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Chronic Low Back Pain (CLBP): clinical trials and information

Chronic low back pain is back pain that lasts for 12 weeks or longer. In many cases no single specific cause is found. It is one of the most common reasons people see a health professional.
4
Trials with Canadian sites
2
Recruiting in Canada
71
Registry records worldwide

Chronic Low Back Pain (CLBP) clinical trials in Canada

4 trials, recruiting first
PhaseProvinces
PRT for Chronic Low Back Pain
NCT07696741
RecruitingNot applicableOntarioUniversity Health Network, Toronto2026-07-15
Neuroimmune Responses to Exercise in Chronic Back Pain
NCT07497425
RecruitingNot applicableQuebecMcGill University2025-06-01
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain
NCT07035093
Active, not recruitingPhase 3Eli Lilly and Company2025-05-29
Brain and Gene Expression Responses to Exercise in Chronic Back Pain
NCT07480460
CompletedNot applicableQuebecMcGill University2017-03-31

Chronic Low Back Pain (CLBP) clinical trials worldwide (outside Canada)

68 trials, 36 recruiting or not yet recruiting. Recruiting first.

PhaseCountries
RE-SCALE: Rehabilitation Engagement and Scaled Access With eXtended Reality and Artificial Intelligence
NCT07202975
Not yet recruitingNot applicableUniversitat Jaume I2027-01-01
Empowering Pain Psychology Access and Collaboration (EPPAC) to Improve Treatment Engagement Among Medicaid-insured Adults With Chronic Low Back Pain
NCT07843706
Not yet recruitingNot applicableUnited StatesJohns Hopkins University2026-11-02
Magnetic Resonance Elastography Of Chronic Low Back Pain Before And After Therapy
NCT07712458
Not yet recruitingNot applicableUnited StatesMayo Clinic2026-11-01
Psilocybin-Assisted Physical Therapy in Chronic Low Back Pain
NCT07306364
Not yet recruitingPhase 2United StatesYale University2026-10
SENECA - Smart Therapies for Chronic Pain
NCT07628179
Not yet recruitingNot applicableAustriaAurimod GmbH2026-09-17
Integration of Virtual Reality and Traditional Acupuncture: From Education to Clinical Practice.
NCT07816796
Not yet recruitingNot applicableChina Medical University Hospital2026-09-08
Study of Correlation Between Serum BDNF Levels and Pfirmann Grading and IL- 1β
NCT07807839
RecruitingSouth KoreaKeimyung University Dongsan Medical Center2026-09-01
Spinery Basivertebral Nerve Ablation for Vertebrogenic Chronic Low Back Pain
NCT07696507
Not yet recruitingNot applicableItalyAxon srl2026-09
Biologic Injection For Adults With Lumbar Disc Herniation
NCT07386548
RecruitingNot applicableUnited StatesWeill Medical College of Cornell University2026-08-30
Impairment Based Treatment Versus Modified Functional Restoration Program in Chronic Low Back Pain Patients
NCT07699419
Not yet recruitingNot applicableEgyptCairo University2026-07-01
Chronic Low Back Pain Comorbidities: Unravelling Impaired Glucose Metabolism
NCT07734714
Not yet recruitingNot applicableBelgiumVrije Universiteit Brussel2026-07
Focal Extracorporeal Shock Wave Therapy With Two Different Dosing Regimens for Chronic Low Back Pain
NCT07646132
Not yet recruitingNot applicableMexicoArmando Tonatiuh Avila Garcia2026-06-15
Connective Tissue Dry Needling for Low Back Pain Related to Local Posterior Superior Iliac Spine Pain
NCT07345871
Not yet recruitingNot applicableUniversity of Social Welfare and Rehabilitation Science2026-04-10
Chronic Low Back Pain and Osteopathic Manipulation Treatment
NCT07161661
RecruitingNot applicableUnited StatesEdward Hines Jr. VA Hospital2026-03-02
A Superiority Trial of Radiofrequency Ablation for Low Back Pain
NCT07222462
RecruitingNot applicableUnited StatesUniversity of Washington2026-02-04
