Investigating the Role of Central Pain Hypersensitivity in Skeletal Muscle Neural Drive
RecruitingNCT07281651
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Background: pain lasting for 12 weeks or beyond, which is often referred to as chronic pain, is common for people living with musculoskeletal conditions (e.g. arthritis, low back pain and fibromyalgia). Pain is often not directly related to the degree of muscle or joint damage. Adaptations of the central nervous system (brain, spinal cord and nerves) often occur in chronic musculoskeletal conditions and can influence how we feel pain (central pain hypersensitivity). Pain can impact on muscle activity and movement. Muscle activity is also governed by nerve signals from the central nervous system (neural drive). The goal of this cross-sectional observational study is to investigate whether chronic musculoskeletal pain is associated with altered nerve signalling (neural drive) to skeletal muscles in adults 40 years or over with chronic knee pain, fibromyalgia and healthy pain free volunteers. The main questions it aims to answer are:- * Is central pain hypersensitivity associated with altered nerve signalling to skeletal muscles in adults 40 years or over with chronic pain (knee pain and for fibromyalgia) as well as healthy volunteers? * Is altered nerve signalling to skeletal muscles associated with physical function and disability? Participants will be asked to:- * Have sensory testing to determine how they feel pain * Complete static leg and arm muscle contractions with electrodes on the skin to measure muscle electrical activity * Complete questionnaires * Perform a short set of mobility tasks including walking, rising from a chair and balancing.
Study details
- Official title
- Investigating the Role of Central Pain Hypersensitivity in Skeletal Muscle Neural Drive, in People With Knee Pain, and in People With Fibromyalgia Syndrome (Pain-Neural Drive)
- Conditions
- Interventions
- Other: Central Pain Hypersensitivity
- Sponsor
- University of Nottingham
- Start date
- 2025-11-24
- Primary completion
- 2026-09
- Sex
- All
- Age range
- from 40 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- United Kingdom
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: Knee pain group * History of knee pain with an intensity level of 4 out of 10 or greater (where 0 is no pain and 10 is the worst pain imaginable) for most days in the past 3 months Fibromyalgia group * Fibromyalgia diagnosis (participant self-reporting a previous diagnosis by a clinician) * Pain with an intensity level of 4 out of 10 or greater (where 0 is no pain and 10 is the worst pain imaginable) for most days in the past 3 months Control group \- Pain free individuals without known osteoarthritis Exclusion Criteria: * BMI\>35 * Body weight of 250kg or higher * Pregnancy (women) * Inability to give consent * Inability to meet the requirements of clinical assessment * Performed strenuous physical exercise in the past 24 hours prior to testing * Consumed alcohol on day of testing * Consumed caffeine on day of testing
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT07281651