Opioid Use: clinical trials and information
Opioid Use clinical trials in Canada
| Phase | Provinces | ||||
|---|---|---|---|---|---|
| Reducing Opioid Use for Chronic Pain Patients Following Surgery NCT03675386 | Recruiting | Not applicable | Ontario | University Health Network, Toronto | 2018-10-15 |
| Optimizing Research Data Acquisition With Smart Pill Bottles NCT06522698 | Unknown status | Not applicable | Quebec | Ciusss de L'Est de l'Île de Montréal | 2024-09-01 |
| Improving Pain Disability With the Use of Oral Cannabinoids NCT05351905 | Completed | Not applicable | Ontario | University Health Network, Toronto | 2022-11-22 |
| Persistent Opioid Consumption After Major Abdominal Surgery and Its Determinants NCT05197465 | Completed | Quebec | Centre hospitalier de l'Université de Montréal (CHUM) | 2022-02-13 | |
| Evaluation of a Patient-Centred, Multidisciplinary Opioid Tapering Program for Individuals With Chronic Non-Cancer Pain on Long Term Opioid Therapy NCT04902547 | Completed | Not applicable | Manitoba | University of Manitoba | 2021-05-01 |
| The Prevalence of Chronic Pain and Continued Opioid Use After Cardiac Surgery NCT03412448 | Unknown status | Quebec | Montreal Heart Institute | 2017-06-01 |
Opioid Use clinical trials worldwide (outside Canada)
94 trials, 11 recruiting or not yet recruiting. Recruiting first.
| Phase | Countries | ||||
|---|---|---|---|---|---|
| SPSIP Block Versus ESP Block for Chronic Pain After Unilateral Breast Surgery NCT07674836 | Recruiting | Not applicable | Turkey (Türkiye) | Engin Çetin | 2026-07-01 |
| Erector Spinae Block Versus Paravertebral Block on Chronic Pain After Mastectomy NCT07561411 | Recruiting | Not applicable | Lebanon | American University of Beirut Medical Center | 2026-05-19 |
| Evaluation of an Opioid Stewardship Program in Non-Cancer Patients NCT07102446 | Recruiting | Not applicable | South Korea | Korea University Guro Hospital | 2025-06-27 |
| Improving Sleep and Reducing Opioid Use in Individuals With Chronic Pain NCT06345872 | Recruiting | Not applicable | United States | University of South Florida | 2024-12-11 |
| Understanding the Acute Pain Phenotype in Patients Undergoing Surgery NCT06466941 | Recruiting | United States | Brigham and Women's Hospital | 2024-07-03 | |
| Translation and Validation of the COMM and ASI-SR NCT06084520 | Recruiting | Sweden | Uppsala University | 2023-12-01 | |
| Pain AND Opioids After Surgery NCT05877157 | Recruiting | Croatia, United Kingdom | University of Aberdeen | 2023-09-25 | |
| Implementation and Effectiveness of Mindfulness Oriented Recovery Enhancement as an Adjunct to Methadone Treatment NCT06032559 | Recruiting | Phase 3 | United States | Rutgers, The State University of New Jersey | 2023-09-04 |
| Neuroimaging of Opioid Phase (OPAL) NCT05905419 | Recruiting | Not applicable | United States | Duke University | 2023-06-01 |
| Neural Mechanisms of Meditation for Opioid-Treated Chronic Low Back Pain NCT05607381 | Recruiting | Not applicable | United States | University of Utah | 2022-11-30 |
| Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC NCT05172739 | Recruiting | Phase 4 | Greece | University of Crete | 2021-10-01 |
| Patient-Centered Chronic Pain Care NCT05256394 | Completed | Not applicable | United States | University of Florida | 2025-01-13 |
| Medical Cannabis as an Opiate Alternative NCT07194928 | Completed | United States | University of Pennsylvania | 2024-09-01 | |
| Decreasing Loneliness to Optimize Pain Care NCT06285032 | Completed | Not applicable | United States | University of Washington | 2024-08-09 |
| Patient Reported Outcomes, Postoperative Pain and Pain Relief After Day Case Surgery (POPPY) NCT06008496 | Completed | United Kingdom | University Hospital Plymouth NHS Trust | 2024-01-15 | |
| Managing Opioid Related Sleep Apnea With Acetazolamide NCT06043830 | Completed | Phase 2 | United States | University of California, San Diego | 2023-10-18 |
