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Neurobiology of Pain in Burn Survivors

Not yet recruitingNot applicableNCT07824635
View the official record on ClinicalTrials.gov

Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.

This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.

Brief summary (from the registry)

Many burn survivors experience persistent, disabling pain that is strongly influenced by pain catastrophizing, a pattern of negative cognitive and emotional responses to pain involving feelings of helplessness, rumination, and magnification of symptoms. The primary purpose of this study is to evaluate whether an 6-week, remotely delivered cognitive-behavioral therapy program reduces pain interference (disruption to daily life) and pain catastrophizing more effectively than an 6-week pain education. Researchers also aim to identify the neurobiological mechanisms through which non-pharmacologic pain management works using functional Magnetic Resonance Imaging brain scans.

Study details

Official title
Neurobiology of Pain in Burn Survivors: Identification and Targeting of a Critical Treatment Mechanism
Conditions
Sponsor
Spaulding Rehabilitation Hospital
Start date
2027-01
Primary completion
2031-06
Sex
All
Age range
from 18 Years to 65 Years
Results posted
No results posted in this snapshot
Total sites listed
0

Eligibility criteria

Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Previously hospitalized for burn injury * Age 18 to 65 years * Able to provide written informed consent and fluent in English * Living in a community setting * Six (6) months or more post-burn injury * Burn-related pain rated as ≥4 (on a scale of 0-10) over the past week, co-localized with the site of the burn injury Exclusion Criteria: * Comorbid acute pain condition. * Comorbid chronic pain condition that is rated by the participant as more painful than the burn injury pain. * Living in an institution or medical facility. * Pregnant or nursing. * Any psychiatric condition precluding study participation, such as a disorder involving psychosis (e.g., schizophrenia), unmanaged bipolar disorder, or a severe personality disorder. * History of anxiety disorders or significant anxiety symptoms interfering with imaging procedures (e.g., panic). * Contraindication to MRI (e.g., implanted ferrous metal). * History of significant head injury (e.g., with substantial loss of consciousness). * Psychiatric hospitalization in the past 6 months. * Currently participating in therapeutic clinical research trials.

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT07824635