The Effect of Lipedema on Knee Osteoarthritis
RecruitingNCT07575555
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
This study will be one of the few to examine the effect of lipedema on knee osteoarthritis in a comparative manner with a control group within the same osteoarthritis context. Although the relationship between obesity and osteoarthritis has been extensively studied in the literature, the effect of specific adipose tissue pathologies, such as lipedema, on osteoarthritis has not been sufficiently investigated. This study aims to demonstrate the independent effect of lipedema on osteoarthritis, evaluate clinical and ultrasonographic parameters together, and contribute to early diagnosis and targeted rehabilitation strategies.
Study details
- Official title
- The Effect of Lipedema on Knee Osteoarthritis: A Cross-Sectional Analysis of Clinical Symptoms and Ultrasonographic Findings
- Conditions
- Lipedema
- Knee Osteoarthritis
- Knee Acute and Chronic Pain
- Knee
- Knee Arthritis Osteoarthritis
- Knee Arthropathy
- Knee Cartilage Defects
- Knee Cartilage Lesions
- Sponsor
- Izmir Democracy University
- Start date
- 2026-07-07
- Primary completion
- 2027-07-15
- Sex
- Female
- Age range
- from 30 Years to 65 Years
- Results posted
- No results posted in this snapshot
- Countries
- Turkey (Türkiye)
- Total sites listed
- 2
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: All participants (Group 1 + Group 2) * Women aged 30-65 * With a clinical and radiological diagnosis of knee osteoarthritis * Who agreed to participate in the study Group 1 (knee osteoarthritis with lipedema): * Patients who meet the Wold criteria for a clinical diagnosis of lipedema * An increase in subcutaneous fat thickness confirmed by ultrasound Group 2 (knee osteoarthritis without lipedema): * No diagnosis of lipedema * Exclusion of lymphedema and venous diseases Exclusion Criteria: * Inflammatory arthritis * History of knee surgery * Intra-articular injection within the past 6 months * Acute trauma * Systemic connective tissue disease * Severe venous insufficiency or lymphedema * History of malignancy * Use of gabapentinoids/SNRIs/SSRIs due to fibromyalgia or psychiatric illness * Severe cognitive impairment or communication problems that would prevent participation in the study * Pregnancy * Participants who were informed about the study and refused to participate
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT07575555