| Physical Therapy Integrated With Mindfulness for Patients With Chronic Pain and Opioid Treatment NCT05875207 | Completed | Not applicable | United States | University of Utah | 2023-08-14 |
| The Effects of Daily Anti-inflammatory Supplementation on Foundation Pain Index Scores in Chronic Opiate Patients NCT05896878 | Terminated | Not applicable | United States | Hudson Medical | 2023-07-10 |
| Increasing Access to Evidence-based Treatment for Chronic Pain and Opioid Use Disorder: Adapting Acceptance and Commitment Therapy for Opioid Treatment Programs NCT06581276 | Completed | Not applicable | United States | Montefiore Medical Center | 2023-06-23 |
| Enhanced Recovery After Major Surgery and Chronic Pain for Total Knee Arthroplasty NCT05981105 | Active, not recruiting | Not applicable | United States | Hospital for Special Surgery, New York | 2023-06-12 |
| Duloxetine Impact on Postoperative Pain Control and Outcomes NCT05611749 | Terminated | Phase 2 | United States | Scripps Health | 2023-05-30 |
| Psychological Intervention Using Smartphone Technology to Alleviate Malignant Pain NCT05774197 | Completed | Not applicable | United States | University of Oklahoma | 2023-05-04 |
| Mindfulness for Pain and Suicide NCT05286112 | Completed | Not applicable | United States | Canandaigua VA Medical Center | 2023-03-06 |
| Testosterone Replacement to Alleviate Pain in Postmenopausal Women (TRAPP Trial) NCT04895306 | Completed | Phase 2 | United States | Brigham and Women's Hospital | 2022-11-15 |
| POINT - Preventing an Opioid Epidemic in Norway: Focusing on Treatment of Chronic Pain NCT05828121 | Unknown status | Not applicable | Norway | Helse Stavanger HF | 2022-10-01 |
| Slow Opioid Tapering Pilot Study of Patients Using Chronic Opioid Therapy NCT05297396 | Completed | Not applicable | United States | Mayo Clinic | 2022-07-01 |
| Impact of DuoTherm on Opioid Use and Low Back Pain NCT04491175 | Completed | Not applicable | United States | MMJ Labs LLC | 2022-06-23 |
| Using Mobile Devices for Neurofeedback to Reduce Opioid Use in Chronic Pain NCT04838925 | Unknown status | Not applicable | United States | CrossComm, Inc. | 2022-06-22 |
| The Adolescent Surgery Experience: A Mixed Methods Analysis NCT05482919 | Completed | United States | Children's Hospital of Philadelphia | 2022-06-14 | |
| Effects of the Nottingham Augmented Reality (AR) App for Arthritis Hand Joint Pain NCT05634291 | Completed | Not applicable | United States | VRx Medical Inc | 2022-06-13 |
| Can Simplified and More Detailed Instructions Affect Post-Operative Narcotic Consumption NCT03534102 | Withdrawn | Phase 4 | United States | Brigham and Women's Hospital | 2022-06-06 |
| The Association of Microbiome Patterns With Chronic Opioid Use NCT05304403 | Unknown status | United States | University of California, San Diego | 2022-04-01 | |
| NiteCAPP_HELPS_WD: Improving Sleep and Reducing Opioid Use in Chronic Pain Patients NCT05226026 | Withdrawn | Not applicable | United States | University of Missouri-Columbia | 2022-03-31 |
| Optimization and Multi-Site Feasibility of Yoga for Chronic Pain in People in YOGAMAT-II - Phase II NCT04641221 | Completed | Not applicable | United States | Butler Hospital | 2022-02-20 |
| H-coil TMS to Reduce Pain: A Pilot Study Evaluating Relative Efficacy of the H1 vs H7 Coil NCT04203199 | Terminated | Not applicable | United States | Wake Forest University Health Sciences | 2022-01-18 |
| Postoperative Telehealth Mindfulness Intervention After Spine Surgery NCT04648683 | Completed | Not applicable | United States | Vanderbilt University Medical Center | 2021-12-21 |
| The Study of Hemp Oil CBD for Evaluation of Efficacy and Safety in Treatment of Pain, Anxiety and Insomnia Management NCT04729244 | Unknown status | Phase 1 | United States | Advanced Pain and Rehab Specialists | 2021-09-01 |
