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Opioid Use: clinical trials and information

"Opioid Use" is the term study registrants used on ClinicalTrials.gov. Registry labels are not always standard medical terms, and close variants of the same label appear as separate entries. In this snapshot the term appears on 100 chronic pain registry records worldwide.
6
Trials with Canadian sites
1
Recruiting in Canada
100
Registry records worldwide

Opioid Use clinical trials in Canada

6 trials, recruiting first
PhaseProvinces
Reducing Opioid Use for Chronic Pain Patients Following Surgery
NCT03675386
RecruitingNot applicableOntarioUniversity Health Network, Toronto2018-10-15
Optimizing Research Data Acquisition With Smart Pill Bottles
NCT06522698
Unknown statusNot applicableQuebecCiusss de L'Est de l'Île de Montréal2024-09-01
Improving Pain Disability With the Use of Oral Cannabinoids
NCT05351905
CompletedNot applicableOntarioUniversity Health Network, Toronto2022-11-22
Persistent Opioid Consumption After Major Abdominal Surgery and Its Determinants
NCT05197465
CompletedQuebecCentre hospitalier de l'Université de Montréal (CHUM)2022-02-13
Evaluation of a Patient-Centred, Multidisciplinary Opioid Tapering Program for Individuals With Chronic Non-Cancer Pain on Long Term Opioid Therapy
NCT04902547
CompletedNot applicableManitobaUniversity of Manitoba2021-05-01
The Prevalence of Chronic Pain and Continued Opioid Use After Cardiac Surgery
NCT03412448
Unknown statusQuebecMontreal Heart Institute2017-06-01

Opioid Use clinical trials worldwide (outside Canada)

94 trials, 11 recruiting or not yet recruiting. Recruiting first.

