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Critical Limb Ischemia: clinical trials and information

"Critical Limb Ischemia" is the term study registrants used on ClinicalTrials.gov. Registry labels are not always standard medical terms, and close variants of the same label appear as separate entries. In this snapshot the term appears on 13 chronic pain registry records worldwide.
1
Trials with Canadian sites
0
Recruiting in Canada
13
Registry records worldwide

Critical Limb Ischemia clinical trials in Canada

1 trial, recruiting first
PhaseProvinces
Best Endovascular vs. Best Surgical Therapy in Patients With Critical Limb Ischemia
NCT02060630
CompletedNot applicableBritish Columbia, Manitoba, Nova Scotia, Ontario, Quebec, SaskatchewanCarelon Research2014-08

Critical Limb Ischemia clinical trials worldwide (outside Canada)

12 trials, 0 recruiting or not yet recruiting. Recruiting first.

PhaseCountries
Safety and Preliminary Efficacy of Allogeneic Endothelial Progenitor Cells (EPCs) in Patients With Critical Limb Ischemia
NCT06359912
Unknown statusPhase 1ChinaAllife Medical Science and Technology Co., Ltd.2024-04
Continuous Sciatic Block Nerve in the Management of Vascular Pain in Critical Ischemia of Lower Limbs Patients
NCT04278014
CompletedColombiaUniversidad de Antioquia2020-06-01
Treatment of Chronic Critical Limb Ischemia With G-CSF-mobilized Autologous Peripheral Blood Mononuclear Cells
NCT01833585
CompletedPhase 3ThailandMahidol University2013-04
Safety and Efficacy Study Using Gene Therapy for Critical Limb Ischemia
NCT01064440
CompletedPhase 2South Korea, United StatesHelixmith Co., Ltd.2010-07-09
Safety and Efficacy Study of Autologous Concentrated Bone Marrow Aspirate (cBMA) for Critical Limb Ischemia (CLI)
NCT01049919
TerminatedNot applicableUnited StatesZimmer Biomet2010-06
UT-15C SR in the Treatment of Critical Limb Ischemia
NCT00445159
Unknown statusPhase 2United StatesSouthern Arizona Vascular Institute2006-11
ALD-301 for Critical Limb Ischemia, Randomized Trial
NCT00392509
CompletedPhase 1, Phase 2United StatesAldagen2006-10
Randomized Study of Pregabalin for Pain Reduction in Patients With Rest Pain and Lower Limb Ischemia
NCT00403780
TerminatedPhase 4SwedenKarolinska Institutet2006-06
Stem Cells for Treating Critical Ischemia
NCT00488020
Unknown statusPhase 1BrazilInstituto de Molestias Cardiovasculares2006-04
ACPs in Severe PAD/CLI by Direct Intramuscular Injection
NCT00523731
CompletedPhase 1IsraelTheraVitae Ltd.2006-01
Study of Remodulin in Patients With Critical Limb Ischemia With No Planned Revascularization Procedures
NCT00060996
TerminatedPhase 3United StatesUnited Therapeutics2003-02
VEGF Gene Transfer for Critical Limb Ischemia
NCT00304837
CompletedPhase 1United StatesLosordo, Douglas, M.D.

About Critical Limb Ischemia

What is Critical Limb Ischemia?

"Critical Limb Ischemia" is the term study registrants used on ClinicalTrials.gov. Registry labels are not always standard medical terms, and close variants of the same label appear as separate entries. In this snapshot the term appears on 13 chronic pain registry records worldwide.

How is Critical Limb Ischemia usually assessed?

Assessment of chronic pain generally involves a clinician taking a detailed history, a physical examination and, where relevant, tests to look for underlying causes. Pain rating scales and questionnaires about function, sleep and mood are often used. The approach depends on the person and the condition.

What kinds of treatments are studied for Critical Limb Ischemia?

Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.

How can I find Critical Limb Ischemia clinical trials in Canada?

This page lists 1 registry record for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.

Related conditions

Related interventions

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.