Pain Control in Episodic and Chronic Migraine
CompletedNot applicableNCT06599905
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The phenomenon of offset analgesia (OA) refers to a disproportionately large decrease in perceived pain following a slight reduction in the intensity of a noxious heat stimulus. This phenomenon is considered as an indicator of the activation of the endogenous pain modulation system, whose dysfunction is implicated in the pathophysiology of migraine and other chronic pain conditions. This study aims to investigate pain processing mechanisms using the OA paradigm in individuals with episodic migraine (EM) during different phases of the migraine cycle and in those with chronic migraine (CM), with and without medication overuse headache (CMwoMOH and CM-MOH, respectively). A population of healthy subjects matched by sex and age will also be enrolled
Study details
- Official title
- Endogenous Pain Control Mechanisms Throughout the Migraine Cycle and in Chronic Migraine
- Conditions
- Interventions
- Other: Episodic Migraine (EM)
- Other: Chronic Migraine (CM)
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
- Start date
- 2021-06-15
- Primary completion
- 2024-01-15
- Sex
- All
- Age range
- from 18 Years to 70 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- Italy
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * patients affected by episodic or chronic migraine according to the International Headache Society (IHS) Classification (3rd edition), aged 18 to 70 years Exclusion Criteria: * any other headache diagnosis according to the IHS classification * other acute or chronic pain conditions * serious internal, psychiatric, or neurological systemic diseases * pregnancy, breastfeeding, skin pathologies in the tested trigeminal nerve area (V1) * poor sleep quality the night before testing * alcohol consumption or intense exercise within 24 hours prior to examination * women were not assessed during their menstrual cycle. * Use of migraine prophylactic medication for patients with EM.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT06599905