PhaseCountries
SPSIP Block Versus ESP Block for Chronic Pain After Unilateral Breast Surgery
NCT07674836
RecruitingNot applicableTurkey (Türkiye)Engin Çetin2026-07-01
Erector Spinae Block Versus Paravertebral Block on Chronic Pain After Mastectomy
NCT07561411
RecruitingNot applicableLebanonAmerican University of Beirut Medical Center2026-05-19
Evaluation of an Opioid Stewardship Program in Non-Cancer Patients
NCT07102446
RecruitingNot applicableSouth KoreaKorea University Guro Hospital2025-06-27
Improving Sleep and Reducing Opioid Use in Individuals With Chronic Pain
NCT06345872
RecruitingNot applicableUnited StatesUniversity of South Florida2024-12-11
Understanding the Acute Pain Phenotype in Patients Undergoing Surgery
NCT06466941
RecruitingUnited StatesBrigham and Women's Hospital2024-07-03
Translation and Validation of the COMM and ASI-SR
NCT06084520
RecruitingSwedenUppsala University2023-12-01
Pain AND Opioids After Surgery
NCT05877157
RecruitingCroatia, United KingdomUniversity of Aberdeen2023-09-25
Implementation and Effectiveness of Mindfulness Oriented Recovery Enhancement as an Adjunct to Methadone Treatment
NCT06032559
RecruitingPhase 3United StatesRutgers, The State University of New Jersey2023-09-04
Neuroimaging of Opioid Phase (OPAL)
NCT05905419
RecruitingNot applicableUnited StatesDuke University2023-06-01
Neural Mechanisms of Meditation for Opioid-Treated Chronic Low Back Pain
NCT05607381
RecruitingNot applicableUnited StatesUniversity of Utah2022-11-30
Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC
NCT05172739
RecruitingPhase 4GreeceUniversity of Crete2021-10-01
Patient-Centered Chronic Pain Care
NCT05256394
CompletedNot applicableUnited StatesUniversity of Florida2025-01-13
Medical Cannabis as an Opiate Alternative
NCT07194928
CompletedUnited StatesUniversity of Pennsylvania2024-09-01
Decreasing Loneliness to Optimize Pain Care
NCT06285032
CompletedNot applicableUnited StatesUniversity of Washington2024-08-09
Patient Reported Outcomes, Postoperative Pain and Pain Relief After Day Case Surgery (POPPY)
NCT06008496
CompletedUnited KingdomUniversity Hospital Plymouth NHS Trust2024-01-15
Managing Opioid Related Sleep Apnea With Acetazolamide
NCT06043830
CompletedPhase 2United StatesUniversity of California, San Diego2023-10-18
Physical Therapy Integrated With Mindfulness for Patients With Chronic Pain and Opioid Treatment
NCT05875207
CompletedNot applicableUnited StatesUniversity of Utah2023-08-14
The Effects of Daily Anti-inflammatory Supplementation on Foundation Pain Index Scores in Chronic Opiate Patients
NCT05896878
TerminatedNot applicableUnited StatesHudson Medical2023-07-10
Increasing Access to Evidence-based Treatment for Chronic Pain and Opioid Use Disorder: Adapting Acceptance and Commitment Therapy for Opioid Treatment Programs
NCT06581276
CompletedNot applicableUnited StatesMontefiore Medical Center2023-06-23
Enhanced Recovery After Major Surgery and Chronic Pain for Total Knee Arthroplasty
NCT05981105
Active, not recruitingNot applicableUnited StatesHospital for Special Surgery, New York2023-06-12
Duloxetine Impact on Postoperative Pain Control and Outcomes
NCT05611749
TerminatedPhase 2United StatesScripps Health2023-05-30
Psychological Intervention Using Smartphone Technology to Alleviate Malignant Pain
NCT05774197
CompletedNot applicableUnited StatesUniversity of Oklahoma2023-05-04
Mindfulness for Pain and Suicide
NCT05286112
CompletedNot applicableUnited StatesCanandaigua VA Medical Center2023-03-06
Testosterone Replacement to Alleviate Pain in Postmenopausal Women (TRAPP Trial)
NCT04895306
CompletedPhase 2United StatesBrigham and Women's Hospital2022-11-15
POINT - Preventing an Opioid Epidemic in Norway: Focusing on Treatment of Chronic Pain
NCT05828121
Unknown statusNot applicableNorwayHelse Stavanger HF2022-10-01
Slow Opioid Tapering Pilot Study of Patients Using Chronic Opioid Therapy
NCT05297396
CompletedNot applicableUnited StatesMayo Clinic2022-07-01
Impact of DuoTherm on Opioid Use and Low Back Pain
NCT04491175
CompletedNot applicableUnited StatesMMJ Labs LLC2022-06-23
Using Mobile Devices for Neurofeedback to Reduce Opioid Use in Chronic Pain
NCT04838925
Unknown statusNot applicableUnited StatesCrossComm, Inc.2022-06-22
The Adolescent Surgery Experience: A Mixed Methods Analysis
NCT05482919
CompletedUnited StatesChildren's Hospital of Philadelphia2022-06-14
Effects of the Nottingham Augmented Reality (AR) App for Arthritis Hand Joint Pain
NCT05634291
