Magnesium Sulfate Infusion on Postoperative Pain in Lumbar Surgery

CompletedNot applicableNCT07418580

View the official record on ClinicalTrials.gov

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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.

Brief summary (from the registry)

Effective postoperative analgesia after lumbar spine surgery (e.g., laminectomy, vertebroplasty, lumbar stabilization) is associated with faster recovery and shorter hospital stay. Multimodal analgesia aims to reduce opioid consumption and related adverse effects by combining agents with complementary mechanisms of action at peripheral and central levels. Magnesium is one of the agents used in this approach. Its analgesic effects are attributed to inhibition of neuropathic pain, potentiation of opioid analgesia, and attenuation of opioid tolerance. Mechanistically, magnesium acts as a non-competitive NMDA receptor antagonist and modulates intracellular calcium influx, thereby reducing central glutamate release and limiting hyperalgesia. However, the clinical efficacy of perioperative magnesium remains controversial. Outcomes may vary depending on timing (intraoperative vs. postoperative), dosing strategies (bolus vs. infusion), and total administered dose. The optimal dosage, administration method, safety profile, and dose-response relationship of magnesium for analgesic purposes are not yet clearly established. This study aims to evaluate the effectiveness of perioperative low-dose magnesium sulfate (MgSO₄) in this context.

Study details

Official title: The Effects of Perioperative Low-dose Magnesium Sulfate Infusion on Postoperative Pain in Lumbar Surgery
Conditions: Postoperative Pain
Back Pain Lower Back Chronic
Interventions: Drug: Magnesium sulfate
Drug: normal saline
Sponsor: Sisli Hamidiye Etfal Training and Research Hospital
Start date: 2021-04-01
Primary completion: 2021-11-01
Sex: All
Age range: from 18 Years
Results posted: No results posted in this snapshot
Countries: Turkey (Türkiye)
Total sites listed: 1

Eligibility criteria

Show eligibility criteria (verbatim from the registry)

Inclusion Criteria: * aged 18 years and older, * ASA (American Society of Anesthesiologists) physical status I-II, * awaiting to undergo lumbar spinal surgery under general anesthesia. Exclusion Criteria: * the presence of cardiac conduction disorders and/or cardiac comorbidities * use of Ca channel blockers, * hepatic/renal failure and allergy to Mg.

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT07418580