Headache: clinical trials and information
Headache clinical trials in Canada
| Phase | Provinces | ||||
|---|---|---|---|---|---|
| rTMS Treatment of Persistent Headache and Post Concussion Symptoms Attributed to Mild Traumatic Injury to the Head NCT03691272 | Completed | Phase 1, Phase 2 | Alberta | University of Calgary | 2017-04-15 |
| Effects of Perioperative Pregabalin for Post-Craniotomy Pain NCT01591980 | Withdrawn | Phase 4 | Ontario | Unity Health Toronto | 2013-08 |
| Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care NCT01431326 | Completed | Manitoba, Ontario, Quebec | Daniel Benjamin | 2011-11 |
Headache clinical trials worldwide (outside Canada)
50 trials, 6 recruiting or not yet recruiting. Recruiting first.
| Phase | Countries | ||||
|---|---|---|---|---|---|
| Sequential, Multiple Assignment, Double Randomized Preference, Migraine Behavioral Trial NCT06170281 | Not yet recruiting | Not applicable | United States | Mayo Clinic | 2026-12 |
| Placebo Impacts Sleep and Pain Modulation in Chronic Pain NCT06225817 | Recruiting | Not applicable | United States | University of Maryland, Baltimore | 2025-04-21 |
| Personalized Brain Stimulation to Treat Chronic Concussive Symptoms NCT06073886 | Recruiting | Phase 2 | United States | University of California, Los Angeles | 2024-03-06 |
| Repetitive Transcranial Magnetic Stimulation for Post-concussion Headaches NCT06112093 | Recruiting | Phase 1 | United States | State University of New York - Upstate Medical University | 2023-10-23 |
| Responding With Evidence and Access for Childhood Headaches NCT05889624 | Recruiting | Not applicable | United States | Children's Hospital Medical Center, Cincinnati | 2023-08-22 |
| Determining the Utility of a Behavioral Intervention in Chronic Migraine NCT05415020 | Recruiting | Not applicable | United States | Mayo Clinic | 2022-06-29 |
| App-based Breathing Program for Migraine Relief NCT07297901 | Enrolling by invitation | Not applicable | United States | Arizona State University | 2025-12-15 |
| Long-term Atogepant in Real-world Practice NCT07699549 | Completed | Spain | Fundación de Investigación Biomédica - Hospital Universitario de La Princesa | 2024-06-01 | |
| Impementation of the Exercise Recommendations for the Treatment of Primary Headaches: A Qualitative Approach to the Headache Units in Catalonia NCT06127888 | Unknown status | Spain | Fundació Universitària del Bages | 2024-03-20 | |
| Cross-cultural Adaptation, Reliability and Validity of the Turkish Version of the Headache Disability Questionnaire NCT04736654 | Completed | Turkey (Türkiye) | Gazi University | 2024-01-01 | |
| Effect of Electromagnetic Therapy on Patients With Chronic Rhinosinusitis. NCT05865613 | Completed | Not applicable | Egypt | Cairo University | 2023-06-15 |
| A Wearable Nerve Stimulator for Chronic Migraine/Headache and Mood Disturbance in Adolescents NCT05702528 | Unknown status | Not applicable | United States | University of South Carolina | 2022-12-08 |
| Cross-cultural Adaptation, Reliability and Validity of the Turkish Version of the Headache Impact Questionnaire NCT04765501 | Completed | Turkey (Türkiye) | Gazi University | 2022-11-01 | |
| The Effect of Accompanying Temporomandibular Joint Dysfunction in Patients With Chronic Migraine NCT05381129 | Completed | Not applicable | Turkey (Türkiye) | Istanbul University - Cerrahpasa | 2022-05-10 |
| Efficacy of GONB in Patients of Migraine NCT05679765 | Completed | Phase 4 | Pakistan | Pain Medicine Department | 2022-04-01 |
| Effect of Low Level Laser Therapy in Patients With Chronic Rhinosinusitis. NCT05861817 | Completed | Not applicable | Egypt | Cairo University | 2022-01-18 |
| Treatment of Chronic Cluster Headache with TENS and ONS NCT05023460 | Completed | Not applicable | Denmark | University of Aarhus | 2021-08-27 |
| Mind Body Balance for Pediatric Migraine NCT04715685 | Active, not recruiting | Not applicable | United States | Children's Hospital Medical Center, Cincinnati | 2021-03-09 |
| miR-155 Expression in Episodic and Chronic Migraine NCT05891808 | Unknown status | Italy | IRCCS National Neurological Institute "C. Mondino" Foundation | 2020-09-22 | |
| Safety Profile of PETALO CVS in the Treatment of Non-thrombotic Internal Jugular Vein Stenosis and Chronic Headache NCT04352218 | Unknown status | Phase 2 | University of Catania | 2020-09 | |
| Effectiveness of Acupuncture Clinical Pathway NCT04490798 | Completed | Spain | Hospital Son Llatzer | 2020-06-12 | |
| Xuefu-Zhuyu Capsule for the Treatment of "Qizhi Xueyu Zheng" (Qi Stagnation and Blood Stasis Syndrome) NCT04218487 | Unknown status | Phase 4 | China | Zhong Wang | 2019-12-31 |
| Evaluation of Headache and Childbirth in a Chronic Pain Population NCT04632420 | Completed | United States | Stanford University | 2019-09-13 | |
| Improving Safety of Diagnosis and Therapy in the Inpatient Setting NCT04393909 | Completed | Not applicable | United States | Brigham and Women's Hospital | 2019-07-01 |
| Pulsed Radiofrequency in Chronic Headaches NCT04339335 | Unknown status | Greece | Attikon Hospital | 2019-03-01 | |
| Neurology Inpatient Clinical Education Trial NCT03826056 | Completed | Not applicable | United States | Dartmouth-Hitchcock Medical Center | 2019-02-01 |
