Sodium Aescinate for the Treatment of Low Back Pain (LBP) in Adults

Inclusion Criteria: 1. Meets the diagnostic criteria for chronic low back pain (cLBP) recommended by the Clinical Practice Guidelines for Chronic Low Back Pain in China (2024 Edition): the course of disease lasts at least 12 weeks, with pain occurring in the region below the lower costal margin, above the gluteal crease (horizontal gluteal fold), and between the midaxillary lines on both sides, which may be accompanied by pain in one or both lower extremities. 2. Has moderate to severe pain, with a Visual Analog Scale (VAS) score \> 4 points. 3. Aged between 18 and 65 years old. 4. Has a clear understanding of the study content, good compliance, and high willingness to cooperate. 5. Has signed a written informed consent form voluntarily. Exclusion Criteria: 1. Is in the acute pain phase or acute exacerbation of chronic pain. 2. Has low back pain caused by other reasons such as infectious diseases or tumors, including but not limited to spinal tumors, spinal tuberculosis, spinal cord infections, etc. 3. Has a history of allergy to sodium aescinate. 4. Suffers from systemic diseases or organ dysfunction. 5. Has participated in other clinical trials within 1 month before enrollment. 6. Has severe mental illness or other conditions that prevent cooperation with the study. 7. Is a pregnant or lactating woman, or a woman planning to become pregnant. 8. Has metal implants or other conditions that are not suitable for MRI examination. 9. Is considered by the researcher to have conditions that are unfavorable for completing the study course.