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Headache: clinical trials and information

Migraine is a neurological condition with recurring headaches that are often throbbing and may come with nausea and sensitivity to light or sound. Chronic migraine usually refers to headache on 15 or more days a month for more than three months, with migraine features on at least eight of those days.
3
Trials with Canadian sites
0
Recruiting in Canada
53
Registry records worldwide

Headache clinical trials in Canada

3 trials, recruiting first
PhaseProvinces
rTMS Treatment of Persistent Headache and Post Concussion Symptoms Attributed to Mild Traumatic Injury to the Head
NCT03691272
CompletedPhase 1, Phase 2AlbertaUniversity of Calgary2017-04-15
Effects of Perioperative Pregabalin for Post-Craniotomy Pain
NCT01591980
WithdrawnPhase 4OntarioUnity Health Toronto2013-08
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
NCT01431326
CompletedManitoba, Ontario, QuebecDaniel Benjamin2011-11

Headache clinical trials worldwide (outside Canada)

50 trials, 6 recruiting or not yet recruiting. Recruiting first.

PhaseCountries
Sequential, Multiple Assignment, Double Randomized Preference, Migraine Behavioral Trial
NCT06170281
Not yet recruitingNot applicableUnited StatesMayo Clinic2026-12
Placebo Impacts Sleep and Pain Modulation in Chronic Pain
NCT06225817
RecruitingNot applicableUnited StatesUniversity of Maryland, Baltimore2025-04-21
Personalized Brain Stimulation to Treat Chronic Concussive Symptoms
NCT06073886
RecruitingPhase 2United StatesUniversity of California, Los Angeles2024-03-06
Repetitive Transcranial Magnetic Stimulation for Post-concussion Headaches
NCT06112093
RecruitingPhase 1United StatesState University of New York - Upstate Medical University2023-10-23
Responding With Evidence and Access for Childhood Headaches
NCT05889624
RecruitingNot applicableUnited StatesChildren's Hospital Medical Center, Cincinnati2023-08-22
Determining the Utility of a Behavioral Intervention in Chronic Migraine
NCT05415020
RecruitingNot applicableUnited StatesMayo Clinic2022-06-29
App-based Breathing Program for Migraine Relief
NCT07297901
Enrolling by invitationNot applicableUnited StatesArizona State University2025-12-15
Long-term Atogepant in Real-world Practice
NCT07699549
CompletedSpainFundación de Investigación Biomédica - Hospital Universitario de La Princesa2024-06-01
Impementation of the Exercise Recommendations for the Treatment of Primary Headaches: A Qualitative Approach to the Headache Units in Catalonia
NCT06127888
Unknown statusSpainFundació Universitària del Bages2024-03-20
Cross-cultural Adaptation, Reliability and Validity of the Turkish Version of the Headache Disability Questionnaire
NCT04736654
CompletedTurkey (Türkiye)Gazi University2024-01-01
Effect of Electromagnetic Therapy on Patients With Chronic Rhinosinusitis.
NCT05865613
CompletedNot applicableEgyptCairo University2023-06-15
A Wearable Nerve Stimulator for Chronic Migraine/Headache and Mood Disturbance in Adolescents
NCT05702528
Unknown statusNot applicableUnited StatesUniversity of South Carolina2022-12-08
Cross-cultural Adaptation, Reliability and Validity of the Turkish Version of the Headache Impact Questionnaire
NCT04765501
CompletedTurkey (Türkiye)Gazi University2022-11-01
The Effect of Accompanying Temporomandibular Joint Dysfunction in Patients With Chronic Migraine
NCT05381129
CompletedNot applicableTurkey (Türkiye)Istanbul University - Cerrahpasa2022-05-10
Efficacy of GONB in Patients of Migraine
NCT05679765
CompletedPhase 4PakistanPain Medicine Department2022-04-01
Effect of Low Level Laser Therapy in Patients With Chronic Rhinosinusitis.
NCT05861817
CompletedNot applicableEgyptCairo University2022-01-18
Treatment of Chronic Cluster Headache with TENS and ONS
NCT05023460
CompletedNot applicableDenmarkUniversity of Aarhus2021-08-27
Mind Body Balance for Pediatric Migraine
NCT04715685
Active, not recruitingNot applicableUnited StatesChildren's Hospital Medical Center, Cincinnati2021-03-09
miR-155 Expression in Episodic and Chronic Migraine
NCT05891808
Unknown statusItalyIRCCS National Neurological Institute "C. Mondino" Foundation2020-09-22
Safety Profile of PETALO CVS in the Treatment of Non-thrombotic Internal Jugular Vein Stenosis and Chronic Headache
NCT04352218
Unknown statusPhase 2University of Catania2020-09
Effectiveness of Acupuncture Clinical Pathway
NCT04490798
CompletedSpainHospital Son Llatzer2020-06-12
Xuefu-Zhuyu Capsule for the Treatment of "Qizhi Xueyu Zheng" (Qi Stagnation and Blood Stasis Syndrome)
NCT04218487
Unknown statusPhase 4ChinaZhong Wang2019-12-31
Evaluation of Headache and Childbirth in a Chronic Pain Population
NCT04632420
CompletedUnited StatesStanford University2019-09-13
Improving Safety of Diagnosis and Therapy in the Inpatient Setting
