Pain Assessment Through Integrated Neurophysiology and Multidimensional Profiling
RecruitingNCT07846163
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
This observational case-control study aims to investigate the central neurophysiological mechanisms underlying non-specific chronic low back pain (CLBP) with neural mechanosensitivity, with wearable Optically Pumped Magnetometers Magnetoencephalography (OPM-MEG). The study evaluates brain activity dynamics at rest and during controlled movement-evoked pain. Additionally, it explores the relationship between cortical processing markers and multidimensional biopsychosocial profiles (including pain intensity, kinesiophobia, catastrophizing, sleep quality, and functional disability) and gait adaptaions in adults with CLBP aged 18 to 45 compared to healthy pain-free controls.
Study details
- Official title
- Exploring Pain: An OPM-MEG, Biomechanical, and Biopsychosocial Analysis in Chronic Low Back Pain
- Conditions
- Sponsor
- Aristotle University Of Thessaloniki
- Start date
- 2026-09-07
- Primary completion
- 2027-12
- Sex
- All
- Age range
- from 18 Years to 45 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- Greece
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria (Group of Chronic Low Back Pain Patients): * 18-45 years old * Non-specific low back pain * Duration of pain \> 3 months * Positive SLUMP test Inclusion Criteria (Group of Healthy Control Participants): * 18-45 years old * Healthy/ free of pain Exclusion Criteria (Common for both groups): * History of spinal injury * History of cancer * Bone metabolic diseases * Inflammatory conditions (spondyloarthritis or systemic inflammatory diseases) * Spondylolistethis * Presence of neurological deficits suggesting active nerve root compression/radiculopathy (pathological of tendon reflexes, sensitivity and muscle strength) * Diagnosed neurodegenerative/neurological disorders or epilepsy * Psychiatric disorders * High irritability, according to Severity, Irritability, Nature, Stage, and Stability- SINSS pain assessment tool. * Claustrophobia due to the measurement process inside the shielded room * Electrical/electronic implants(e.g. pacemakers), metallic surgical materials (e.g. plates, stent) and dental and orthodontic metallic materials (e.g. braces).
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT07846163