| Evaluation of Medical Cannabis and Prescription Opioid Taper Support for Reduction of Pain and Opioid Dose in Patients With Chronic Non-Cancer Pain NCT04827992 | Completed | Not applicable | United States | Massachusetts General Hospital | 2021-08-23 |
| Prospective Randomized Trial of CPAP for SDB in Patients Who Use Opioids NCT04928157 | Completed | Phase 2 | United States | University of California, San Diego | 2021-08-10 |
| Personalized Feedback Intervention for Alcohol and Opioid Use Among Adults With Chronic Pain NCT04592978 | Completed | Not applicable | United States | Syracuse University | 2021-07-30 |
| Predicting Chronic Pain Following Breast Surgery NCT04967352 | Unknown status | United States | University of California, San Diego | 2021-07-19 | |
| Predicting Chronic Opioid Use Following Lower Extremity Joint Arthroplasty NCT04974463 | Unknown status | United States | University of California, San Diego | 2021-07-19 | |
| Pharmacist-led Pharmacogenomic Clinical Service Within the Program of All-inclusive Care for the Elderly NCT04971902 | Unknown status | United States | Tabula Rasa HealthCare | 2021-07-01 | |
| Comparing the Impact of Mindful Interoceptive Mapping and Mindful Breathing on Pain and Opioid Use NCT04523766 | Completed | Not applicable | United States | University of Utah | 2021-06-29 |
| Comparing a Patient Self-Assessment Software to Treatment as Usual in Opioid Prescriber and Patient Opioid Outcomes NCT04945525 | Unknown status | Not applicable | United States | Sure Med Compliance | 2021-05-26 |
| Developing and Pilot Testing an Opioid Tapering Protocol NCT04257695 | Completed | Not applicable | United States | Albert Einstein College of Medicine | 2021-05-04 |
| Near-infrared Spectroscopy-based Neurofeedback as Adjunct to Mindfulness-Oriented Recovery Enhancement in Persons With Chronic Pain NCT04902339 | Completed | Not applicable | United States | University of Utah | 2021-04-03 |
| Opioid Approach Bias Modification NCT04436926 | Completed | Not applicable | United States | University of California, San Francisco | 2021-03-01 |
| Optimization and Multi-Site Feasibility of Yoga for Chronic Pain in People in YOGAMAT-II - Phase I NCT04646148 | Completed | Not applicable | United States | Butler Hospital | 2021-03-01 |
| Assessment of the Development of Postoperative Persistent Postoperative Pain NCT05370924 | Unknown status | Italy | A.O.U. Città della Salute e della Scienza | 2021-02-20 |
About Opioid Use
What is Opioid Use?
"Opioid Use" is the term study registrants used on ClinicalTrials.gov. Registry labels are not always standard medical terms, and close variants of the same label appear as separate entries. In this snapshot the term appears on 100 chronic pain registry records worldwide.
How is Opioid Use usually assessed?
Assessment of chronic pain generally involves a clinician taking a detailed history, a physical examination and, where relevant, tests to look for underlying causes. Pain rating scales and questionnaires about function, sleep and mood are often used. The approach depends on the person and the condition.
What kinds of treatments are studied for Opioid Use?
Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.
How can I find Opioid Use clinical trials in Canada?
This page lists 6 registry records for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.
Related conditions
Related interventions
- Drug: gabapentin (2)
- Drug: placebo (2)
- Drug: Dexamethasone (2)
- Behavioral: Mindfulness Oriented Recovery Enhancement (2)
- Other: placebo (2)
- Other: Observation (1)
- Behavioral: Acceptance and Commitment Therapy (1)
- Drug: Ketamine (1)
- Device: TENS (1)
- Drug: Cannabis (1)
- Behavioral: Mindfulness-Oriented Recovery Enhancement (1)
- Other: Neurofeedback (1)
- Other: Questionnaires (1)
- Behavioral: Health Education (1)
- Other: usual care (1)
- Other: Standard of Care (1)
- Behavioral: Treatment as Usual (1)
- Behavioral: Acceptance and Commitment Therapy (ACT) (1)
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.