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Chronic Knee Pain: clinical trials and information

Osteoarthritis is the most common form of arthritis. It involves breakdown of cartilage and changes in the bone and tissues of a joint, most often in the knees, hips, hands and spine, and can cause pain, stiffness and reduced movement.
1
Trials with Canadian sites
1
Recruiting in Canada
41
Registry records worldwide

Chronic Knee Pain clinical trials in Canada

1 trial, recruiting first
PhaseProvinces
Neurolysis for the Treatment of Medial Chronic Knee Pain Due to Osteoarthritis
NCT07178951
RecruitingNot applicableOntarioFUSMobile Inc.2026-09-09

Chronic Knee Pain clinical trials worldwide (outside Canada)

40 trials, 15 recruiting or not yet recruiting. Recruiting first.

PhaseCountries
Effects of Photobiomodulation on Inflammation and Chronic Pain in Knee Osteoarthritis (EPIC-KO)
NCT07079969
Not yet recruitingNot applicableUnited StatesUniversity of Florida2026-09
Personalized Analgesia Through Central Nervous System Engagement to Unlock Performance
NCT07759336
Not yet recruitingPhase 4United StatesBenedict Alter2026-08
Treating Chronic Pain of Peripheral Nerve Origin With the Novel Noninvasive Hypersound Neuromodulation System
NCT06626854
Not yet recruitingEarly phase 1Hypersound Medical Inc2026-06-10
Nerve to Vastus Medialis Branches in Chronic Knee Pain
NCT07703293
RecruitingTurkey (Türkiye)Diskapi Teaching and Research Hospital2026-05-20
Sonographic Thigh Adjustment Ratio and Subcutaneous Fat Thickness as Predictors of Genicular Nerve Block Response in Knee Osteoarthritis
NCT07712419
RecruitingTurkey (Türkiye)Gaziosmanpasa Research and Education Hospital2026-05-15
Individual Differences in Gait and Osteoarthritis Pain
NCT07308873
RecruitingUnited StatesUniversity of Pittsburgh2026-01-07
Investigating the Role of Central Pain Hypersensitivity in Skeletal Muscle Neural Drive
NCT07281651
RecruitingUnited KingdomUniversity of Nottingham2025-11-24
Evaluating the Auricular Point Acupressure-Self Management Program for Chronic Musculoskeletal Pain Among Rural Populations
NCT07179016
RecruitingNot applicableUnited StatesThe University of Texas Health Science Center, Houston2025-09-11
Laterality Training and Pain Drawings
NCT07078084
Not yet recruitingNot applicableUnited StatesHawaii Pacific University2025-08
Self-Management and Exercise Programme Using Mobile Instant Messaging Application for Older Adults Living with Chronic Knee Pain
NCT06708039
Not yet recruitingNot applicableInternational Islamic University Malaysia2024-11-18
The Effect of Intermittent Theta Burst Stimulation on Brain Characteristics, Pain Intensity, and Cognitive Functions in Older People with Chronic Musculoskeletal Pain.
NCT06709963
RecruitingNot applicableHong KongThe Hong Kong Polytechnic University2024-09-20
Intra-Articular Dexmedetomidine: A Treatment for Chronic Knee Pain
NCT06641206
RecruitingNot applicableEgyptTanta University2024-09-17
Radiofrequency Ablation for the Treatment of Post-knee Arthroplasty Chronic Pain.
NCT05920382
RecruitingNot applicableSpainConsorci Sanitari de l'Alt Penedès i Garraf2023-09-25
Peripheral Nerve Stimulation of Genicular Nerves Versus Conventional Therapy With Intra-articular Steroid Injection for Chronic Knee Pain: A Prospective, Randomized Pilot Study
NCT06004882
RecruitingNot applicableUnited StatesM.D. Anderson Cancer Center2023-08-10
Photobiomodulation in Chronic Knee Pain in Patients Who Are in PreRehabilitation for Bariatric Surgery
NCT05816798
RecruitingPhase 2, Phase 3BrazilUniversity of Nove de Julho2023-07-28
Genicular Embolization Using Doxycycline Sclerotherapy
NCT07024654
WithdrawnPhase 2Campbell Clinic2026-06
The Predictive Value of Ultrasonographic Quadriceps Muscle Parameters for Genicular Nerve Block Outcomes in Knee Osteoarthritis
NCT07781059
CompletedTurkey (Türkiye)Marmara University2025-06-01
Chronic Pain Treatment Whith Auricular Laserpuncture
NCT07010627
CompletedNot applicableBrazilUniversidade do Vale do Paraíba2025-05-20
Sequential Genicular Nerve Ablation Prior to Geniculate Artery Embolization in Knee Pain
NCT06514755
CompletedNot applicableEgyptZagazig University2024-09-29
