Comparing Pain Outcomes of Treatment Strategies for Osteoarthritis Knee Patients

Inclusion Criteria: 1. Age ≥ 21 years 2. Able to understand the informed consent form and provide written informed consent and able to complete outcome measures 3. Chronic knee pain for longer than 3 months that interferes with functional activities (for example, ambulation, prolonged standing, etc.) 4. Continued pain in the target knee despite at least 3 months of conservative treatments, including activity modification, home exercise, protective weight bearing, and/or analgesics (for example, acetaminophen or non-steroidal anti-inflammatory drugs \[NSAIDs\] etc.) 5. Positive response (defined as a decrease in numeric pain scores of at least 50%) to a single genicular nerve block of the index knee 6. Pain on VAS ≥ 6 on an 11-point scale for the index knee 7. Radiologic confirmation of arthritis (x-ray/MRI/CT) of OA grade of 2 (mild), 3 (moderate) or 4 (severe) noted within 6 months for the index knee 8. An intra-articular HA injection is indicated as an appropriate treatment option 9. WOMAC Knee Score group at baseline of Score of ≥ 2 (0 to 4 scale) on WOMAC question 1 (Pain) and a mean score of ≥ 1.5 on all five questions of the WOMAC pain subscale 10. Agree to see one physician (study physician) for knee pain during the study period 11. Willing to delay any surgical intervention for the index knee for the period of the study follow up 12. Willing to comply with the requirements of this protocol for the full duration of the study Exclusion Criteria: 1. Evidence of inflammatory arthritis (for example, rheumatoid arthritis) or other systemic inflammatory condition (for example, gout, fibromyalgia) that could cause knee pain 2. Evidence of neuropathic pain secondary to other causes (e.g., sciatica), apart from OA knee, affecting the index knee 3. Previous or pending lower limb amputation 4. Intra-articular steroid or PRP injection or Radiofrequency lesioning into the index knee within 180 days from randomization 5. Hyaluronic acid injection, PRP injection, stem cell, or arthroscopic debridement/lavage injection into the index knee within 180 days from randomization 6. Prior partial, resurfacing, or total knee arthroplasty of the index knee (residual hardware) 7. Clinically significant ligamentous laxity of the index knee 8. Clinically significant valgus/varus deformities or evidence of pathology (other than osteoarthritis of knee) that materially affects gait or function of the knee or is the underlying cause of the knee pain and/or functional limitations 9…