Transition From Acute to Chronic Opioid Use and Chronic Pain

Brief summary (from the registry)

In the current opioid crisis, the use of opioids as the main pain management method is recognized as a consistent risk factor for chronic opioid use and the development of Opioid Use Disorder (OUD), as well as related complications like overdose fatalities among surgical patients. The most recent data suggests that 3.1%-10.5% of surgical patients are at risk of developing OUD. On average, there are over 40 million major surgeries that require post-op pain management, taking place in the United States each year. This puts over 1 million American surgical patients at risk for opioid dependency and misuse. This is a prospective randomized controlled intervention study that will examine the physical and emotional outcomes of surgical patients who receive intraoperative Opioid-Free Anesthesia (OFA) supplemented with Non-Opioid Analgesia (NOAs), and how this relates to surgical patients who receive intraoperative Opioid-Based Anesthesia (OBA).

Study details

Official title

The Role of Intraoperative Opioids in the Transition From Acute to Chronic Opioid Use and Chronic Pain

Conditions

• Opioid Use Disorder

Interventions

• Drug: Opioid-free anesthesia
• Drug: Opioid-based anesthesia

Sponsor

Jacques E. Chelly

Organization

University of Pittsburgh

Start date

2026-07-01

Primary completion

2030-12-01

Sex

All

Age range

from 18 Years

Results posted

No results posted in this snapshot

Countries

United States

Total sites listed

1

Eligibility criteria