Percussive Massage Therapy Using Heat Attachment in Chronic Low Back Pain
NCT07346651
Not yet recruitingNot applicableTurkey (Türkiye)Fenerbahce University2026-01-12
Clinical Research on the Comparative Effectiveness and Safety of JHG002 Therapy for Chronic Low Back Pain: A Multicenter Randomized Controlled Trial
NCT07304076
RecruitingNot applicableSouth KoreaJaseng Medical Foundation2025-12-17
Resilience Enhancement Following Sleep Treatment
NCT07298941
RecruitingPhase 2United StatesUniversity of Virginia2025-12-16
How Osteopathic Treatment Affects the Leg and Foot in People With Low Back Pain
NCT07193212
RecruitingNot applicableUnited StatesEdward Via Virginia College of Osteopathic Medicine2025-11-05
Exploring Multidimensional Trajectories in People With Low Back Pain
NCT07176845
RecruitingSwitzerlandBern University of Applied Sciences2025-10-16
Virtual Reality-Based Rehabilitation in Chronic Low Back Pain: Effects on Muscle Architecture, Balance, and Satisfaction (VR-LBPREHAB)
NCT07172828
Not yet recruitingNot applicableTurkey (Türkiye)Hacettepe University2025-10-13
A Prospective Evaluation of Spinal Cord Induced Muscle Stimulation (MuscleSCS) for the Treatment of Chronic Low Back Pain
NCT07215104
RecruitingNot applicableUnited StatesSaint Francis Hospital2025-10-07
Studying the Neurobiological Mechanisms of Non-specific Chronic Low Back Pain and Chronic Insomnia: a Four-group Cross-sectional Study
NCT06973837
RecruitingBelgiumVrije Universiteit Brussel2025-10-03
Comparison of the Immediate Effect of Passive vs. Passive-Active Hamstring Stretching on Flexibility in Patients With Chronic Low Back Pain
NCT06888895
RecruitingNot applicableFranceUniversity Hospital, Clermont-Ferrand2025-09-30
Predicting Pain and Disability From Voice Recordings in Low Back Pain
NCT07078019
Not yet recruitingnurmuhammet tas2025-09-28
The Effect of Attention Distraction on the Adherence to Exercise, in Chronic Low Back Pain Patients.
NCT07192809
Not yet recruitingNot applicableGreeceUniversity of Thessaly2025-09-20
Lumber Stabilization Exercise Versus Back Endurance Exercise Among Female University Students
NCT07163117
RecruitingNot applicableEgyptCairo University2025-09-09
Art Therapy for Adults With Chronic Low Back Pain
NCT07141069
RecruitingNot applicableHong KongThe Hong Kong Polytechnic University2025-08-16
Acute Effect of Isometric Excercise on Pain Sensitivity in Adults With Chronic Low Back Pain
NCT06963658
RecruitingNot applicableSaudi ArabiaTaif University2025-08-01
Brain Network Stimulation for Chronic Low Back Pain.
NCT06902233
RecruitingNot applicableNew ZealandUniversity of Otago2025-06-12
Multimodal Imaging and Biospecimen Collection for Low Back Pain (LBPB)
NCT06967363
Not yet recruitingChinaPeking University Third Hospital2025-05-15
Comparison Between Lumbar Stabilization Exercises and Lumbar Manipulation on Multifidus Muscle in Chronic Low Back Pain This Study Will Investigate and Compare the Effect of Lumbar Stabilization Exercises and Manipulation on Multifidus Muscle in Chronic Low Back Pain
NCT06796023
Not yet recruitingNot applicableCairo University2025-01-20
Cost-Effectiveness Analysis of a Virtual Reality-Assisted Hypnotherapy Program on Quality of Life in Patients with Chronic Low Back Pain: a Multicenter, Randomized, Prospective, Comparative, Open-Label, Parallel-Group Study
NCT06698354
Not yet recruitingNot applicableTurkey (Türkiye)University of Beykent2024-12-02
Traditional Medicine Use in Low Back Pain
NCT06627101
Not yet recruitingFederal University of Amapa2024-10-26
Brief Pain Exposure Therapy (BPET) For Nociplastic Pain
NCT06208514