CompletedNot applicableUnited StatesVRx Medical Inc2022-06-13
Can Simplified and More Detailed Instructions Affect Post-Operative Narcotic Consumption
NCT03534102
WithdrawnPhase 4United StatesBrigham and Women's Hospital2022-06-06
The Association of Microbiome Patterns With Chronic Opioid Use
NCT05304403
Unknown statusUnited StatesUniversity of California, San Diego2022-04-01
NiteCAPP_HELPS_WD: Improving Sleep and Reducing Opioid Use in Chronic Pain Patients
NCT05226026
WithdrawnNot applicableUnited StatesUniversity of Missouri-Columbia2022-03-31
Optimization and Multi-Site Feasibility of Yoga for Chronic Pain in People in YOGAMAT-II - Phase II
NCT04641221
CompletedNot applicableUnited StatesButler Hospital2022-02-20
H-coil TMS to Reduce Pain: A Pilot Study Evaluating Relative Efficacy of the H1 vs H7 Coil
NCT04203199
TerminatedNot applicableUnited StatesWake Forest University Health Sciences2022-01-18
Postoperative Telehealth Mindfulness Intervention After Spine Surgery
NCT04648683
CompletedNot applicableUnited StatesVanderbilt University Medical Center2021-12-21
The Study of Hemp Oil CBD for Evaluation of Efficacy and Safety in Treatment of Pain, Anxiety and Insomnia Management
NCT04729244
Unknown statusPhase 1United StatesAdvanced Pain and Rehab Specialists2021-09-01
Evaluation of Medical Cannabis and Prescription Opioid Taper Support for Reduction of Pain and Opioid Dose in Patients With Chronic Non-Cancer Pain
NCT04827992
CompletedNot applicableUnited StatesMassachusetts General Hospital2021-08-23
Prospective Randomized Trial of CPAP for SDB in Patients Who Use Opioids
NCT04928157
CompletedPhase 2United StatesUniversity of California, San Diego2021-08-10
Personalized Feedback Intervention for Alcohol and Opioid Use Among Adults With Chronic Pain
NCT04592978
CompletedNot applicableUnited StatesSyracuse University2021-07-30
Predicting Chronic Pain Following Breast Surgery
NCT04967352
Unknown statusUnited StatesUniversity of California, San Diego2021-07-19
Predicting Chronic Opioid Use Following Lower Extremity Joint Arthroplasty
NCT04974463
Unknown statusUnited StatesUniversity of California, San Diego2021-07-19
Pharmacist-led Pharmacogenomic Clinical Service Within the Program of All-inclusive Care for the Elderly
NCT04971902
Unknown statusUnited StatesTabula Rasa HealthCare2021-07-01
Comparing the Impact of Mindful Interoceptive Mapping and Mindful Breathing on Pain and Opioid Use
NCT04523766
CompletedNot applicableUnited StatesUniversity of Utah2021-06-29
Comparing a Patient Self-Assessment Software to Treatment as Usual in Opioid Prescriber and Patient Opioid Outcomes
NCT04945525
Unknown statusNot applicableUnited StatesSure Med Compliance2021-05-26
Developing and Pilot Testing an Opioid Tapering Protocol
NCT04257695
CompletedNot applicableUnited StatesAlbert Einstein College of Medicine2021-05-04
Near-infrared Spectroscopy-based Neurofeedback as Adjunct to Mindfulness-Oriented Recovery Enhancement in Persons With Chronic Pain
NCT04902339
CompletedNot applicableUnited StatesUniversity of Utah2021-04-03
Opioid Approach Bias Modification
NCT04436926
CompletedNot applicableUnited StatesUniversity of California, San Francisco2021-03-01
Optimization and Multi-Site Feasibility of Yoga for Chronic Pain in People in YOGAMAT-II - Phase I
NCT04646148
CompletedNot applicableUnited StatesButler Hospital2021-03-01
Assessment of the Development of Postoperative Persistent Postoperative Pain
NCT05370924
Unknown statusItalyA.O.U. Città della Salute e della Scienza2021-02-20

About Opioid Use

What is Opioid Use?

"Opioid Use" is the term study registrants used on ClinicalTrials.gov. Registry labels are not always standard medical terms, and close variants of the same label appear as separate entries. In this snapshot the term appears on 100 chronic pain registry records worldwide.

How is Opioid Use usually assessed?

Assessment of chronic pain generally involves a clinician taking a detailed history, a physical examination and, where relevant, tests to look for underlying causes. Pain rating scales and questionnaires about function, sleep and mood are often used. The approach depends on the person and the condition.

What kinds of treatments are studied for Opioid Use?

Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.

How can I find Opioid Use clinical trials in Canada?

This page lists 6 registry records for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.

Related conditions

Related interventions

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.