NCT04393909
CompletedNot applicableUnited StatesBrigham and Women's Hospital2019-07-01
Pulsed Radiofrequency in Chronic Headaches
NCT04339335
Unknown statusGreeceAttikon Hospital2019-03-01
Neurology Inpatient Clinical Education Trial
NCT03826056
CompletedNot applicableUnited StatesDartmouth-Hitchcock Medical Center2019-02-01
Mechanisms Of Change in Adolescent Pain Self-management
NCT04043962
CompletedNot applicableUnited StatesSeattle Children's Hospital2018-11-26
Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin
NCT02266329
CompletedPhase 1, Phase 2United StatesVA Office of Research and Development2016-01-04
Non-pharmacological Management of Chronic Migraine
NCT02953015
Unknown statusNot applicableItalyUniversita di Verona2016-01
Ticagrelor Therapy for RefrACTORy Migraine Study
NCT02518464
CompletedPhase 4United StatesColumbia University2015-10
PatientSpot Formerly Known as ArthritisPower
NCT03840928
Unknown statusUnited StatesGlobal Healthy Living Foundation2015-04-01
A Preliminary Investigation of the Efficacy of Aromatherapy in Reducing Discomfort in Youth With Chronic Headache
NCT02440997
CompletedNot applicableUnited StatesChildren's Mercy Hospital Kansas City2015-03-25
Acceptance and Commitment Therapy vs Medical Treatment as Usual Wait-list Control for Primary Headache Sufferers
NCT02734992
CompletedNot applicableCyprusUniversity of Cyprus2014-09
Effects of Fasting on Self Efficacy
NCT02113111
CompletedGermanyUniversität Duisburg-Essen2014-04
A Retrospective Chart Review to Evaluate Diagnosis and Treatment of Chronic Migraine and Headache
NCT01946126
CompletedUnited StatesAllergan2014-03
GET Living: Graded Exposure Treatment for Children and Adolescents With Chronic Pain
NCT01974791
CompletedNot applicableUnited StatesBoston Children's Hospital2013-10
Exercise Training With Physically Active Lifestyle to Reduce Headache and Quality of Life
NCT01664585
CompletedNot applicableFinlandUKK Institute2012-09-17
Safety and Efficacy of Botulinum Toxin Type A (BOTOX®) to Treat Chronic Migraine in Korea
NCT01976611
CompletedSouth KoreaAllergan2012-06
Problem Solving Skills Training For Parent Caregivers of Youth With Chronic Pain
NCT01496378
CompletedNot applicableUnited StatesSeattle Children's Hospital2012-05
Internet Intervention for Adolescents With Chronic Pain
NCT01316471
CompletedPhase 2United StatesSeattle Children's Hospital2011-05
Effect of Osteopathic Manipulative Treatment for Patients With Chronic Headache
NCT01332864
CompletedPhase 4United StatesWestern University of Health Sciences2011-03
Mindfulness-Based Cognitive Therapy for the Treatment of Chronic Headache Pain
NCT01213056
CompletedPhase 1, Phase 2United StatesUniversity of Alabama, Tuscaloosa2010-04
A Study of Family-based Cognitive-behavioral Therapy for Chronic Pediatric Headache and Anxiety
NCT01182051
CompletedNot applicableUnited StatesJohns Hopkins University2010-03
MedlinePlus Health Prescriptions: Developing a Pragmatic Approach for Clinic Use
NCT01050465
CompletedNot applicableUniversity of Missouri-Columbia2009-05
Medical Therapies for Chronic Post-Traumatic Headaches
NCT00862095
TerminatedPhase 4United StatesMadigan Army Medical Center2008-06
Web-based CBT for Children With Chronic Pain
NCT00853138
CompletedPhase 2Seattle Children's Hospital2007-05
Pediatric Chronic Headache Trial
NCT00389038
Unknown statusPhase 3United StatesChildren's Hospital Medical Center, Cincinnati2006-10
Evaluation of the Effectiveness of Topiramate in Preventing the Transformation From Episodic Migraine to Chronic Daily Headache.
NCT00212810
CompletedPhase 4Ortho-McNeil Neurologics, Inc.2005-09
Clinical Applications of High-Frequency Oscillations
NCT00600717
WithdrawnUnited StatesChildren's Hospital Medical Center, Cincinnati2000-11-01
Psychological Assessment and Treatment of Chronic Benign Headache
NCT00018811
CompletedNot applicableUnited StatesUS Department of Veterans Affairs1999-04

About Headache

What is Headache?

Migraine is a neurological condition with recurring headaches that are often throbbing and may come with nausea and sensitivity to light or sound. Chronic migraine usually refers to headache on 15 or more days a month for more than three months, with migraine features on at least eight of those days.

How is Headache usually assessed?

Diagnosis is usually based on the pattern of symptoms described in a history and a neurological examination. A headache diary is often used. Tests may be done to rule out other causes.

What kinds of treatments are studied for Headache?

Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.

How can I find Headache clinical trials in Canada?

This page lists 3 registry records for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.

Related conditions

Related interventions

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.