Methadone Pharmacokinetics in End-stage Renal Disease
Unknown statusNCT06056245
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The goal of this observational study is to describe the influence of renal function on the pharmacokinetics of methadone used through an intravenous patient-controlled analgesia (IV-PCA) pump for the management of acute postoperative pain. After surgery the participants will use an IV-PCA of methadone and blood samples will be withdrawn to measure the plasmatic levels of it. The main question the study aims to answer is: • Is the pharmacokinetic of methadone used in an IV-PCA pump impaired in patients with chronic kidney disease?
Study details
- Official title
- Postoperative Pharmacokinetics of Methadone in Patients With Chronic Kidney Disease
- Interventions
- Procedure: Preoperative step
- Drug: Intraoperative
- Drug: Post-operative
- Sponsor
- Pontificia Universidad Catolica de Chile
- Start date
- 2024-04-05
- Primary completion
- 2024-12-31
- Sex
- All
- Age range
- from 18 Years
- Results posted
- No results posted in this snapshot
- Countries
- Chile
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Patients with chronic kidney disease (CrCl 15-60 ml/min) * Patients over 18 years old undergoing surgery requiring general anesthesia with subsequent use of intravenous methadone patient-controlled analgesia * Hospital stay ≥ 48 hours * Body mass index 18-35 kg/m2 Exclusion Criteria: * History of liver disease * Need for dialysis (hemo or peritoneal dialysis) * Use of home oxygen therapy * American Society of Anesthesiologists (ASA) physical status IV-V * Pregnancy * Chronic opioid use * Methadone allergy * Prolonged QT interval * Use of antiarrhythmics that prolong the QT interval * Inability to understand the proper use of PCA
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT06056245