Duloxetine Impact on Postoperative Pain Control and Outcomes
TerminatedPhase 2NCT05611749
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
1. Evaluate differences between patients taking Duloxetine or placebo following lateral lumbar interbody fusion for postoperative narcotic consumption. 2. Evaluate differences between patients taking Duloxetine or placebo following lateral lumbar interbody fusion for postoperative pain, function, and quality of life. 3. Evaluate the correlation between preoperative screening tests (measuring pain centralization, anxiety, depression, and overall function) and patients' response to treatment (reduction in pain, anxiety, or depression and improvement in function).
Study details
- Official title
- Postoperative Duloxetine Impact on Pain Control and Patient Outcomes Following Lateral Lumbar Interbody Fusion: A Randomized Controlled Trial
- Conditions
- Acute Post-operative Pain
- Chronic Post Operative Pain
- Narcotic Use
- Opioid Use
- Opioid Addiction
- Interventions
- Drug: Duloxetine 60 MG
- Other: Placebo
- Sponsor
- Scripps Health
- Start date
- 2023-05-30
- Primary completion
- 2024-03-25
- Sex
- All
- Age range
- from 24 Years to 99 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- United States
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Age: \> 24 years * Male / Female not meeting any of the exclusion criteria Exclusion Criteria: * Age \< 24 years * Current use of antidepressant medications (including SSRI/SNRI, tricyclic, or Monoamine Oxidase Inhibitors) * History of seizure disorder * Diagnosis of bipolar disorder * History of syncope/orthostatic hypotension * Diagnosis of any condition with slowed gastric emptying * History of suicidal ideation * History of liver disease * History of chronic kidney disease/renal impairment * History of angle-closure glaucoma.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT05611749