| Mechanisms Of Change in Adolescent Pain Self-management NCT04043962 | Completed | Not applicable | United States | Seattle Children's Hospital | 2018-11-26 |
| Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin NCT02266329 | Completed | Phase 1, Phase 2 | United States | VA Office of Research and Development | 2016-01-04 |
| Non-pharmacological Management of Chronic Migraine NCT02953015 | Unknown status | Not applicable | Italy | Universita di Verona | 2016-01 |
| Ticagrelor Therapy for RefrACTORy Migraine Study NCT02518464 | Completed | Phase 4 | United States | Columbia University | 2015-10 |
| PatientSpot Formerly Known as ArthritisPower NCT03840928 | Unknown status | United States | Global Healthy Living Foundation | 2015-04-01 | |
| A Preliminary Investigation of the Efficacy of Aromatherapy in Reducing Discomfort in Youth With Chronic Headache NCT02440997 | Completed | Not applicable | United States | Children's Mercy Hospital Kansas City | 2015-03-25 |
| Acceptance and Commitment Therapy vs Medical Treatment as Usual Wait-list Control for Primary Headache Sufferers NCT02734992 | Completed | Not applicable | Cyprus | University of Cyprus | 2014-09 |
| Effects of Fasting on Self Efficacy NCT02113111 | Completed | Germany | Universität Duisburg-Essen | 2014-04 | |
| A Retrospective Chart Review to Evaluate Diagnosis and Treatment of Chronic Migraine and Headache NCT01946126 | Completed | United States | Allergan | 2014-03 | |
| GET Living: Graded Exposure Treatment for Children and Adolescents With Chronic Pain NCT01974791 | Completed | Not applicable | United States | Boston Children's Hospital | 2013-10 |
| Exercise Training With Physically Active Lifestyle to Reduce Headache and Quality of Life NCT01664585 | Completed | Not applicable | Finland | UKK Institute | 2012-09-17 |
| Safety and Efficacy of Botulinum Toxin Type A (BOTOX®) to Treat Chronic Migraine in Korea NCT01976611 | Completed | South Korea | Allergan | 2012-06 | |
| Problem Solving Skills Training For Parent Caregivers of Youth With Chronic Pain NCT01496378 | Completed | Not applicable | United States | Seattle Children's Hospital | 2012-05 |
| Internet Intervention for Adolescents With Chronic Pain NCT01316471 | Completed | Phase 2 | United States | Seattle Children's Hospital | 2011-05 |
| Effect of Osteopathic Manipulative Treatment for Patients With Chronic Headache NCT01332864 | Completed | Phase 4 | United States | Western University of Health Sciences | 2011-03 |
| Mindfulness-Based Cognitive Therapy for the Treatment of Chronic Headache Pain NCT01213056 | Completed | Phase 1, Phase 2 | United States | University of Alabama, Tuscaloosa | 2010-04 |
| A Study of Family-based Cognitive-behavioral Therapy for Chronic Pediatric Headache and Anxiety NCT01182051 | Completed | Not applicable | United States | Johns Hopkins University | 2010-03 |
| MedlinePlus Health Prescriptions: Developing a Pragmatic Approach for Clinic Use NCT01050465 | Completed | Not applicable | University of Missouri-Columbia | 2009-05 | |
| Medical Therapies for Chronic Post-Traumatic Headaches NCT00862095 | Terminated | Phase 4 | United States | Madigan Army Medical Center | 2008-06 |
| Web-based CBT for Children With Chronic Pain NCT00853138 | Completed | Phase 2 | Seattle Children's Hospital | 2007-05 | |
| Pediatric Chronic Headache Trial NCT00389038 | Unknown status | Phase 3 | United States | Children's Hospital Medical Center, Cincinnati | 2006-10 |
| Evaluation of the Effectiveness of Topiramate in Preventing the Transformation From Episodic Migraine to Chronic Daily Headache. NCT00212810 | Completed | Phase 4 | Ortho-McNeil Neurologics, Inc. | 2005-09 | |
| Clinical Applications of High-Frequency Oscillations NCT00600717 | Withdrawn | United States | Children's Hospital Medical Center, Cincinnati | 2000-11-01 | |
| Psychological Assessment and Treatment of Chronic Benign Headache NCT00018811 | Completed | Not applicable | United States | US Department of Veterans Affairs | 1999-04 |
About Headache
What is Headache?
Migraine is a neurological condition with recurring headaches that are often throbbing and may come with nausea and sensitivity to light or sound. Chronic migraine usually refers to headache on 15 or more days a month for more than three months, with migraine features on at least eight of those days.
How is Headache usually assessed?
Diagnosis is usually based on the pattern of symptoms described in a history and a neurological examination. A headache diary is often used. Tests may be done to rule out other causes.
What kinds of treatments are studied for Headache?
Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.
How can I find Headache clinical trials in Canada?
This page lists 3 registry records for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.
Related conditions
Related interventions
- Drug: placebo (4)
- Drug: Amitriptyline (3)
- Drug: topiramate (2)
- Drug: pregabalin (2)
- Behavioral: Coping Skills Training (1)
- Behavioral: Control (1)
- Other: No Intervention (1)
- Biological: Botulinum toxin type A (1)
- Device: Transcutaneous electrical nerve stimulation (1)
- Other: conventional therapy (1)
- Procedure: Electroacupuncture (1)
- Device: Placebo (1)
- Behavioral: CBT (1)
- Device: Repetitive transcranial magnetic stimulation (1)
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.