Opioid Use Disorder: clinical trials and information
Opioid Use Disorder clinical trials in Canada
| Phase | Provinces | ||||
|---|---|---|---|---|---|
| Superficial Parasternal Intercostal Plane Block in Cardiac Surgery Trial NCT06028126 | Completed | Not applicable | Alberta, British Columbia, Nova Scotia, Ontario | Unity Health Toronto | 2023-09-08 |
Opioid Use Disorder clinical trials worldwide (outside Canada)
34 trials, 9 recruiting or not yet recruiting. Recruiting first.
| Phase | Countries | ||||
|---|---|---|---|---|---|
| Digital Treatment for Chronic Pain and Addiction in Veterans With Opioid Use Disorder Receiving Buprenorphine NCT07361432 | Not yet recruiting | Phase 3 | United States | VA Office of Research and Development | 2026-11-02 |
| A Study of Cebranopadol for Opioid Withdrawal Symptoms in Adults With Chronic Pain NCT07874620 | Not yet recruiting | Phase 2 | United States | Adneuris Therapeutics, Inc. | 2026-09 |
| Low-Intensity Focused Ultrasound and the Complex Patient NCT06297200 | Recruiting | Not applicable | United States | Virginia Polytechnic Institute and State University | 2024-12-04 |
| Adolescent Outcomes of Post-operative Opioid EXposure NCT06350409 | Recruiting | United States | Sharon Levy | 2024-11-12 | |
| Combined THC and CBD for OUD and Chronic Pain NCT06544291 | Recruiting | Phase 2 | United States | Yale University | 2024-10-22 |
| Focused Ultrasound for the Complex Patient NCT06453109 | Recruiting | Not applicable | United States | Washington D.C. Veterans Affairs Medical Center | 2024-04-29 |
| Translation and Validation of the COMM and ASI-SR NCT06084520 | Recruiting | Sweden | Uppsala University | 2023-12-01 | |
| Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial NCT06565416 | Recruiting | Not applicable | United States | University of New Mexico | 2023-06-01 |
| Divided or Single Exposure (DOSE) Study NCT05459402 | Recruiting | Phase 2, Phase 3 | United States | University of Maryland, Baltimore | 2023-02-21 |
| Transition From Acute to Chronic Opioid Use and Chronic Pain NCT07211399 | Withdrawn | Early phase 1 | United States | Jacques E. Chelly | 2026-07-01 |
| Mindfulness-Based Ecological Momentary Intervention for Opioid Use Disorder and Chronic Pain NCT06947122 | Completed | Not applicable | United States | Arizona State University | 2026-02-10 |
| Emotional Awareness and Expression Therapy for Chronic Pain and Opioid Use Disorder NCT06865560 | Completed | Not applicable | United States | University of Michigan | 2025-06-03 |
| The Acupuncture for Pain, Opioid Use Disorder and Mood NCT06543355 | Completed | Not applicable | United States | Albert Einstein College of Medicine | 2025-01-06 |
| Pain Self-Management and Treatment Engagement for Patients Taking Opioids NCT06855732 | Active, not recruiting | Not applicable | United States | University of Pittsburgh | 2024-11-25 |
| Assessing the Efficacy of Self-Driven Repetitive Artmaking Practice NCT06554431 | Completed | Not applicable | United States | Montefiore Medical Center | 2024-07-02 |
| Pain Self-Management and Patient-Oriented Dosing for Pain and in Retention Opioid Treatment NCT06367387 | Active, not recruiting | Phase 4 | United States | Erin Winstanley | 2024-05-28 |
| Mobile & Online-Based Interventions to Lessen Pain NCT05152134 | Completed | Phase 3 | United States | Stanford University | 2023-08-23 |
| Stepped Care for Patients to Optimize Whole Recovery NCT05155163 | Active, not recruiting | Not applicable | United States | Yale University | 2023-06-28 |
| Increasing Access to Evidence-based Treatment for Chronic Pain and Opioid Use Disorder: Adapting Acceptance and Commitment Therapy for Opioid Treatment Programs NCT06581276 | Completed | Not applicable | United States | Montefiore Medical Center | 2023-06-23 |
