Brain and Gene Expression Responses to Exercise in Chronic Back Pain

CompletedNot applicableNCT07480460

View the official record on ClinicalTrials.gov

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Brief summary (from the registry)

This study is registered retrospectively for transparency. This mechanistic randomized controlled trial examined whether a 14-week supervised physical exercise training program reduces chronic low back pain (CLBP) by modulating frontostriatal brain connectivity and immune-related gene expression. Fifty-seven adults with CLBP were randomized to exercise training or wait-list control. Participants underwent pre- and post-intervention MRI, questionnaires, and blood sampling. The study tested whether reductions in nucleus accumbens-medial prefrontal cortex connectivity and changes in inflammatory gene expression mediated exercise-induced pain relief.

Study details

Official title: Frontostriatal Connectivity and Gene Expression in Exercise-induced Relief of Back Pain
Conditions: Chronic Low Back Pain (CLBP)
Interventions: Behavioral: Supervised physical exercise training
Sponsor: McGill University
Collaborators: Canadian Institutes of Health Research (CIHR)
Start date: 2017-03-31
Primary completion: 2021-12-14
Sex: All
Age range: from 18 Years
Results posted: No results posted in this snapshot
Countries: Canada
Total sites listed: 1

Eligibility criteria

Show eligibility criteria (verbatim from the registry)

Inclusion Criteria: * Age ≥ 18 years * Chronic low back pain ≥ 3 months * Pain present at least half the days over the past 6 months * Average pain intensity ≥ 3/10 during week prior to enrollment Exclusion Criteria: * Diabetes * Neurological disorder * Psychiatric disorder * Significant cardiorespiratory disease * Under 18 years of age

Canadian sites (1)

Facility	City	Province
Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal	Montreal	Quebec

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT07480460