EXpain Trial - Exercise an a Non-pharmacological Pain-relieving Treatment in People With Multiple Sclerosis

Brief summary (from the registry)

The primary goal of this study is to test whether 12 weeks of progressive resistance exercise is an effective non-pharmacological treatment for reducing pain in people with multiple sclerosis and chronic pain. The study will be a randomized controlled trial with multiple training sites. After baseline testing, participants will be randomly assigned to either a 12-week progressive resistance exercise intervention followed by a 12-week follow-up period or to a 24-week waitlist control group that receives usual care. It is hypothesized that people with multiple sclerosis and chronic pain who receive the intervention will experience greater reductions in pain (i.e., clinically relevant reductions) compared to the waitlist control group (primary hypothesis), and that this pain reduction will be preserved after a 12-week follow-up period (secondary hypothesis).

Study details

Official title

EXpain - Is Exercise an Effective Non-pharmacological Analgesic Treatment in People With Multiple Sclerosis?

Conditions

• Multiple Sclerosis
• Chronic Pain
• Neuropathic Pain

Interventions

• Other: Progressive resistance exercise
• Other: Usual Care followed by progressive resistance exercise

Sponsor

University of Aarhus

Collaborators

Aalborg University

Start date

2026-01-15

Primary completion

2028-07-01

Sex

All

Age range

from 18 Years

Results posted

No results posted in this snapshot

Countries

Denmark

Total sites listed

1

Eligibility criteria