Pain Phenotyping in Knee OA: a Pilot Trial

Brief summary (from the registry)

Osteoarthritis (OA) is disease in which the joint breaks down, causing pain. The decision to surgically replace the knee, a procedure called total knee arthroplasty (TKA), depends on x-ray results as well as pain and dysfunction. Despite TKA resulting in good outcomes for most patients, between 1 in 10 and 1 in 5 patients remain in significant pain - i.e., are 'TKA non-responders'. Two pain conditions - myofascial pain syndrome (MPS) and central sensitization - frequently coexist with signs of OA and may contribute to a TKA non-responder profile. MPS, caused by knots within skeletal muscle, can contribute to an OA patient's pain and dysfunction. In central sensitization, faulty pain sensing leads to increased pain sensitivity. However, there is currently no established process to identify these sources of pain and potential associated TKA non-responder risk. Our research aims conduct a pilot study to examine the impact of pain diagnosis tools to help orthopedic surgeons identify potential TKA nonresponders. This new approach may increase healthcare efficiency (reduce TKA waitlist and length of hospital stay), and help patients receive the right care at the right time.

Study details

Official title

Prediction Modelling of TKA Non-responders Using Clinical and Pain Sensitization Measures

Conditions

• Osteo Arthritis Knee
• Chronic Post-operative Pain

Interventions

• Other: n/a, observational

Sponsor

University Health Network, Toronto

Start date

2023-09-18

Primary completion

2025-06-18

Sex

All

Age range

from 18 Years

Results posted

No results posted in this snapshot

Countries

Canada

Total sites listed

2

Eligibility criteria

Canadian sites (2)