| Pain Care at Home to Amplify Function (Pain CHAMP) NCT05333341 | Active, not recruiting | Not applicable | United States | Yale University | 2023-06-16 |
| Tai Chi Easy for Opioid Use Disorder, Anxiety, and Chronic Pain NCT05850533 | Completed | Not applicable | United States | Asana Recovery | 2023-05-22 |
| Healing Opioid Misuse and Pain Through Engagement (HOPE) Trial NCT05571917 | Active, not recruiting | Not applicable | United States | University of New Mexico | 2023-05-05 |
| Auricular Acupressure as a Non-Opioid Adjuvant in Opioid Tolerant Patients NCT05711537 | Completed | Not applicable | United States | Wake Forest University Health Sciences | 2023-04-17 |
| STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis NCT05603702 | Active, not recruiting | Phase 1 | United States | Indiana University | 2023-03-17 |
| IMPOWR-ME Project 1: Trial of Yoga and Physical Therapy Onsite at Opioid Treatment Programs NCT05492825 | Active, not recruiting | Not applicable | United States | Albert Einstein College of Medicine | 2023-02-27 |
| Virtual Reality for Chronic Pain and Opioid Use Disorder Pilot NCT05546749 | Completed | Not applicable | United States | Albert Einstein College of Medicine | 2023-02-08 |
| Computer Based Treatment for Cognitive Behavioral Therapy and Cooperative Pain Education and Self-Management NCT05204576 | Completed | Not applicable | United States | Yale University | 2022-07-15 |
| An Adaptive Walking Intervention to Manage Chronic Pain in Veterans With Opioid Use Disorder Engaged in Opioid Agonist Treatment NCT05051644 | Completed | Phase 1 | United States | VA Office of Research and Development | 2022-04-01 |
| Cannabidiol in Opioid Use Disorder and Chronic Pain NCT04587791 | Completed | Early phase 1 | United States | Yale University | 2021-12-08 |
| Pain and Opioid Management in Older Adults NCT05037682 | Unknown status | Not applicable | United States | University of Oklahoma | 2020-09-30 |
| Long-Term Opioid Therapy in Chronic Non-Cancer Pain: Risks and Benefits NCT06063902 | Enrolling by invitation | Sweden | Uppsala University | 2019-01-14 | |
| Establishing Efficacy of a Functional-Restoration Based CAM Pain Management Program in Post-9/11 Veterans NCT02657317 | Completed | Not applicable | United States | The University of Texas Health Science Center at San Antonio | 2016-04-04 |
| Phase II Pharmacokinetics Study of CAM2038 NCT02710526 | Completed | Phase 2 | United States | Braeburn Pharmaceuticals | 2015-02 |
| Buprenorphine Treatment: A Safe Alternative for Opioid Dependent Pain Patients NCT01841931 | Terminated | Phase 4 | United States | Theresa Jacob, PhD, MPH | 2013-02 |
About Opioid Use Disorder
What is Opioid Use Disorder?
"Opioid Use Disorder" is the term study registrants used on ClinicalTrials.gov. Registry labels are not always standard medical terms, and close variants of the same label appear as separate entries. In this snapshot the term appears on 35 chronic pain registry records worldwide.
How is Opioid Use Disorder usually assessed?
Assessment of chronic pain generally involves a clinician taking a detailed history, a physical examination and, where relevant, tests to look for underlying causes. Pain rating scales and questionnaires about function, sleep and mood are often used. The approach depends on the person and the condition.
What kinds of treatments are studied for Opioid Use Disorder?
Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.
How can I find Opioid Use Disorder clinical trials in Canada?
This page lists 1 registry record for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.
Related conditions
Related interventions
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.