Thermal Radiofrequency Neurolysis Versus Alcoholic Neurolysis of the Genicular Nerves for Treatment of Chronic Knee Pain in Advanced Knee Osteoarthritis
NCT07125768
CompletedNot applicableEgyptTanta University2024-07-01
The Effects of Neuroscience Based Proprioceptive Exercise Training
NCT06554483
CompletedNot applicableTurkey (Türkiye)Pamukkale University2024-06-03
Effects of iCBT and Exercise for Chronic Knee Patients
NCT06133738
Unknown statusNot applicableUniversity of Bahrain2023-12-01
Comparison Between Ultrasound-Guided Genicular Nerve Phenol Neurolysis and Intra-articular Steroid Injections
NCT06000709
Unknown statusPhase 4University of Manitoba2023-10-20
Percutaneous Peripheral Nerve Stimulation of Gluteus Nerves to Improve Hip Strength and Power
NCT06340035
Unknown statusNot applicableSpainHospital Clinic of Barcelona2023-09-01
Pharmacopuncture Therapy for Chronic Knee Pain
NCT06505681
CompletedNot applicableSouth KoreaJaseng Medical Foundation2022-12-28
Investigating RELEARN Neurofeedback as Treatment for Chronic Musculoskeletal Pain
NCT05335486
WithdrawnPhase 2, Phase 3DenmarkRedo-Neurosystems2022-10-05
Radiofrequency Ablation After Total Knee Arthroplasty
NCT05473663
Active, not recruitingNot applicableUnited StatesUniversity of Massachusetts, Worcester2022-09-01
Comparison of Conventional and Cooled Radiofrequency of the Genicular Nerves in Patients With Chronic Knee Pain
NCT05407610
Unknown statusNot applicableBelgium, NetherlandsZiekenhuis Oost-Limburg2022-07-07
Selective Nerve Ablation for Chronic Knee Pain: A Retrospective Study
NCT07835672
CompletedPolandMichał Bartoszewicz2022-06-01
Dexamethasone and Functional Outcome After TKA
NCT05137080
CompletedPhase 4DenmarkSlagelse Hospital2021-12-15
Plyometric Training in Volleyball Players With Chronic Knee Pain
NCT05251142
Unknown statusNot applicablePakistanRiphah International University2021-12-01
Brain Biomarker of Endogenous Analgesia in Patients With Chronic Knee Pain
NCT05003323
CompletedUnited StatesUniversity of Pittsburgh2021-11-18
Clinical Trial of the MiniStim PNS for Knee Pain- "FLEX" Study
NCT04580732
Unknown statusNot applicableUnited StatesMiniStim LLC2021-05-05
Assessment of the Safety and Performance of a Compression Knee Support in the Prevention of Injuries During Sports Practice
NCT04601168
TerminatedFranceDecathlon SE2021-03-25
Cooled Versus Conventional Genicular Radiofrequency Ablation for Chronic Knee Pain
NCT04275128
TerminatedUnited StatesHenry Ford Health System2020-07-11
Comparing the Effects of Upper and Lower Body Aerobic Exercise on Pain in Individuals With Chronic Knee Pain
NCT05315934
CompletedNot applicableUnited KingdomUniversity of Bath2020-02-04
Patients With Chronic Knee Pain Treated With Conventional Radiofrequency of the Genicular Nerves
NCT04234984
CompletedBelgiumZiekenhuis Oost-Limburg2020-01-26
Low-energy Laser Applications in Patients With Juvenile Idiopathic Arthritis
NCT05031104
CompletedNot applicableSaudi ArabiaCairo University2018-10-21
Radiofrequency For Chronic Knee Pain Post-Arthroplasty
NCT02931435
CompletedNot applicableUnited StatesRandall Brewer, MD, CPI2016-12
JointADventure: A Worksite Activity-Diet Intervention for Chronic Knee Pain
NCT01977872
CompletedNot applicableUnited StatesNorthwestern University2012-06

About Chronic Knee Pain

What is Chronic Knee Pain?

Osteoarthritis is the most common form of arthritis. It involves breakdown of cartilage and changes in the bone and tissues of a joint, most often in the knees, hips, hands and spine, and can cause pain, stiffness and reduced movement.

How is Chronic Knee Pain usually assessed?

Clinicians usually assess osteoarthritis through a history, physical examination of the joint and, in some cases, X-rays. Blood tests may help rule out other types of arthritis.

What kinds of treatments are studied for Chronic Knee Pain?

Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.

How can I find Chronic Knee Pain clinical trials in Canada?

This page lists 1 registry record for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.

Related conditions

Related interventions

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.