RecruitingNot applicableUnited StatesUniversity of Michigan2024-03-04
Movement Quality and Balance Improvement in People With Chronic Low Back Pain Following Trunk Muscle Training
NCT06944730
RecruitingNot applicableHong KongThe Hong Kong Polytechnic University2022-06-01
Lumbar Extension Strengthening in Addition to Manual Therapy and Exercise for Chronic Low Back Pain
NCT07719452
Enrolling by invitationNot applicableUnited StatesBrooke Army Medical Center2026-08-03
Pain Neuroscience Education for Chronic Pain
NCT07693998
Enrolling by invitationNot applicableSpainUniversity of Valencia2026-05-05
Efficacy of Electroacupuncture Combined With Auricular Acupressure for Chronic Low Back Pain.
NCT07530042
CompletedNot applicableVietnamUniversity of Medicine and Pharmacy at Ho Chi Minh City2026-04-20
Effectiveness of ELDOA Stretching Combined With Standard Physiotherapy in Adults With Chronic Low Back Pain and Dural Hypomobility; A Randomized Controlled Trial.
NCT07730463
CompletedNot applicablePakistanIbadat International University, Islamabad2026-01-10
Validity and Reliability of Face-to-Face and Tele-Assessment of Core Stability and Functional Capacity
NCT07256873
CompletedTurkey (Türkiye)Istinye University2025-11-30
Egoscue and Core Stabilization for Chronic Low Back Pain
NCT07684118
Enrolling by invitationNot applicablePakistanUniversity of Lahore2025-11-15
Comparative Study on SNAG From Different Positions Low Back Pain Treatment
NCT07215286
CompletedNot applicableSaudi ArabiaUniversity of Hail2025-10-15
Can Virtual Reality Exercise Help Restore Both Body and Mind in Chronic Low Back Pain
NCT07207083
Enrolling by invitationNot applicableSouth Koreadongmin kang2025-09-28
Pain Resilience Therapy for Low Back Pain.
NCT06971809
CompletedNot applicableUnited StatesIntegrative Pain Science Institute2025-05-31
A Mediation Analysis Investigating Dry Needling Treatment Mechanisms in a Chronic Low Back Pain Population
NCT06940492
CompletedNot applicableUnited StatesUniversity of Florida2025-05-12
Trunk Control Training and Walking in Older Adults
NCT06782919
WithdrawnNot applicableUnited StatesBeth Israel Deaconess Medical Center2025-05
Electrical Dry Needling Versus Sham Dry Needling in Patients With Chronic Low Back Pain
NCT07148635
CompletedNot applicablePakistanUniversity of Lahore2025-04-09
Efficacy of Antibiotic Treatment for Patients With Chronic Low Back Pain and Modic Type I Changes - Randomized Placebo-controlled Trial
NCT06771492
Active, not recruitingPhase 3NetherlandsBart Koes2025-04-02
Trigger Point Electroacupuncture Treatment in Patients With Chronic Low Back Pain
NCT06868173
CompletedNot applicableVietnamUniversity of Medicine and Pharmacy at Ho Chi Minh City2025-03-15

About Chronic Low Back Pain (CLBP)

What is Chronic Low Back Pain (CLBP)?

Chronic low back pain is back pain that lasts for 12 weeks or longer. In many cases no single specific cause is found. It is one of the most common reasons people see a health professional.

How is Chronic Low Back Pain (CLBP) usually assessed?

Assessment usually involves a history and physical examination, with attention to warning signs that may need urgent investigation. Imaging is not needed in every case; clinicians decide based on symptoms and findings.

What kinds of treatments are studied for Chronic Low Back Pain (CLBP)?

Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.

How can I find Chronic Low Back Pain (CLBP) clinical trials in Canada?

This page lists 4 registry records for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.

Related conditions

Related interventions

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.