registry records for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.

Related conditions

Related interventions

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.