The Effect of Intrathecal Morphine and Erector Spina Plan Block on Serum Cytokine Levels and Chronic Pain in Caesarean Section Surgery
Active, not recruitingNCT06684015
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Working Title The Effect of Intrathecal Morphine and Erector Spina Plan Block on Serum Cytokine Levels and Chronic Pain in Caesarean Section Surgery Study Description This study aims to evaluate the effects of intrathecal morphine added as an adjuvant to local anesthesia during spinal anesthesia and the erector spinae plane block applied at the end of cesarean surgery on postoperative serum cytokine levels, pain intensity, need for rescue analgesia, hospital anxiety and depression levels, quality of obstetric recovery, and the development of chronic postoperative pain. Study Type Study Design: Observational Model: Two parallel groups Time Perspective: Prospective Interventions Intervention Type: Drug and Block Procedure Details: In patients included in the study, intrathecal morphine is administered as an adjuvant to local anesthesia during spinal anesthesia first group. At the end of surgery, an erector spinae plane block is performed other group. Primary Outcome Measures Serum Cytokine Levels Time Frame: 0., 6. and 24. Hours Assessment Method: Serum biochemical analyses Pain Intensity and Need for Rescue Analgesia Time Frame: 2., 4., 6., 12. and 24. hours, assessed using the Numeric Rating Scale(NRS) Hospital Anxiety and Depression Levels Time Frame: Preoperative and at 24 hours postoperatively Assessment Method: Hospital Anxiety and Depression Scale (HADS) Quality of Obstetric Recovery Score Time Frame: At 24 hours postoperatively Chronic Postoperative Pain Development Time Frame: Evaluated at 4 months postoperatively Assessment Method: Short Form McGill Pain Questionnaire-2
Study details
- Official title
- The Effect of Intrathecal Morphine and Erector Spina Plan Block on Serum Cytokine Levels and Chronic Pain in Caesarean Section Surgery
- Conditions
- Cesarean Delivery
- Postoperative Pain
- Cytokine Levels
- Chronic Pain, Postoperative
- Interventions
- Drug: İNTRATECHAL MORPHİNE GROUP
- Procedure: Erector Spinae Plane Block
- Sponsor
- Ankara University
- Start date
- 2024-03-01
- Primary completion
- 2024-11-30
- Sex
- Female
- Age range
- from 18 Years
- Results posted
- No results posted in this snapshot
- Countries
- Turkey (Türkiye)
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * 18 years and older * ASA II * Elective surgery * Spinal anesthesia * To accept participation in the study and regional anesthesia applications Exclusion Criteria: * Under 18 years old * BMI (body mass index) \>35 kilograms/meter2 (kg/m2) * ASA III and above * Multiple pregnancy * Previous abdominal surgery * History of malignancy * Contraindication for regional anesthesia * Known history of allergy to the drugs to be used * Presence of chronic pain (migraine, fibromyalgia, etc.) * History of substance abuse * Regular use of painkillers (simple analgesics, gabapentinoids, opioids)
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT06684015